Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor

• Published in: International journal of oncology Vol. 12; no. 1; p. 197
• Main Authors: Nagayasu, H, Hamada, J, Nakata, D, Shibata, T, Kobayashi, M, Hosokawa, M, Takeichi, N
• Format: Journal Article
• Language: English
• Published: Greece 01.01.1998
• Subjects: Acetylcysteine - pharmacology; Adenocarcinoma - pathology; Animals; Disease Progression; DNA Damage - drug effects; DNA Primers - chemistry; Epidermal Growth Factor - pharmacology; ErbB Receptors - genetics; ErbB Receptors - metabolism; Female; Flow Cytometry; Free Radical Scavengers - pharmacology; In Vitro Techniques; Mammary Neoplasms, Experimental - pathology; Microscopy, Confocal; Neoplasm Invasiveness; Oxidative Stress - drug effects; Peroxides - metabolism; Rats; Rats, Inbred SHR; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured - drug effects

We examined the effects of epidermal growth factor (EGF) on tumor progression of a weakly malignant rat mammary carcinoma cell line, ER-1. In vitro treatment with EGF enhanced tumorigenicity, metastatic capacity and in vitro invasive capacity of ER-1 cells. The increased malignancy of ER-1 cells was...