Destruction of Salivary and Lacrimal Glands by Th1-Polarized Reaction in a Model of Secondary Sjögren’s Syndrome in Lupus-Prone Female NZB × NZWF1 Mice
T helper (Th)1/Th2 balance determines the direction of some kinds of autoimmune diseases. The involvement of acini areas by CD4 + helper T(Th) cell subset in submandibular and lacrimal glands are largely unknown in secondary Sjögren’s syndrome (sSjS) with systemic lupus erythematosus (SLE). Submandi...
Saved in:
| Published in | Inflammation Vol. 35; no. 2; pp. 638 - 646 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Boston
Springer US
01.04.2012
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | T helper (Th)1/Th2 balance determines the direction of some kinds of autoimmune diseases. The involvement of acini areas by CD4
+
helper T(Th) cell subset in submandibular and lacrimal glands are largely unknown in secondary Sjögren’s syndrome (sSjS) with systemic lupus erythematosus (SLE). Submandibular and lacrimal glands were examined immunopathologically in lupus-prone female NZB × NZW(B/W)F
1
mice, model for human sSjS with SLE. Dacryoadenitis and sialoadenitis with renal failure developed with age. Infiltration of lymphoid cells (lymphocytes and plasma cells) expanded from the periductal areas in striated ducts to the acini, and the isolated foci in the acini were observed in those organs. The destruction of duct and acini epithelium, including the myoepithelium, was induced by interferon (IFN)-γ
+
and IgG2a
+
lymphoid cells, but not by interleukin(IL)-4
+
, IL-5
+
, IL-13
+
, and IgG1
+
lymphoid cells. Compared with IL-5 and IL-13, high values of IFN-γ were produced systemically at various ages. Also local expression of IFN-γ mRNA was higher than that of IL-4 mRNA. The result suggests that the acini destruction in submandibular and lacrimal glands may be induced by systemic and local Th1 cell dominant reactions in lupus-prone B/WF
1
mice with sSjS. |
|---|---|
| AbstractList | T helper (Th)1/Th2 balance determines the direction of some kinds of autoimmune diseases. The involvement of acini areas by CD4
+
helper T(Th) cell subset in submandibular and lacrimal glands are largely unknown in secondary Sjögren’s syndrome (sSjS) with systemic lupus erythematosus (SLE). Submandibular and lacrimal glands were examined immunopathologically in lupus-prone female NZB × NZW(B/W)F
1
mice, model for human sSjS with SLE. Dacryoadenitis and sialoadenitis with renal failure developed with age. Infiltration of lymphoid cells (lymphocytes and plasma cells) expanded from the periductal areas in striated ducts to the acini, and the isolated foci in the acini were observed in those organs. The destruction of duct and acini epithelium, including the myoepithelium, was induced by interferon (IFN)-γ
+
and IgG2a
+
lymphoid cells, but not by interleukin(IL)-4
+
, IL-5
+
, IL-13
+
, and IgG1
+
lymphoid cells. Compared with IL-5 and IL-13, high values of IFN-γ were produced systemically at various ages. Also local expression of IFN-γ mRNA was higher than that of IL-4 mRNA. The result suggests that the acini destruction in submandibular and lacrimal glands may be induced by systemic and local Th1 cell dominant reactions in lupus-prone B/WF
1
mice with sSjS. |
| Author | Shimoyama, Natsumi Hayashi, Toshiharu Mizuno, Takuya |
