THE EFFECT OF PRESTORAGE FILTRATION ON PLATELET FUNCTION DURING STORAGE
The effect of prestorage filtration on platelet function and membrane surface glycoproteins was studied. Platelet concentrates (PC) prepared by apheresis (A-PC) or from whole blood and pooled (P-PC) were filtered with a leukocyte-removal filter, the Sepacell PL5N, and platelet functions and membrane...
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| Published in | Journal of the Japan Society of Blood Transfusion Vol. 40; no. 4; pp. 618 - 624 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Transfusion Medicine and Cell Therapy
1994
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| Online Access | Get full text |
| ISSN | 0546-1448 1883-8383 |
| DOI | 10.3925/jjtc1958.40.618 |
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| Abstract | The effect of prestorage filtration on platelet function and membrane surface glycoproteins was studied. Platelet concentrates (PC) prepared by apheresis (A-PC) or from whole blood and pooled (P-PC) were filtered with a leukocyte-removal filter, the Sepacell PL5N, and platelet functions and membrane glycoproteins were measured during 10 days of storage. Five pairs of filtered and non-filtered A-PCs or P-PCs were compared in this study. The average numbers of residual leukocytes in A-PC were 2.27±3.14×108/bag (non-filtered) and 8.60±11.0×106/bag (filtered), and those in P-PC were 1.46±0.92×107/bag (non-filtered) and 2.69±1.64×105/bag (filtered). No significant differences between the non-filtered and filtered PCs were observed during the storage in tests for the following: platelet functions such as aggregability and hypotonic shock response, levels of surface glycoproteins such as glycoprotein Ib and GMP-140 detected by flow cytometry, and the concentration of glycocalicin in plasma detected by enzyme immunoassay. These results indicate that prestorage filtration of PC does not effect platelet functions and it should be useful to further reduce the risks of side effects caused by the leukocytes contaminating PC. |
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| AbstractList | The effect of prestorage filtration on platelet function and membrane surface glycoproteins was studied. Platelet concentrates (PC) prepared by apheresis (A-PC) or from whole blood and pooled (P-PC) were filtered with a leukocyte-removal filter, the Sepacell PL5N, and platelet functions and membrane glycoproteins were measured during 10 days of storage. Five pairs of filtered and non-filtered A-PCs or P-PCs were compared in this study. The average numbers of residual leukocytes in A-PC were 2.27±3.14×108/bag (non-filtered) and 8.60±11.0×106/bag (filtered), and those in P-PC were 1.46±0.92×107/bag (non-filtered) and 2.69±1.64×105/bag (filtered). No significant differences between the non-filtered and filtered PCs were observed during the storage in tests for the following: platelet functions such as aggregability and hypotonic shock response, levels of surface glycoproteins such as glycoprotein Ib and GMP-140 detected by flow cytometry, and the concentration of glycocalicin in plasma detected by enzyme immunoassay. These results indicate that prestorage filtration of PC does not effect platelet functions and it should be useful to further reduce the risks of side effects caused by the leukocytes contaminating PC. |
| Author | Takahashi, Tsuneo A. Sekiguchi, Sadayoshi Segawa, Kimiko Ikeda, Yasuo Katayama, Masahiko Handa, Makoto |
