Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor
We examined the effects of epidermal growth factor (EGF) on tumor progression of a weakly malignant rat mammary carcinoma cell line, ER-1. In vitro treatment with EGF enhanced tumorigenicity, metastatic capacity and in vitro invasive capacity of ER-1 cells. The increased malignancy of ER-1 cells was...
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Published in | International journal of oncology Vol. 12; no. 1; p. 197 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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01.01.1998
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Abstract | We examined the effects of epidermal growth factor (EGF) on tumor progression of a weakly malignant rat mammary carcinoma cell line, ER-1. In vitro treatment with EGF enhanced tumorigenicity, metastatic capacity and in vitro invasive capacity of ER-1 cells. The increased malignancy of ER-1 cells was reversible, when the cells were pretreated with EGF for 24 h, whereas it was irreversible when pretreated with EGF for 1 month. EGF treatment elevated the intracellular peroxide level in ER-1 cells. When ER-1 cells were treated with EGF in the presence of N-acetylcysteine, a chemical antioxidant, the reversible or irreversible EGF-induced progression was inhibited. These results suggest that the reversible or irreversible tumor progression in ER-1 cells occur in accordance with the duration of exposure to EGF, and that reactive oxygen species may be involved in the progression. |
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AbstractList | We examined the effects of epidermal growth factor (EGF) on tumor progression of a weakly malignant rat mammary carcinoma cell line, ER-1. In vitro treatment with EGF enhanced tumorigenicity, metastatic capacity and in vitro invasive capacity of ER-1 cells. The increased malignancy of ER-1 cells was reversible, when the cells were pretreated with EGF for 24 h, whereas it was irreversible when pretreated with EGF for 1 month. EGF treatment elevated the intracellular peroxide level in ER-1 cells. When ER-1 cells were treated with EGF in the presence of N-acetylcysteine, a chemical antioxidant, the reversible or irreversible EGF-induced progression was inhibited. These results suggest that the reversible or irreversible tumor progression in ER-1 cells occur in accordance with the duration of exposure to EGF, and that reactive oxygen species may be involved in the progression. |
Author | Hamada, J Shibata, T Nagayasu, H Kobayashi, M Hosokawa, M Nakata, D Takeichi, N |
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SubjectTerms | Acetylcysteine - pharmacology Adenocarcinoma - pathology Animals Disease Progression DNA Damage - drug effects DNA Primers - chemistry Epidermal Growth Factor - pharmacology ErbB Receptors - genetics ErbB Receptors - metabolism Female Flow Cytometry Free Radical Scavengers - pharmacology In Vitro Techniques Mammary Neoplasms, Experimental - pathology Microscopy, Confocal Neoplasm Invasiveness Oxidative Stress - drug effects Peroxides - metabolism Rats Rats, Inbred SHR Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured - drug effects |
Title | Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor |
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