| Author_xml | – sequence: 1 givenname: Toshiharu surname: Hayashi fullname: Hayashi, Toshiharu email: hayasi@yamaguchi-u.ac.jp organization: Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University – sequence: 2 givenname: Natsumi surname: Shimoyama fullname: Shimoyama, Natsumi organization: Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University – sequence: 3 givenname: Takuya surname: Mizuno fullname: Mizuno, Takuya organization: Laboratories of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University |
| BookMark | eNp9kE1OwzAQRi1UJFrgAOx8AYPdNHGy5K8FqUBFi5C6iSb2tKQKNrJbpLBiywkQK27BBbgJJ8GhrFiw8cjSvG_0vQ5pGWuQkD3B9wXn8sALLuOIcSFYFsUJqzdIW8QyYt1YJi3S5lHCWZRlcot0vF9wztMsjdrk_QT90q3UsrSG2hkdQ1U-gqspGE2HoFx5DxUdVOHraVHTyZ1gI1uBK59Q02uENVkaCvTCaqx-QlBZo5uU8eLzY-7QfD2_eTqujXb2Hpvt4eph5dnIhRa0j-EG0svp0dfzy-dreC6nt31BL0qFO2RzBpXH3d-5TW76p5PjMza8GpwfHw6ZEllWM1RSgy6k6skUsSdjxWVWxNArEpAzDbJIuU4LhKQba9krsi6EGStZIHKuINomcp2rnPXe4SxX5RKabksHZZULnjee87XnPHjOG895HUjxh3xopLn6X6a7ZnzYNXN0-cKunAkF_4G-ATaCmaM |
| CitedBy_id | crossref_primary_10_3389_fimmu_2022_995895 crossref_primary_10_3390_vaccines8010083 crossref_primary_10_1016_j_cytogfr_2018_12_001 crossref_primary_10_3389_fimmu_2024_1468469 crossref_primary_10_3390_ijms23116106 crossref_primary_10_1016_j_exer_2024_109937 crossref_primary_10_1177_0961203314527365 crossref_primary_10_1155_2021_3192409 crossref_primary_10_1089_jop_2016_0166 crossref_primary_10_3390_ijms19020565 crossref_primary_10_3390_biom13050724 crossref_primary_10_1016_j_exer_2013_08_013 crossref_primary_10_1016_j_jaut_2018_06_004 |
| Cites_doi | 10.1152/ajpheart.00260.2007 10.1093/rheumatology/34.4.326 10.1084/jem.20090585 10.1016/j.neures.2007.02.010 10.1046/j.1365-2249.2002.01869.x 10.1002/art.23214 10.1093/ndt/gfm465 10.1111/j.1601-0825.2007.01376.x 10.3109/08916939808996281 10.1111/j.1365-2249.2008.03615.x 10.1097/BOR.0b013e32832f0861 10.1146/annurev.iy.07.040189.001045 10.1016/0090-1229(74)90020-8 10.1007/s00428-003-0964-2 10.3109/08916939809008035 10.1097/00005792-196505000-00001 10.2177/jsci.28.10 10.1097/00006676-199405000-00015 10.1136/ard.61.6.554 10.1002/art.10577 10.1167/iovs.03-0812 10.1002/art.1780390816 10.1177/154411130201300103 10.1046/j.1365-2249.2001.01500.x 10.1111/j.1601-0825.2006.01292.x 10.1007/s00428-008-0627-4 10.1006/jaut.1999.0289 10.1155/2010/461641 10.4049/jimmunol.152.11.5532 10.1177/154411130201300102 10.1111/j.1600-0714.2008.00730.x |
| ContentType | Journal Article |
| Copyright | Springer Science+Business Media, LLC 2011 |
| Copyright_xml | – notice: Springer Science+Business Media, LLC 2011 |
| DBID | AAYXX CITATION |
| DOI | 10.1007/s10753-011-9356-y |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1573-2576 |
| EndPage | 646 |
| ExternalDocumentID | 10_1007_s10753_011_9356_y |
| GroupedDBID | --- -53 -5E -5G -BR -EM -Y2 -~C .86 .GJ .VR 06C 06D 0R~ 0VY 1N0 1SB 2.D 203 28- 29I 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5RE 5VS 67Z 6NX 78A 7X7 88E 8AO 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AAJSJ AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACUDM ACULB ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFFNX AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBWZM BDATZ BENPR BGNMA BPHCQ BSONS BVXVI C6C CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 EBD EBLON EBS EIOEI EJD EMB EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GRRUI GXS H13 HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAK LLZTM M1P M4Y MA- N2Q NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P P9S PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S37 S3B SAP SBY SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TEORI TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK6 WK8 Y6R YLTOR Z45 Z7U Z83 Z87 Z8O Z8W Z91 ZGI ZMTXR ZOVNA ~A9 ~EX AAPKM AAYXX ABBRH ABDBE ABEEZ ABFSG ACSTC ADHKG AEZWR AFDZB AFGXO AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT |
