Artificial Modified Nucleotides for the Electrochemical Detection of Nucleic Acid Amplification Products

• Published in: Journal of analytical chemistry (New York, N.Y.) Vol. 79; no. 7; pp. 831 - 847
• Main Authors: Suprun, E. V., Khmeleva, S. A., Ptitsyn, K. G., Kurbatov, L. K., Radko, S. P.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.07.2024; Springer Nature B.V
• Subjects: Amplification; Analytical Chemistry; Analyzers; Chemical reactions; Chemistry; Chemistry and Materials Science; Deoxyribonucleic acid; DNA; Electroactivity; Electrochemical analysis; Gene sequencing; Nucleotides; Oxidation; Reviews; Solid electrodes; Substrates; voltammetry; nucleic acid; fluorimetry; modified nucleotide; polymerase chain reaction; isothermal amplification

The review describes the fundamental electrochemical properties of nucleic acids manifested on solid electrodes, with an emphasis on the spatial structure of macromolecules. The formation of the double helix impedes the contact of the electroactive groups of the nitrogenous bases with the electrode...