Constitutive HOXA5 Expression Inhibits Erythropoiesis and Increases Myelopoiesis From Human Hematopoietic Progenitors

• Published in: Blood Vol. 94; no. 2; pp. 519 - 528
• Main Authors: Crooks, Gay M., Fuller, John, Petersen, Denise, Izadi, Parvin, Malik, Punam, Pattengale, Paul K., Kohn, Donald B., Gasson, Judith C.
• Format: Journal Article
• Language: English
• Published: 15.07.1999

The role of the homeobox gene HOXA5 in normal human hematopoiesis was studied by constitutively expressing theHOXA5 cDNA in CD34+ and CD34+CD38− cells from bone marrow and cord blood. By using retroviral vectors that contained both HOXA5and a cell surface marker gene, pure populations of progenitors...