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| References | 2) 半田誠, 平野武道, 池田康夫: 白血球除去フィルターを使用した血小板輸血によるHLA同種免疫の予防.「血小板輸血の展望」関口定美編, エフ・コピント・富士書院, pp. 41-50, 1993. 3) 関口定美, 高橋恒夫: 新しい白血球除去用フィルター. 外科診療, 33: 387-395, 1991. 7) Garcia, G. I., Fitzpatrick, J. E., Hoernig, L. A., Stewart, C. C. and Sweeney, J. D.: Effects of prestorage white cell-reduction of apheresis platelets on platelet glycoprotein Ib and von Willebrand factor. Transfusion, 32: 148-151, 1992. 15) 半田誠, 池田康夫: 膜損傷マーカー Glycocalicin. 臨床検査, 33: 1584-1589, 1989. 11) Stack, G. and Snyder, E. L.: Cytokine generation in stored platelet concentrates. Transfusion, 34: 20-25, 1994. 21) Miletic, V. D. and Popovic, D: Complement activation in stored platelet concentrates. Transfusion, 33: 150-154, 1993. 24) AABB Technical Manual 11th Edition. AABB, Bethesda, 1993. 10) Muylle, L. and Peetermans, M. E.: Effect of prestorage leukocyte removal on the cytokine levels in stored platelet concentrates. Vox Sang., 66: 14-17, 1994. 13) 片山政彦, 半田誠, 川合陽子, 池田康夫, 渡辺清明: マウスモノクローナル抗体による血中グライコカリシン測定エンザイムイムノアッセイ法の開発. 第13回日本血栓止血学会抄録集, p. 422, 1990. 19) Kilkson, H., Holme, S. and Murphy, S.: Platelet metabolism during storage of platelet concentrates at 22°C. Blood, 64: 406-414, 1984. 5) 関口定美, 中瀬俊枝: 血小板成分分離装置: COBE Spectra およびCS-3000 Plus.「プラスマフェレシスマニュアル'93」日本アフェレシス学会編, 中外医学社, pp. 30-36, 1993. 14) Katayama, M., Handa, M., Araki, Y., Hirai, S., Kato, I., Kawai, Y., Watanabe, K. and Ikeda, Y.: A monoclonal antibody-based enzyme immunoassay for human GMP-140/P-selectin. J. Immunol. Method., 153: 41-48, 1992. 12) 高橋恒夫, 細田真理, 関口定美: フローサイトメトリー法による白血球除去血液製剤中の白血球数確認法. 日輸血会誌, 36: 429-437, 1990. 23) 石川善英, 笹川滋: 濃厚血小板保存における血漿pHおよびガス分圧の影響. 日輸血会誌, 35: 415-418, 1989. 20) Kroll, M. H., Schafer, A. I.: Biochemical mechanisms of platelet activation. Blood, 74: 1181-1195, 1989. 22) Shimizu, T., Kouketsu, K., Kamiya, T., Futagawa, H. and Hirose, S.: A novel second-generation polyolefin container for storage of single-donor apheresis platelets. Vox Sang., 56: 174-180, 1989. 6) Sloand, E. M. and Klein, H. G.: Effect of white cells on platelets during storage. Transfusion, 30: 333-338, 1990. 17) Gulliksson, H., Shanwell, A., Wikman, A., Reppucci, A. J., Sallander, S. and Uden, A. M.: Storage of platelets in a new plastic container. Polyvinyl chloride plasticized with butyryl-ntrihexyl citrate. Vox Sang., 61: 165-170, 1991. 1) 池田康夫, 半田誠: 血液製剤からの白血球除去. Immunohaematology, 11: 145-152, 1989. 8) Dzik, W. H., Cusack, W. F., Sherburne, B. and Kickler, T.: The effect of prestorage white cell reduction on the function and viability of stored platelet concentrates. Transfusion, 32: 334-339, 1992. 4) 中條聖子, 千葉清司, 高橋恒夫, 関口定美: トップ & ボトムバッグシステムによる血液製剤の調製. 日輸血会誌, 38: 392-400, 1992. 9) Muylle, L., Joos, M., Wouters, E., DeBock, R. and Peetermans, M. E.: Increased tumor necrosis factor α (TNF α), interleukin 1, and interleukin 6 (IL-6) levels in the plasma of stored platelet concentrates: relationship between TNF α and IL-6 levels and febrile transfusion reactions. Transfusion, 33: 195-199, 1993. 16) 薬師寺千明, 高橋恒夫, 一戸和則, 丸山暢, 関口定美: 二重バッグシステムによる血小板長期液状保存. 日輸血会誌, 37: 822-829, 1991. 18) Holm, S., Heaton, W. A. L. and Whiteley, P.: Platelet storage leasion in second-generation containers: Correlation with in vivo behavior with storage up to 14 days. Vox Sang, 59: 12-18, 1990. |