| ID | FETCH-LOGICAL-c199y-ec7dadb7c478ee475c079b5a4b6a7fda7b80d8bea625d74b92a5d75c7bee00ca3 |
| IEDL.DBID | U2A |
| ISSN | 0360-3997 |
| IngestDate | Tue Jul 01 01:48:15 EDT 2025 Thu Apr 24 23:07:08 EDT 2025 Fri Feb 21 02:35:00 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | B/WF acini secondary Sjögren’s syndrome Th1 female lupus mice Th2 |
| Language | English Japanese |
| License | http://www.springer.com/tdm |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c199y-ec7dadb7c478ee475c079b5a4b6a7fda7b80d8bea625d74b92a5d75c7bee00ca3 |
| PageCount | 9 |
| ParticipantIDs | crossref_citationtrail_10_1007_s10753_011_9356_y crossref_primary_10_1007_s10753_011_9356_y springer_journals_10_1007_s10753_011_9356_y |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20120400 |
| PublicationDateYYYYMMDD | 2012-04-01 |
| PublicationDate_xml | – month: 4 year: 2012 text: 20120400 |
| PublicationDecade | 2010 |
| PublicationPlace | Boston |
| PublicationPlace_xml | – name: Boston |
| PublicationTitle | Inflammation |
| PublicationTitleAbbrev | Inflammation |
| PublicationYear | 2012 |
| Publisher | Springer US |
| Publisher_xml | – name: Springer US |
| References | Espinosa, Dardalhon, Brauner, Ambrosi, Higgs, Quintana, Ni Gabhann, Winqvist, Sundelin, Jefferies, Rozell, Kuchroo, Wahren-Herlenius (CR9) 2009; 206 Menon, Wu, Haas, Sahu, Yang, Zaheer (CR24) 2007; 58 Feltkamp (CR2) 1992; 40 Kapsogeorgou, Dimitriou, Abu-Helu, Moutsopoulos, Manoussakis (CR26) 2001; 124 Boumba, Skopouli, Moutsopoulos (CR15) 1995; 34 Akpek, Jabs, Gerard, Prendergast, Hudson, Lee, Whittum-Hudson (CR17) 2004; 45 Hayashi, Hasegawa, Sasaki, Mori, Adachi, Maeda (CR29) 2007; 22 Mosmann, Coffman (CR27) 1989; 7 Miyake, Inaba, Fukui, Ueda, Hosaka, Kamiyama, Ikehara (CR23) 2008; 152 CR34 Soyfoo, Steinfeld, Delporte (CR5) 2007; 13 Greenspan, Gutman, Weissman, Talal (CR21) 1974; 3 Hayashi, Hayashi, Fujii, Adachi, Hasegawa (CR19) 2008; 453 Robinson, Cornelius, Bounous, Yamamoto, Humphreys-Beher, Peck (CR8) 1998; 27 Mitsias, Tzioufas, Veiopoulou, Zintzaras, Tassios, Kogopoulou, Moutsopoulos, Thyphronitis (CR30) 2002; 128 Nguyen, Hu, Li, Stewart, Peck (CR10) 2008; 58 Ohyama, Nakamura, Matsuzaki, Shinohara, Hiroki, Fujimura, Yamada, Itoh, Nomoto (CR11) 1996; 39 Vitali, Bombardieri, Jonsson, Moutsopoulos, Alexander, Carsons, Daniels, Fox, Fox, Kassan, Pillemer, Talal, Weisman (CR6) 2002; 61 Hayashi, Adachi, Hasegawa (CR20) 2009; 38 Ogawa, Shimoyama, Kawakami (CR32) 2004; 28 Wen, Gu, Vandenhoff, Liu, Nadler (CR25) 2008; 294 Jabs, Lee, Whittum-Hudson, Prendergast (CR16) 2000; 41 Bolch, Bluchanan, Wohl, Bunim (CR1) 1965; 44 Ogawa, Ping, Zhenjun, Takada, Sugai (CR31) 2002; 46 Ihrler, Blasenbreu-Vogt, Sendelhofert, Rössle, Harrison, Löhrs (CR22) 2004; 444 Sun, Emmert-Buck, Fox (CR12) 1998; 28 Nishimori, Yamamoto, Okazaki, Morita, Onodera, Kino, Tamura, Yamamoto (CR3) 1994; 9 Kolkowski, Reth, Pelusa, Bosch, Pujol-Borrell, Coll, Jaraquemada (CR28) 1999; 13 Scofield (CR7) 2009; 21 Matsumoto, Okada, Kuroda, Iwamoto, Saito, Tokuhisa, Nishioka, Sumida (CR14) 1999; 4 Jabs, Prendergast (CR33) 1988; 29 Fox, Kang, Ando, Abrams, Pisa (CR13) 1994; 152 Cha, Peck, Humphereys-Beher (CR18) 2002; 13 Mitsias, Kapsogeorgou, Moutsopoulos (CR4) 2006; 12 RI Fox (9356_CR13) 1994; 152 Y Wen (9356_CR25) 