P2Y12, a New Platelet ADP Receptor, Target of Clopidogrel

• Published in: Biochemical and biophysical research communications Vol. 283; no. 2; pp. 379 - 383
• Main Authors: Savi, P., Labouret, C., Delesque, N., Guette, F., Lupker, J., Herbert, J.M.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 04.05.2001
• Subjects: ADP; clopidogrel; P2Y12; platelets; purinergic; clopidogrel; purinergic; ADP; platelets; P2Y12

The binding characteristics of 33P-2MeS-ADP, a stable analogue of ADP, were determined on CHO cells transfected with the human P2Y12 receptor, a novel purinergic receptor. These transfected CHO cells displayed a strong affinity for 33P-2MeS-ADP, the binding characteristics of which corresponded in a...