Thiol-Disulphide Homoeostasis in COVID-19: Evaluation of its Relationship with Complete Blood Count Parameters

Objective: In this study, we aimed to evaluate the relationship between thiol-disulfide homoeostasis and hemogram parameters in COVID-19 patients. Methods: Total thiol(TT), Native thiol(NT), dynamic disulfide status(DDS), DDS/NT, DDS/TT, NT/TT ratio and CBC parameters were analyzed in 68 patients wi...

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Published inKonuralp Tıp Dergisi Vol. 13; no. S1; pp. 460 - 467
Main Authors ŞEKEROĞLU, Mehmet Ramazan, ÇOKLUK, Erdem, YAYLACI, Selcuk, ERDEM, Ali Fuat, TUNCER, Fatıma Betül, DHEİR, Hamad, GÜÇLÜ, Ertuğrul, ÖĞÜTLÜ, Aziz, ÇEKİÇ, Deniz, AYDIN, Abdülkadir, SERİNKAN CİNEMRE, Fatma Behice
Format Journal Article
LanguageEnglish
Published 30.08.2021
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Abstract Objective: In this study, we aimed to evaluate the relationship between thiol-disulfide homoeostasis and hemogram parameters in COVID-19 patients. Methods: Total thiol(TT), Native thiol(NT), dynamic disulfide status(DDS), DDS/NT, DDS/TT, NT/TT ratio and CBC parameters were analyzed in 68 patients with positive COVID-19 and 31 healthy individuals. Results: TT, NT, DD, hemoglobin and hematocrit levels were higher in the control group than in patient groups. TT, NT, DD and lymphocyte levels of COVID-19 patients treated in medical floor were higher than those treated in intensive care unit; WBC, neutrophil and NLR were low(P Amaç: Bu çalışmada, COVID-19 hastalarında tiyol-disülfid homoeostazı ile hemogram parametreleri arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç Yöntem: Total tiyol (TT), Native tiyol (NT), dinamik disülfid durumu (DDS), DDS / NT, DDS / TT, NT / TT oranı ve CBC parametreleri COVID-19 pozitif 68 hasta ve 31 sağlıklı bireyde analiz edildi. Bulgular: Kontrol grubunda TT, NT, DD, hemoglobin ve hematokrit düzeyleri hasta gruplarına göre daha yüksekti. Serviste tedavi gören COVID-19 hastalarının TT, NT, DD ve lenfosit seviyeleri yoğun bakım ünitesinde tedavi edilenlere göre daha yüksekti; WBC, nötrofil ve NLO düşüktü (P
AbstractList Objective: In this study, we aimed to evaluate the relationship between thiol-disulfide homoeostasis and hemogram parameters in COVID-19 patients. Methods: Total thiol(TT), Native thiol(NT), dynamic disulfide status(DDS), DDS/NT, DDS/TT, NT/TT ratio and CBC parameters were analyzed in 68 patients with positive COVID-19 and 31 healthy individuals. Results: TT, NT, DD, hemoglobin and hematocrit levels were higher in the control group than in patient groups. TT, NT, DD and lymphocyte levels of COVID-19 patients treated in medical floor were higher than those treated in intensive care unit; WBC, neutrophil and NLR were low(P Amaç: Bu çalışmada, COVID-19 hastalarında tiyol-disülfid homoeostazı ile hemogram parametreleri arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç Yöntem: Total tiyol (TT), Native tiyol (NT), dinamik disülfid durumu (DDS), DDS / NT, DDS / TT, NT / TT oranı ve CBC parametreleri COVID-19 pozitif 68 hasta ve 31 sağlıklı bireyde analiz edildi. Bulgular: Kontrol grubunda TT, NT, DD, hemoglobin ve hematokrit düzeyleri hasta gruplarına göre daha yüksekti. Serviste tedavi gören COVID-19 hastalarının TT, NT, DD ve lenfosit seviyeleri yoğun bakım ünitesinde tedavi edilenlere göre daha yüksekti; WBC, nötrofil ve NLO düşüktü (P
Author ŞEKEROĞLU, Mehmet Ramazan
YAYLACI, Selcuk
DHEİR, Hamad
ÖĞÜTLÜ, Aziz
ERDEM, Ali Fuat
TUNCER, Fatıma Betül
ÇOKLUK, Erdem
SERİNKAN CİNEMRE, Fatma Behice
AYDIN, Abdülkadir
GÜÇLÜ, Ertuğrul
ÇEKİÇ, Deniz
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