2008; 294 DA Jabs (9356_CR33) 1988; 29 A Espinosa (9356_CR9) 2009; 206 CP Robinson (9356_CR8) 1998; 27 S Cha (9356_CR18) 2002; 13 D Boumba (9356_CR15) 1995; 34 TR Mosmann (9356_CR27) 1989; 7 T Hayashi (9356_CR29) 2007; 22 C Vitali (9356_CR6) 2002; 61 T Miyake (9356_CR23) 2008; 152 DI Mitsias (9356_CR30) 2002; 128 DA Jabs (9356_CR16) 2000; 41 I Matsumoto (9356_CR14) 1999; 4 9356_CR34 D Sun (9356_CR12) 1998; 28 TEW Feltkamp (9356_CR2) 1992; 40 EC Kolkowski (9356_CR28) 1999; 13 DI Mitsias (9356_CR4) 2006; 12 S Ihrler (9356_CR22) 2004; 444 T Hayashi (9356_CR19) 2008; 453 Y Ohyama (9356_CR11) 1996; 39 KJ Bolch (9356_CR1) 1965; 44 JS Greenspan (9356_CR21) 1974; 3 RH Scofield (9356_CR7) 2009; 21 K Menon (9356_CR24) 2007; 58 EK Kapsogeorgou (9356_CR26) 2001; 124 T Hayashi (9356_CR20) 2009; 38 EK Akpek (9356_CR17) 2004; 45 I Nishimori (9356_CR3) 1994; 9 MS Soyfoo (9356_CR5) 2007; 13 N Ogawa (9356_CR31) 2002; 46 CQ Nguyen (9356_CR10) 2008; 58 N Ogawa (9356_CR32) 2004; 28 |
| References_xml | – volume: 294 start-page: H1933 year: 2008 end-page: H1938 ident: CR25 article-title: Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages publication-title: American Journal of Physiology. Heart and Circulatory Physiology doi: 10.1152/ajpheart.00260.2007 – volume: 40 start-page: 105 year: 1992 end-page: 107 ident: CR2 article-title: Sjögren's syndrome in relation to other autoimmune diseases publication-title: The Netherlands Journal of Medicine – volume: 34 start-page: 326 year: 1995 end-page: 333 ident: CR15 article-title: Cytokine mRNA expression in the labial salivary gland tissues from patients with primary Sjogren's syndrome publication-title: British Journal of Rheumatology doi: 10.1093/rheumatology/34.4.326 – volume: 206 start-page: 1661 year: 2009 end-page: 1671 ident: CR9 article-title: Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway publication-title: The Journal of Experimental Medicine doi: 10.1084/jem.20090585 – volume: 58 start-page: 156 year: 2007 end-page: 163 ident: CR24 article-title: Diminished degradation of myelin basic protein by anti-sulfatide antibody and interferon-gamma in myelin from glia maturation factor-deficient mice publication-title: Neuroscience Research doi: 10.1016/j.neures.2007.02.010 – volume: 128 start-page: 562 year: 2002 end-page: 568 ident: CR30 article-title: The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjögren's syndrome publication-title: Clinical and Experimental Immunology doi: 10.1046/j.1365-2249.2002.01869.x – volume: 58 start-page: 734 year: 2008 end-page: 743 ident: CR10 article-title: Salivary gland tissue expression ofinterleukin-23 and interleukin-17 in Sjogren's syndrome: findings in humans and mice publication-title: Arthritis and Rheumatism doi: 10.1002/art.23214 – volume: 22 start-page: 3131 year: 2007 end-page: 3138 ident: CR29 article-title: Systemic administration of interleukin-4 expressing plasmid DNA delays the development of glomerulonephritis and prolongs survival in lupus-prone female NZB × NZWF mice publication-title: Nephrology, Dialysis, Transplantation doi: 10.1093/ndt/gfm465 – volume: 13 start-page: 366 year: 2007 end-page: 375 ident: CR5 article-title: Usefulness of mouse models to study the pathogenesis of Sjögren's syndrome publication-title: Oral Diseases doi: 10.1111/j.1601-0825.2007.01376.x – volume: 28 start-page: 125 year: 1998 end-page: 137 ident: CR12 article-title: Differential cytokine mRNA expression in human labial minor salivary glands in primary Sjögren's syndrome