| References_xml | – reference: 23) 石川善英, 笹川滋: 濃厚血小板保存における血漿pHおよびガス分圧の影響. 日輸血会誌, 35: 415-418, 1989. – reference: 18) Holm, S., Heaton, W. A. L. and Whiteley, P.: Platelet storage leasion in second-generation containers: Correlation with in vivo behavior with storage up to 14 days. Vox Sang, 59: 12-18, 1990. – reference: 8) Dzik, W. H., Cusack, W. F., Sherburne, B. and Kickler, T.: The effect of prestorage white cell reduction on the function and viability of stored platelet concentrates. Transfusion, 32: 334-339, 1992. – reference: 9) Muylle, L., Joos, M., Wouters, E., DeBock, R. and Peetermans, M. E.: Increased tumor necrosis factor α (TNF α), interleukin 1, and interleukin 6 (IL-6) levels in the plasma of stored platelet concentrates: relationship between TNF α and IL-6 levels and febrile transfusion reactions. Transfusion, 33: 195-199, 1993. – reference: 17) Gulliksson, H., Shanwell, A., Wikman, A., Reppucci, A. J., Sallander, S. and Uden, A. M.: Storage of platelets in a new plastic container. Polyvinyl chloride plasticized with butyryl-ntrihexyl citrate. Vox Sang., 61: 165-170, 1991. – reference: 2) 半田誠, 平野武道, 池田康夫: 白血球除去フィルターを使用した血小板輸血によるHLA同種免疫の予防.「血小板輸血の展望」関口定美編, エフ・コピント・富士書院, pp. 41-50, 1993. – reference: 20) Kroll, M. H., Schafer, A. I.: Biochemical mechanisms of platelet activation. Blood, 74: 1181-1195, 1989. – reference: 1) 池田康夫, 半田誠: 血液製剤からの白血球除去. Immunohaematology, 11: 145-152, 1989. – reference: 3) 関口定美, 高橋恒夫: 新しい白血球除去用フィルター. 外科診療, 33: 387-395, 1991. – reference: 19) Kilkson, H., Holme, S. and Murphy, S.: Platelet metabolism during storage of platelet concentrates at 22°C. Blood, 64: 406-414, 1984. – reference: 6) Sloand, E. M. and Klein, H. G.: Effect of white cells on platelets during storage. Transfusion, 30: 333-338, 1990. – reference: 11) Stack, G. and Snyder, E. L.: Cytokine generation in stored platelet concentrates. Transfusion, 34: 20-25, 1994. – reference: 13) 片山政彦, 半田誠, 川合陽子, 池田康夫, 渡辺清明: マウスモノクローナル抗体による血中グライコカリシン測定エンザイムイムノアッセイ法の開発. 第13回日本血栓止血学会抄録集, p. 422, 1990. – reference: 22) Shimizu, T., Kouketsu, K., Kamiya, T., Futagawa, H. and Hirose, S.: A novel second-generation polyolefin container for storage of single-donor apheresis platelets. Vox Sang., 56: 174-180, 1989. – reference: 21) Miletic, V. D. and Popovic, D: Complement activation in stored platelet concentrates. Transfusion, 33: 150-154, 1993. – reference: 4) 中條聖子, 千葉清司, 高橋恒夫, 関口定美: トップ & ボトムバッグシステムによる血液製剤の調製. 日輸血会誌, 38: 392-400, 1992. – reference: 16) 薬師寺千明, 高橋恒夫, 一戸和則, 丸山暢, 関口定美: 二重バッグシステムによる血小板長期液状保存. 日輸血会誌, 37: 822-829, 1991. – reference: 5) 関口定美, 中瀬俊枝: 血小板成分分離装置: COBE Spectra およびCS-3000 Plus.「プラスマフェレシスマニュアル'93」日本アフェレシス学会編, 中外医学社, pp. 30-36, 1993. – reference: 12) 高橋恒夫, 細田真理, 関口定美: フローサイトメトリー法による白血球除去血液製剤中の白血球数確認法. 日輸血会誌, 36: 429-437, 1990. – reference: 24) AABB Technical Manual 11th Edition. AABB, Bethesda, 1993. – reference: 15) 半田誠, 池田康夫: 膜損傷マーカー Glycocalicin. 臨床検査, 33: 1584-1589, 1989. – reference: 14) Katayama, M., Handa, M., Araki, Y., Hirai, S., Kato, I., Kawai, Y., Watanabe, K. and Ikeda, Y.: A monoclonal antibody-based enzyme immunoassay for human GMP-140/P-selectin. J. Immunol. Method., 153: 41-48, 1992. – reference: 7) Garcia, G. I., Fitzpatrick, J. E., Hoernig, L. A., Stewart, C. C. and Sweeney, J. D.: Effects of prestorage white cell-reduction of apheresis platelets on platelet glycoprotein Ib and von Willebrand factor. Transfusion, 32: 148-151, 1992. – reference: 10) Muylle, L. and Peetermans, M. E.: Effect of prestorage leukocyte removal on the cytokine levels in stored platelet concentrates. Vox Sang., 66: 14-17, 1994. |
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| Title | THE EFFECT OF PRESTORAGE FILTRATION ON PLATELET FUNCTION DURING STORAGE |
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