Natural history of intracranial artery stenosis in normal subjects received brain health check-up

• Published in: Japanese Journal of Stroke Vol. 26; no. 4; pp. 624 - 628
• Main Authors: Nagai, Atsushi, Yamaguchi, Shuhei, Bokura, Hirokazu, Iijima, Kenichi, Oguro, Hiroaki, Kobayashi, Shotai, Takahashi, Kazuo
• Format: Journal Article
• Language: Japanese
• Published: The Japan Stroke Society 2004
• Subjects: Brain health chech-up; intracranial arterial stenosis; natural history; silent brain infarction
• ISSN: 0912-0726; 1883-1923
• DOI: 10.3995/jstroke.26.624

Purpose : We started MR-angiography examination from 1992 in our brain health check-up opened at 1988 in Institute of Shimane Health Science. We studied natural history of intracranial artery stenosis in 2, 164 neurological normal subjects without any stroke history who received our brain health check-up. Methods: We analyzed the influence of intracranial artery stenotic lesion for stroke onset during follow up including risk factors such as hypertension, silent brain infarction (SBI) and silent white matter lesion (PVH3-4). Results : Intracranial artery stenosis was observed 4.7% including mild stenosis. The risk factors for arterial stenosis were aging and hypertension. Intracarnial artery stenosis significantly related to SBI and PVH3-4. Logistic analysis revealed that stenotic lesion is significant predictor for brain infarction (Odds ratio : 2.6). Severe stenosis related stroke onset. Conclusion : Intracranial artery stenosis could be a predictor for brain infarction in normal subjects. Therefore, strict control of risk factors and intervention should be needed for these subjects.