publication-title: Autoimmunity doi: 10.3109/08916939808996281 – volume: 152 start-page: 153 year: 2008 end-page: 162 ident: CR23 article-title: Prevention of graft-versus-host disease by intrabone marrow injection of donor T cells: involvement of bone marrow stromal cells publication-title: Clinical and Experimental Immunology doi: 10.1111/j.1365-2249.2008.03615.x – volume: 21 start-page: 448 year: 2009 end-page: 453 ident: CR7 article-title: Genetics of systemic lupus erythematosus and Sjogren's syndrome publication-title: Current Opinion in Rheumatology doi: 10.1097/BOR.0b013e32832f0861 – volume: 7 start-page: 145 year: 1989 end-page: 173 ident: CR27 article-title: TH1 and TH2 cells;different patterns of lymphokine secretion lead to different functional properties publication-title: Annual Reviews of Immunology doi: 10.1146/annurev.iy.07.040189.001045 – volume: 3 start-page: 16 year: 1974 end-page: 31 ident: CR21 article-title: Thymus-antigen- and immunoglobulin positive lymphocytes in tissue infiltrates of NZB/NZW mice publication-title: Clinical Immunology and Immunopathology doi: 10.1016/0090-1229(74)90020-8 – volume: 444 start-page: 356 year: 2004 end-page: 361 ident: CR22 article-title: Regeneration in chronic sialoadenitis:an analysis of proliferation and apoptosis based on double immunohistochemical labeling publication-title: Virchows Archiv doi: 10.1007/s00428-003-0964-2 – volume: 27 start-page: 29 year: 1998 end-page: 44 ident: CR8 article-title: Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice publication-title: Autoimmunity doi: 10.3109/08916939809008035 – volume: 44 start-page: 187 year: 1965 end-page: 231 ident: CR1 article-title: Sjögren's syndrome: clinical, pathological, and serological studies of sixty-two cases publication-title: Medicine doi: 10.1097/00005792-196505000-00001 – volume: 4 start-page: 519 year: 1999 end-page: 527 ident: CR14 article-title: Single cell analysis of T cells infiltrating labial salivary glands from patients with Sjogren's syndrome publication-title: International Journal of Molecular Medicine – volume: 38 start-page: 234 year: 2009 end-page: 240 ident: CR20 article-title: Treatment of anti-CD4 CD25 T cell monoclonal antibody exacervates the development of sialoadenitis in submandibular glands in lupus-prone female NZB × NZWF mice publication-title: Journal of Oral Pathology & Medicine – volume: 41 start-page: 826 year: 2000 end-page: 831 ident: CR16 article-title: Th1 versus Th2 immune responses in autoimmune lacrimal gland disease in MRL/Mp mice publication-title: Investigative Ophthalmology & Visual Science – volume: 28 start-page: 10 year: 2004 end-page: 20 ident: CR32 article-title: Molecular mechanisms of salivary gland destruction in patients with Sjögren's syndrome publication-title: Japanese Journal of Clinical Immunology doi: 10.2177/jsci.28.10 – volume: 9 start-page: 374 year: 1994 end-page: 381 ident: CR3 article-title: Identification of autoantibodies to a pancreatic antigen in patients with idiopathic chronic pancreatitis and Sjögren's syndrome publication-title: Pancreas doi: 10.1097/00006676-199405000-00015 – volume: 61 start-page: 554 year: 2002 end-page: 558 ident: CR6 article-title: European Study Group on classification criteria for Sjögren's syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group publication-title: Annals of the Rheummatic Diseases doi: 10.1136/ard.61.6.554 – volume: 46 start-page: 2730 year: 2002 end-page: 2741 ident: CR31 article-title: Involvement