The first example of the use of 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl in the Mannich reaction to obtain radical-labeled bispidines

• Published in: Russian chemical bulletin Vol. 73; no. 5; pp. 1460 - 1464
• Main Authors: Medved’ko, A. V., Ermakov, M. O., Vatsadze, S. Z.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2024; Springer Nature B.V
• Subjects: Brief Communications; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Crystal structure; Free radicals; Inorganic Chemistry; Ketones; Mass spectrometry; Molecular structure; Organic Chemistry; Reagents; 2,2,6,6-tetramethylpiperidine-1-oxyl; the Mannich reaction; ESR spectroscopy; free radicals; bispidine; X-ray diffraction analysis

Bispidine containing a paramagnetic group was obtained for the first time by the Mannich reaction using the 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO) free radical as a reagent. The structure of the target compound, tert -butyl 9-oxo-7-(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl)-3,7...