Destruction of Salivary and Lacrimal Glands by Th1-Polarized Reaction in a Model of Secondary Sjögren’s Syndrome in Lupus-Prone Female NZB × NZWF1 Mice

• Published in: Inflammation Vol. 35; no. 2; pp. 638 - 646
• Main Authors: Hayashi, Toshiharu, Shimoyama, Natsumi, Mizuno, Takuya
• Format: Journal Article
• Language: English; Japanese
• Published: Boston Springer US 01.04.2012
• Subjects: Biomedical and Life Sciences; Biomedicine; Immunology; Internal Medicine; Pathology; Pharmacology/Toxicology; Rheumatology; B/WF; acini; secondary Sjögren’s syndrome; Th1; female; lupus; mice; Th2

T helper (Th)1/Th2 balance determines the direction of some kinds of autoimmune diseases. The involvement of acini areas by CD4 + helper T(Th) cell subset in submandibular and lacrimal glands are largely unknown in secondary Sjögren’s syndrome (sSjS) with systemic lupus erythematosus (SLE). Submandi...