of the interferon-γ-inducible 10-kd protein (CXCL10) and monokine induced by interferon-γ (CXCL9), in the salivary gland lesions of patients with Sjögren's syndrome publication-title: Arthritis & Rrheumatism doi: 10.1002/art.10577 – volume: 45 start-page: 185 year: 2004 end-page: 190 ident: CR17 article-title: Chemokines in autoimmune lacrimal gland disease in MRL/MpJ mice publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.03-0812 – volume: 152 start-page: 5532 year: 1994 end-page: 5539 ident: CR13 article-title: Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome publication-title: Journal of Immunology – volume: 39 start-page: 1376 year: 1996 end-page: 1384 ident: CR11 article-title: Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome publication-title: Arthritis & Rrheumatism doi: 10.1002/art.1780390816 – volume: 13 start-page: 4 year: 2002 end-page: 6 ident: CR18 article-title: Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mice: an update publication-title: Critical Reviews in Oral Biology and Medicine doi: 10.1177/154411130201300103 – volume: 124 start-page: 126 year: 2001 end-page: 133 ident: CR26 article-title: Activation of epithelial and myoepithelial cells in the salivary glands of patients with Sjögren's syndrome:high expression of intercellular adhesion molecule-1(ICAM.1) in biopsy specimens and cultured cells publication-title: Clinical and Experimental Immunology doi: 10.1046/j.1365-2249.2001.01500.x – volume: 12 start-page: 523 year: 2006 end-page: 532 ident: CR4 article-title: Sjögren's syndrome: why autoimmune epitheliolitis? publication-title: Oral Diseases doi: 10.1111/j.1601-0825.2006.01292.x – ident: CR34 – volume: 453 start-page: 177 year: 2008 end-page: 188 ident: CR19 article-title: Ultrastructure of myoepithelial cells as a target cell insialoadenitis of submandibular glands of lupus-prone female NZB × NZWF mice publication-title: Virchows Archiv doi: 10.1007/s00428-008-0627-4 – volume: 29 start-page: 1437 year: 1988 end-page: 1443 ident: CR33 article-title: Murine models of Sjögren's syndrome. Immunohistologic analysis of different strains publication-title: Investigative Ophthalmology & Visual Science – volume: 13 start-page: 155 year: 1999 end-page: 162 ident: CR28 article-title: Th1 predominance and perforin expression in minor salivary glands from patients with primary Sjögren's syndrome publication-title: Journal of Autoimmunity doi: 10.1006/jaut.1999.0289 – volume: 40 start-page: 105 year: 1992 ident: 9356_CR2 publication-title: The Netherlands Journal of Medicine – volume: 41 start-page: 826 year: 2000 ident: 9356_CR16 publication-title: Investigative Ophthalmology & Visual Science – volume: 3 start-page: 16 year: 1974 ident: 9356_CR21 publication-title: Clinical Immunology and Immunopathology doi: 10.1016/0090-1229(74)90020-8 – volume: 29 start-page: 1437 year: 1988 ident: 9356_CR33 publication-title: Investigative Ophthalmology & Visual Science – volume: 12 start-page: 523 year: 2006 ident: 9356_CR4 publication-title: Oral Diseases doi: 10.1111/j.1601-0825.2006.01292.x – volume: 28 start-page: 10 year: 2004 ident: 9356_CR32 publication-title: Japanese Journal of Clinical Immunology doi: 10.2177/jsci.28.10 – ident: 9356_CR34 doi: 10.1155/2010/461641 – volume: 9 start-page: 374 year: 1994 ident: 9356_CR3 publication-title: Pancreas doi: 10.1097/00006676-199405000-00015 – volume: 34 start-page: 326 year: 1995 ident: 9356_CR15 publication-title: British Journal of Rheumatology doi: 