Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties

• Published in: Pharmaceutisch weekblad. Scientific edition Vol. 8; no. 2; p. 109
• Main Authors: Bouma, J, Beijnen, J H, Bult, A, Underberg, W J
• Format: Journal Article
• Language: English
• Published: Netherlands 25.04.1986
• Subjects: Adsorption; Antibiotics, Antineoplastic - analysis; Chemical Phenomena; Chemistry; Chemistry, Physical; Chromatography, High Pressure Liquid; Drug Stability; Metals - analysis; Naphthacenes - analysis; Solubility; Spectrophotometry

A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furt...