Retrospective study of the efficacy of methylprednisolone vs. triamcinolone in lumbar epidural steroid injections for the treatment of low back pain due to degenerative disc disease

• Published in: ANESTHESIOLOGY AND PERIOPERATIVE SCIENCE Vol. 2; no. 3; pp. 1 - 10
• Main Authors: Higgins, Zachary R., Garg, Shuchita, Burroughs, Timothy, Qualls, Katherine A., Zhang, Jun-Ming, Strong, Judith A.
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 06.09.2024; Springer
• Subjects: Anesthesiology; Critical Care Medicine; Epidural steroid; Intensive; Low back pain; Medicine; Medicine & Public Health; Mineralocorticoid receptor; Neurosciences; Original Research; Pharmacology/Toxicology; Smoking; Surgery; Epidural steroid; Mineralocorticoid receptor; Low back pain; Smoking

Objective A common low back pain treatment is epidural injection of corticosteroids. The nominal target of anti-inflammatory corticosteroid drugs is the glucocorticoid receptor (GR). In vitro studies show many clinically used steroids also activate the mineralocorticoid receptor (MR) with substantia...