10.1093/rheumatology/34.4.326 – volume: 444 start-page: 356 year: 2004 ident: 9356_CR22 publication-title: Virchows Archiv doi: 10.1007/s00428-003-0964-2 – volume: 13 start-page: 155 year: 1999 ident: 9356_CR28 publication-title: Journal of Autoimmunity doi: 10.1006/jaut.1999.0289 – volume: 13 start-page: 366 year: 2007 ident: 9356_CR5 publication-title: Oral Diseases doi: 10.1111/j.1601-0825.2007.01376.x – volume: 58 start-page: 734 year: 2008 ident: 9356_CR10 publication-title: Arthritis and Rheumatism doi: 10.1002/art.23214 – volume: 294 start-page: H1933 year: 2008 ident: 9356_CR25 publication-title: American Journal of Physiology. Heart and Circulatory Physiology doi: 10.1152/ajpheart.00260.2007 – volume: 124 start-page: 126 year: 2001 ident: 9356_CR26 publication-title: Clinical and Experimental Immunology doi: 10.1046/j.1365-2249.2001.01500.x – volume: 61 start-page: 554 year: 2002 ident: 9356_CR6 publication-title: Annals of the Rheummatic Diseases doi: 10.1136/ard.61.6.554 – volume: 152 start-page: 153 year: 2008 ident: 9356_CR23 publication-title: Clinical and Experimental Immunology doi: 10.1111/j.1365-2249.2008.03615.x – volume: 7 start-page: 145 year: 1989 ident: 9356_CR27 publication-title: Annual Reviews of Immunology doi: 10.1146/annurev.iy.07.040189.001045 – volume: 4 start-page: 519 year: 1999 ident: 9356_CR14 publication-title: International Journal of Molecular Medicine – volume: 152 start-page: 5532 year: 1994 ident: 9356_CR13 publication-title: Journal of Immunology doi: 10.4049/jimmunol.152.11.5532 – volume: 21 start-page: 448 year: 2009 ident: 9356_CR7 publication-title: Current Opinion in Rheumatology doi: 10.1097/BOR.0b013e32832f0861 – volume: 28 start-page: 125 year: 1998 ident: 9356_CR12 publication-title: Autoimmunity doi: 10.3109/08916939808996281 – volume: 58 start-page: 156 year: 2007 ident: 9356_CR24 publication-title: Neuroscience Research doi: 10.1016/j.neures.2007.02.010 – volume: 206 start-page: 1661 year: 2009 ident: 9356_CR9 publication-title: The Journal of Experimental Medicine doi: 10.1084/jem.20090585 – volume: 13 start-page: 4 year: 2002 ident: 9356_CR18 publication-title: Critical Reviews in Oral Biology and Medicine doi: 10.1177/154411130201300102 – volume: 38 start-page: 234 year: 2009 ident: 9356_CR20 publication-title: Journal of Oral Pathology & Medicine doi: 10.1111/j.1600-0714.2008.00730.x – volume: 46 start-page: 2730 year: 2002 ident: 9356_CR31 publication-title: Arthritis & Rrheumatism doi: 10.1002/art.10577 – volume: 27 start-page: 29 year: 1998 ident: 9356_CR8 publication-title: Autoimmunity doi: 10.3109/08916939809008035 – volume: 44 start-page: 187 year: 1965 ident: 9356_CR1 publication-title: Medicine doi: 10.1097/00005792-196505000-00001 – volume: 45 start-page: 185 year: 2004 ident: 9356_CR17 publication-title: Investigative Ophthalmology & Visual Science doi: 10.1167/iovs.03-0812 – volume: 39 start-page: 1376 year: 1996 ident: 9356_CR11 publication-title: Arthritis & Rrheumatism doi: 10.1002/art.1780390816 – volume: 22 start-page: 3131 year: 2007 ident: 9356_CR29 publication-title: Nephrology, Dialysis, Transplantation doi: 10.1093/ndt/gfm465 – volume: 453 start-page: 177 year: 2008 ident: 9356_CR19 publication-title: Virchows Archiv doi: 10.1007/s00428-008-0627-4 – volume: 128 start-page: 562 year: 2002 ident: 9356_CR30 publication-title: Clinical and Experimental Immunology doi: 10.1046/j.1365-2249.2002.01869.x |
| SSID | ssj0008983 |
| Score | 1.8996899 |
