A35 MICROBIAL PROTEOLYTIC SIGNATURE IN ULCERATIVE COLITIS INDUCES AN INFLAMMATORY SIGNATURE IN MICROBIOTA-HUMANIZED MICE

• Published in: Journal of the Canadian Association of Gastroenterology Vol. 3; no. Supplement_1; pp. 42 - 43
• Main Authors: Galipeau, H J, Turpin, W, Caminero Fernandez, A, Santiago, A, Libertucci, J, Bermudez-Brito, M, Armstrong, S, Bedrani, L, Croitoru, K, Verdu, E
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 26.02.2020
• Subjects: Feces; Inflammatory bowel disease; Microbiota; Poster of Distinction

BackgroundAltered gut microbiota composition has been associated with inflammatory bowel diseases (IBD) including ulcerative colitis (UC), but causality and bacterially-driven mechanisms, are unclear. Proteases within the gastrointestinal tract play a critical role in maintaining homeostasis and are...