Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2

• Published in: Medicinal chemistry research Vol. 33; no. 9; pp. 1568 - 1577
• Main Authors: Kanhed, Ashish M., Vora, Amisha, Thakkar, Ami, Rudramurthy, Gudepalya Renukaiah, Shandil, Radha Krishan, Harisha, Rajappa, Singh, Mayas, Narayanan, Shridhar
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2024; Springer Nature B.V
• Subjects: Antiviral activity; Antiviral agents; Benzene; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Chemical synthesis; Coronaviruses; COVID-19; Drug development; Enzymes; Imidazole; Inorganic Chemistry; Medicinal Chemistry; Original Research Article; Pharmacology/Toxicology; Public health; Severe acute respiratory syndrome coronavirus 2; Viral diseases; Ancestral SARS-CoV-2 variant; SARS-CoV-2; imidazole; inhibition; Delta variant; 3CL; Diphenyl

The prevailing COVID-19 pandemic, triggered by the novel coronavirus SARS-CoV-2, stands as the predominant global health crisis of the decade, claiming millions of lives and causing profound disruptions to society. Despite the rapid development of vaccines against COVID-19, the situation remains cha...