Addressing chemoresistance with a lipid gemcitabine nanotherapeutic strategy for effective treatment of pancreatic cancer

• Published in: Nano research Vol. 17; no. 9; pp. 8377 - 8388
• Main Authors: Hong, Jiawei, Xian, Shiyun, Zheng, Shusen, Wang, Hangxiang, Jiang, Donghai
• Format: Journal Article
• Language: English
• Published: Beijing Tsinghua University Press 01.09.2024; Springer Nature B.V
• Subjects: Atomic/Molecular Structure and Spectra; Bioaccumulation; Biomedicine; Biotechnology; Cancer; Chemistry and Materials Science; Chemoresistance; Clathrin; Condensed Matter Physics; Cytotoxicity; Drug resistance; Effectiveness; Endocytosis; Gemcitabine; Human performance; In vivo methods and tests; Lipids; Materials Science; Nanoparticles; Nanotechnology; Nucleoside transporter; Pancreatic cancer; Research Article; Tumor cell lines; pancreatic cancer; gemcitabine resistance; human equilibrative nucleoside transporter 1; gemcitabine nanoparticle

Resistance to gemcitabine in pancreatic cancer poses a significant clinical challenge. Further investigation is warranted to assess whether nano-formulation strategy can be employed to enhance the sensitivity of resistant strains to gemcitabine therapy. In this study, using gemcitabine-resistant pan...