Anaesthetic and postanaesthetic effect of isoflurane on the multiple-unit activity of the immature rat hippocampus

We investigated anesthetic and postanaesthetic effect of isoflurane on the multi-unit activity (MUA) in the CA3 region of immature rat hippocampus. MUA amplitude did not significantly change during application of isoflurane. On the other hand MUA frequency significantly decreased during the anesthes...

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Bibliographic Details
Published inFiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Vol. 57; no. 1; pp. 17 - 20
Main Authors Isaeva, E V, Isaev, D S
Format Journal Article
LanguageEnglish
Published Ukraine 2011
Subjects
Action Potentials - drug effects
Action Potentials - physiology
Anesthesia
Anesthetics, Inhalation - administration & dosage
Anesthetics, Inhalation - pharmacology
Animals
CA3 Region, Hippocampal - drug effects
CA3 Region, Hippocampal - growth & development
CA3 Region, Hippocampal - physiology
In Vitro Techniques
Isoflurane - administration & dosage
Isoflurane - pharmacology
Pyramidal Cells - drug effects
Pyramidal Cells - physiology
Rats
Rats, Sprague-Dawley
Time Factors
Volatilization
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Summary:We investigated anesthetic and postanaesthetic effect of isoflurane on the multi-unit activity (MUA) in the CA3 region of immature rat hippocampus. MUA amplitude did not significantly change during application of isoflurane. On the other hand MUA frequency significantly decreased during the anesthesia. After isoflurane discontinuation two phases of MUA frequency recovery were observed: initial rapid increase followed by a slower recovery to the control level. Comparison of recovering period of the receptor mediated systems and spontaneous field activity from isoflurane anesthesia is discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2522-9028
2522-9036
DOI:10.15407/fz57.01.017