PGE 2 -EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease

• Published in: Neurobiology of aging Vol. 50; pp. 13 - 24
• Main Authors: Maingret, Vincent, Barthet, Gaël, Deforges, Séverine, Jiang, Nan, Mulle, Christophe, Amédée, Thierry
• Format: Journal Article
• Language: English
• Published: United States 01.02.2017
• Subjects: Aging - metabolism; Aging - physiology; Alzheimer Disease - etiology; Alzheimer Disease - therapy; Animals; Dinoprostone - physiology; Disease Models, Animal; Hippocampus - physiopathology; Long-Term Potentiation; Male; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; Neuronal Plasticity - genetics; Neuronal Plasticity - physiology; Receptors, Prostaglandin E, EP3 Subtype - physiology; Signal Transduction - physiology; Synapses - physiology; Synaptic Transmission - genetics; Synaptic Transmission - physiology; Inflammation; Alzheimer's disease; APP/PS1; Hippocampus; Synaptic plasticity; PGE

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by early cognitive deficits linked to synaptic dysfunction and loss. Considerable evidence suggests that neuroinflammation contributes to AD. Prostaglandin E (PGE ), a key neuroinflammatory molecule, modulates hip...