Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties

A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furt...

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Bibliographic Details
Published inPharmaceutisch weekblad. Scientific edition Vol. 8; no. 2; p. 109
Main Authors Bouma, J, Beijnen, J H, Bult, A, Underberg, W J
Format Journal Article
LanguageEnglish
Published Netherlands 25.04.1986
Subjects
Adsorption
Antibiotics, Antineoplastic - analysis
Chemical Phenomena
Chemistry
Chemistry, Physical
Chromatography, High Pressure Liquid
Drug Stability
Metals - analysis
Naphthacenes - analysis
Solubility
Spectrophotometry
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Summary:A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furthermore, the stability of anthracyclines in solutions, in pharmaceutical preparations and in biological media is discussed.
ISSN:0167-6555
DOI:10.1007/BF02086146