| Snippet | T helper (Th)1/Th2 balance determines the direction of some kinds of autoimmune diseases. The involvement of acini areas by CD4
+
helper T(Th) cell subset in... |
| SourceID | crossref springer |
| SourceType | Enrichment Source Index Database Publisher |
| StartPage | 638 |
| SubjectTerms | Biomedical and Life Sciences Biomedicine Immunology Internal Medicine Pathology Pharmacology/Toxicology Rheumatology |
| Title | Destruction of Salivary and Lacrimal Glands by Th1-Polarized Reaction in a Model of Secondary Sjögren’s Syndrome in Lupus-Prone Female NZB × NZWF1 Mice |
| URI | https://link.springer.com/article/10.1007/s10753-011-9356-y |
| Volume | 35 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT9tAEF4VkFAvqLSgAm00B05UKznetTd7DFECAhJFhIjHxdqXVarIIAIH98S1vwBx6r_oH-Cf8Es66wcPCZC4eC_jWcmzOw_PzDeErLPQBQ71Pk3RnFFuU7xzSjFqlPSFbGFouG9O7g_i7THfOYqOqj7uaV3tXqckC039pNkNXWvqf-lJFsU0nyFzkQ_d8RCPw_aD-m3JEnuTxahgpBR1KvMlFs-N0fNMaGFgep_IQuUZQrsU5SL54LLPZL5f5b6_kL8-RKzAXuEshZHyWZyLHFRmYU8ZDxsxga2idxd0Dgc_m3ToA9fT387Cvis7GOA0AwV-AtqkYOLjYeu5jH7d_cPYO7u_vp3CqMIx8NR7V-dXUzq8OMsc9Bzu4WBwsnl__efuBh-Dk8NeE_qobpbIuNc96GzTarwCNU0pc-qMsMpqYbhoOcdFZAIhdaS4jpVIrRK6FdiWdgpDJCu4lqHCNTJCOxcERrFlMpvh3l8JcMtYapkHFeU84k7GGl230KTojDGZ8hUS1N85MRX2uB-BMUkeUZO9aBIUTeJFk-QrZOPhlfMSeOMt4h-18JLqDk5fp159F_Ua-YhOUlhW63wjsyhp9x0dkUvdIHPtrePdLq6b3cFwv0FmOnGnURzH_zdU3k8 |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NTttAEF4VkKCXCgoIKLRz6KnVSo537c0e24g0bZMINUEgLtb-WVBFBhE4uCeufQLEibfgBXgTnqQzsUMFgkq92JfxrOTxzsznmfmWsfciDlFAv89zDGdc-hz3nDGCO6OpkS2OnaTh5F4_7ezKb_vJfk0WTbMwj-r3NOKGCTWnH3laJCkvZ9icRKBM3XuttHXvdJu6YtwUKboVrdW0gPmUioch6GH9cxJW2ovsVZ0PwqfKgEvsRShes_leXfFeZtcEDGuKVzjOYWCodnNagik8dI0jsogRfJlM7IItYXjY4DsEV49-BQ8_QjW3AEcFGKBzz0YTJYSCPWkZ_Ly9QcRd3F1cjWFQsxeQdPf85HzMd06PiwDtgGsE6B98vrv4fXuJl_7BXrsBPXQyK2y3vT1sdXh9qAJ3Da1LHpzyxlvlpGqGIFXiIqVtYqRNjcq9UbYZ-aYNBoGRV9Lq2OA9ccqGEEXOiFU2W-DaawykFyL3gqhEpUxk0KnFhC12OaZgQudynUXT95y5mnGcDr4YZX-5ksk0GZomI9Nk5Tr7cP_ISUW38S_hj1PjZfXOGz8vvfFf0u_YQmfY62bdr_3vb9hLTJPiql9nk82i1cMWpiJn9u3kI_wDAeDZFg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEB5BKlVceCNaXnvgBNrW8a692WOBuoUmUURaUXpx92VRGrlRkxzcU6_8AsSJf8Ef6D_pL2E2XheKAAlxsS_jWXsf8_DMfAPwlMUucij3aYHqjHJb4JlTilGjpE9ki2PDfXFyr59u7vA3u8lu6HM6abLdm5BkXdPgUZrK6erYFqs_Fb6hmU397z3JkpRWV2GBe2i7FiysbbzfWr8Qxh1ZI3GyFMWNlKIJbP6OyWXVdDkuOlc32Q3Yb160zjI5XJlN9Yo5-QXD8T--5CZcD6YoWav3zi244srbsNgLwfY78NX7pAFdlhwVZKh82Oi4Iqq0pKuMx6kYkY15sTDRFdn-0KYD7ykfnDhL3rq6ZIIclEQR33JtNGfiHXDruQw_nn1DZ788P_0yIcMAnOCpu7PxbEIHx0elI5nDMRzp7704P_109hkv_b13WZv0UL7dhZ1sffvlJg39HKhpS1lRZ4RVVgvDRcc5LhITCakTxXWqRGGV0J3IdrRT6JNZwbWMFd4TI7RzUWQUuwetEse-D4RbxgrLPIop5wl3MtVoK8amQOuPyYIvQdQsZW4C2LnvuTHKf8A0-4nPceJzP_F5tQTPLh4Z10gffyN-3ixtHg795M_Uy_9E_QQWB6-yvPu6v_UArqGBFteZQg-hhYvuHqERNNWPw0b_DsWgAzM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Destruction+of+Salivary+and+Lacrimal+Glands+by+Th1-Polarized+Reaction+in+a+Model+of+Secondary+Sj%C3%B6gren%E2%80%99s+Syndrome+in+Lupus-Prone+Female+NZB%E2%80%89%C3%97%E2%80%89NZWF1+Mice&rft.jtitle=Inflammation&rft.au=Hayashi%2C+Toshiharu&rft.au=Shimoyama%2C+Natsumi&rft.au=Mizuno%2C+Takuya&rft.date=2012-04-01&rft.pub=Springer+US&rft.issn=0360-3997&rft.eissn=1573-2576&rft.volume=35&rft.issue=2&rft.spage=638&rft.epage=646&rft_id=info:doi/10.1007%2Fs10753-011-9356-y&rft.externalDocID=10_1007_s10753_011_9356_y |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0360-3997&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0360-3997&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0360-3997&client=summon |