Metabolic signatures of human Alzheimer’s disease (AD): 1H NMR analysis of the polar metabolome of post-mortem brain tissue
Brain tissue from so-called Alzheimer’s disease (AD) mouse models has previously been examined using 1 H NMR-metabolomics, but comparable information concerning human AD is negligible. Since no animal model recapitulates all the features of human AD we undertook the first 1 H NMR-metabolomics invest...
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| Published in | Metabolomics Vol. 10; no. 4; pp. 744 - 753 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
New York
Springer US
01.08.2014
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1573-3882 1573-3890 |
| DOI | 10.1007/s11306-013-0610-1 |
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| Abstract | Brain tissue from so-called Alzheimer’s disease (AD) mouse models has previously been examined using
1
H NMR-metabolomics, but comparable information concerning human AD is negligible. Since no animal model recapitulates all the features of human AD we undertook the first
1
H NMR-metabolomics investigation of human AD brain tissue. Human post-mortem tissue from 15 AD subjects and 15 age-matched controls was prepared for analysis through a series of lyophilised, milling, extraction and randomisation steps and samples were analysed using
1
H NMR. Using partial least squares discriminant analysis, a model was built using data obtained from brain extracts. Analysis of brain extracts led to the elucidation of 24 metabolites. Significant elevations in brain alanine (15.4 %) and taurine (18.9 %) were observed in AD patients (
p
≤ 0.05). Pathway topology analysis implicated either dysregulation of
taurine and hypotaurine metabolism
or
alanine, aspartate and glutamate
metabolism
. Furthermore, screening of metabolites for AD biomarkers demonstrated that individual metabolites weakly discriminated cases of AD [receiver operating characteristic (ROC) AUC <0.67;
p
< 0.05]. However, paired metabolites ratios (e.g. alanine/carnitine) were more powerful discriminating tools (ROC AUC = 0.76;
p
< 0.01). This study further demonstrates the potential of metabolomics for elucidating the underlying biochemistry and to help identify AD in patients attending the memory clinic. |
|---|---|
| AbstractList | Brain tissue from so-called Alzheimer’s disease (AD) mouse models has previously been examined using
1
H NMR-metabolomics, but comparable information concerning human AD is negligible. Since no animal model recapitulates all the features of human AD we undertook the first
1
H NMR-metabolomics investigation of human AD brain tissue. Human post-mortem tissue from 15 AD subjects and 15 age-matched controls was prepared for analysis through a series of lyophilised, milling, extraction and randomisation steps and samples were analysed using
1
H NMR. Using partial least squares discriminant analysis, a model was built using data obtained from brain extracts. Analysis of brain extracts led to the elucidation of 24 metabolites. Significant elevations in brain alanine (15.4 %) and taurine (18.9 %) were observed in AD patients (
p
≤ 0.05). Pathway topology analysis implicated either dysregulation of
taurine and hypotaurine metabolism
or
alanine, aspartate and glutamate
metabolism
. Furthermore, screening of metabolites for AD biomarkers demonstrated that individual metabolites weakly discriminated cases of AD [receiver operating characteristic (ROC) AUC <0.67;
p
< 0.05]. However, paired metabolites ratios (e.g. alanine/carnitine) were more powerful discriminating tools (ROC AUC = 0.76;
p
< 0.01). This study further demonstrates the potential of metabolomics for elucidating the underlying biochemistry and to help identify AD in patients attending the memory clinic. |
| Author | Holscher, Christian Green, Brian D. Graham, Stewart F. |
| Author_xml | – sequence: 1 givenname: Stewart F. surname: Graham fullname: Graham, Stewart F. email: stewart.graham@qub.ac.uk organization: Institute for Global Food Security, Queen’s University Belfast – sequence: 2 givenname: Christian surname: Holscher fullname: Holscher, Christian organization: Division of Biomedical and Life Sciences, Lancaster University – sequence: 3 givenname: Brian D. surname: Green fullname: Green, Brian D. organization: Institute for Global Food Security, Queen’s University Belfast |
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| Cites_doi | 10.1016/0301-0082(89)90019-1 10.1093/nar/gks1065 10.1146/annurev.physiol.59.1.437 10.1016/j.neuint.2010.04.001 10.1073/pnas.0505513102 10.1007/s11306-012-0482-9 10.1007/s11306-013-0516-y 10.1016/j.brainres.2005.01.058 10.1038/nbt0208-162 10.1016/j.tibs.2008.06.006 10.1023/B:NERE.0000010448.17740.6e 10.1007/s00726-011-1047-3 10.1016/j.nbd.2004.09.005 10.1139/Y08-110 10.3390/brainsci3020877 10.1093/nar/gkp356 10.1016/j.toxlet.2004.03.002 10.1016/j.brainres.2004.02.079 10.1093/brain/awq310 10.1007/s00726-011-0885-3 10.1021/ac303163f 10.1007/s11064-011-0438-x 10.4172/2153-0769.S1.022 10.1021/pr300666p 10.1093/nar/gks374 10.1371/journal.pone.0032737 |
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| Keywords | Human Clinical Brain Metabolomics NMR Alzheimer’s disease |
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| Snippet | Brain tissue from so-called Alzheimer’s disease (AD) mouse models has previously been examined using
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H NMR-metabolomics, but comparable information... |
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| SubjectTerms | Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Developmental Biology Life Sciences Molecular Medicine Original Article |
| Title | Metabolic signatures of human Alzheimer’s disease (AD): 1H NMR analysis of the polar metabolome of post-mortem brain tissue |
| URI | https://link.springer.com/article/10.1007/s11306-013-0610-1 |
| Volume | 10 |
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