The Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAFV600E Mutation

Objective: To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation. Methods: A study was conducted on 30 radioiodine refractory papillary thyroid carcinoma patients and 30 radioiodine-avid papillary thy...

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Published inOncoTargets and therapy Vol. 14; pp. 3959 - 3969
Main Authors Anekpuritanang, Tauangtham, Uataya, Maythad, Claimon, Apichaya, Laokulrath, Natthawadee, Pongsapich, Warut, Pithuksurachai, Paveena
Format Journal Article
LanguageEnglish
Published Macclesfield Taylor & Francis Ltd 29.06.2021
Dove
Subjects
Antibodies
Brain cancer
Cancer therapies
Graves disease
Hospitals
Immunohistochemistry
Kinases
Metastasis
Mutation
Original Research
Otolaryngology
Papillary thyroid carcinoma
Paraffin
Pathology
Patients
Proteins
Sodium
Sodium iodide symporter
Thyroid
Thyroid cancer
Thailand
United States > US
Bangkok Thailand
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Abstract Objective: To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation. Methods: A study was conducted on 30 radioiodine refractory papillary thyroid carcinoma patients and 30 radioiodine-avid papillary thyroid carcinoma patients. The expressions of sodium/iodide symporter and BRAFV600E mutated protein were determined by immunohistochemistry using formalin-fixed, paraffin-embedded tissue. Results: The mutated BRAFV600E protein was identified in 26 radioiodine refractory papillary thyroid carcinoma subjects (86.7%) and 22 radioiodine-avid papillary thyroid carcinoma subjects (73.3%), with no significant difference between the 2 groups (P = 0.3). Sodium/iodide symporter expression was detected in 4 of 30 cases (13.3%) from the radioiodine-avid papillary thyroid carcinoma group but was negative for all radioiodine refractory cases. There was no association between sodium/iodide symporter expression and radioiodine refractory papillary thyroid carcinoma (P = 0.11). Cases with positive NIS expression were likely negative for BRAFV600E mutation (3/4; P = 0.02). Conclusion: Papillary thyroid carcinomas with BRAFV600E mutation were more likely to be negative for NIS expression. BRAFV600E mutation and NIS expressions cannot be used to predict radioiodine sensitivity.
AbstractList Objective: To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation. Methods: A study was conducted on 30 radioiodine refractory papillary thyroid carcinoma patients and 30 radioiodine-avid papillary thyroid carcinoma patients. The expressions of sodium/iodide symporter and BRAFV600E mutated protein were determined by immunohistochemistry using formalin-fixed, paraffin-embedded tissue. Results: The mutated BRAFV600E protein was identified in 26 radioiodine refractory papillary thyroid carcinoma subjects (86.7%) and 22 radioiodine-avid papillary thyroid carcinoma subjects (73.3%), with no significant difference between the 2 groups (P = 0.3). Sodium/iodide symporter expression was detected in 4 of 30 cases (13.3%) from the radioiodine-avid papillary thyroid carcinoma group but was negative for all radioiodine refractory cases. There was no association between sodium/iodide symporter expression and radioiodine refractory papillary thyroid carcinoma (P = 0.11). Cases with positive NIS expression were likely negative for BRAFV600E mutation (3/4; P = 0.02). Conclusion: Papillary thyroid carcinomas with BRAFV600E mutation were more likely to be negative for NIS expression. BRAFV600E mutation and NIS expressions cannot be used to predict radioiodine sensitivity.
Author Pongsapich, Warut
Anekpuritanang, Tauangtham
Claimon, Apichaya
Laokulrath, Natthawadee
Uataya, Maythad
Pithuksurachai, Paveena
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CitedBy_id crossref_primary_10_1007_s12149_022_01794_w
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crossref_primary_10_3390_cancers14153800
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Snippet Objective: To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E...
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SubjectTerms Antibodies
Brain cancer
Cancer therapies
Graves disease
Hospitals
Immunohistochemistry
Kinases
Metastasis
Mutation
Original Research
Otolaryngology
Papillary thyroid carcinoma
Paraffin
Pathology
Patients
Proteins
Sodium
Sodium iodide symporter
Thyroid
Thyroid cancer
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Title The Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAFV600E Mutation
URI https://www.proquest.com/docview/2552289738
https://pubmed.ncbi.nlm.nih.gov/PMC8254588
Volume 14
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