Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties

A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furt...

Full description

Saved in:
Bibliographic Details
Published inPharmaceutisch weekblad. Scientific edition Vol. 8; no. 2; p. 109
Main Authors Bouma, J, Beijnen, J H, Bult, A, Underberg, W J
Format Journal Article
LanguageEnglish
Published Netherlands 25.04.1986
Subjects
Adsorption
Antibiotics, Antineoplastic - analysis
Chemical Phenomena
Chemistry
Chemistry, Physical
Chromatography, High Pressure Liquid
Drug Stability
Metals - analysis
Naphthacenes - analysis
Solubility
Spectrophotometry
Online AccessGet more information

Cover

Abstract A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furthermore, the stability of anthracyclines in solutions, in pharmaceutical preparations and in biological media is discussed.
AbstractList A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furthermore, the stability of anthracyclines in solutions, in pharmaceutical preparations and in biological media is discussed.
Author Beijnen, J H
Bult, A
Bouma, J
Underberg, W J
Author_xml – sequence: 1
  givenname: J
  surname: Bouma
  fullname: Bouma, J
– sequence: 2
  givenname: J H
  surname: Beijnen
  fullname: Beijnen, J H
– sequence: 3
  givenname: A
  surname: Bult
  fullname: Bult, A
– sequence: 4
  givenname: W J
  surname: Underberg
  fullname: Underberg, W J
BackLink https://www.ncbi.nlm.nih.gov/pubmed/3520474$$D View this record in MEDLINE/PubMed
BookMark eNotT81KAzEYzKFSa-3Fu5AHcOuX3U3iHmuxKhS86Ll8ySZuZP9Issq-vRE7DMwwDANzRRb90BtCbhhsGYC8fzxADg-ClWJBVsCEzATn_JJsQviCBA55CpZkWfAcSlmuCO762HjUs25dbyj20cWpGyZP8dP0MWzpjnrz7cwPHSwdmzk4PejGdE5je5f62M7xzydb0xBRudbFmY5-GI2PzoRrcmGxDWZz1jX5ODy971-y49vz6353zDSrZMyUkFInGmRYaGWl5KVAbpXSsoAUK7TSaiNQMBDpZSFqgEryukRWyypfk9v_3XFSnalPo3cd-vl0vpr_AtojV6g
CitedBy_id crossref_primary_10_1016_j_xphs_2021_08_003
crossref_primary_10_1021_acs_inorgchem_4c01338
crossref_primary_10_1016_0304_3835_90_90023_Q
crossref_primary_10_1016_j_jchromb_2010_05_031
crossref_primary_10_1021_bi401687v
crossref_primary_10_1016_0584_8539_91_80147_B
crossref_primary_10_1007_s11094_011_0661_4
crossref_primary_10_1016_j_ijpharm_2012_10_008
crossref_primary_10_1088_0957_4484_27_38_385104
crossref_primary_10_1016_j_jchromb_2017_04_038
crossref_primary_10_1016_j_ejpb_2018_11_001
crossref_primary_10_1016_S0021_9673_01_94279_7
crossref_primary_10_1039_d0pp00132e
crossref_primary_10_1016_0165_9936_93_80006_6
crossref_primary_10_1016_0731_7085_88_80079_7
crossref_primary_10_3390_pharmaceutics15020326
crossref_primary_10_1016_S0005_2736_98_00166_7
crossref_primary_10_1080_1061186X_2016_1186169
crossref_primary_10_3390_w14050821
crossref_primary_10_1016_0731_7085_91_80036_9
crossref_primary_10_1016_S0005_2736_98_00168_0
crossref_primary_10_1002_biot_201000212
crossref_primary_10_1021_ja311873t
crossref_primary_10_1016_S0969_8043_97_00302_3
crossref_primary_10_1002_pbc_22266
crossref_primary_10_1002_jps_2600771002
crossref_primary_10_1007_BF02921477
crossref_primary_10_1016_S1773_2247_13_50022_0
crossref_primary_10_1016_j_ejps_2003_10_013
crossref_primary_10_1158_1078_0432_CCR_1131_03
crossref_primary_10_1007_s00280_004_0900_4
crossref_primary_10_1016_j_molliq_2023_121512
crossref_primary_10_1016_j_drudis_2016_11_005
crossref_primary_10_1016_0378_5173_87_90187_6
crossref_primary_10_1016_j_jpba_2010_10_024
crossref_primary_10_1155_2012_831263
crossref_primary_10_1158_1535_7163_MCT_10_0609
crossref_primary_10_1016_j_talanta_2011_08_034
crossref_primary_10_3390_molecules22071106
crossref_primary_10_1016_j_jconrel_2012_02_018
crossref_primary_10_1007_s00270_011_0168_0
crossref_primary_10_1002_macp_1991_021921209
crossref_primary_10_1016_j_jchromb_2011_07_010
crossref_primary_10_1016_j_bbamem_2006_05_028
crossref_primary_10_1002_bit_21929
crossref_primary_10_1016_0378_5173_90_90008_R
crossref_primary_10_1016_j_carbon_2011_08_074
crossref_primary_10_1080_07328319708002524
crossref_primary_10_1016_0301_4622_91_85013_G
crossref_primary_10_1016_S0005_2736_02_00507_2
crossref_primary_10_1016_S0162_0134_96_00096_7
crossref_primary_10_1152_ajpcell_00285_2013
crossref_primary_10_3390_pr8060642
crossref_primary_10_1002_bmc_1130040408
crossref_primary_10_1007_s12274_017_1705_1
crossref_primary_10_1135_cccc2009512
crossref_primary_10_1016_1040_8428_94_00131_C
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
DOI 10.1007/BF02086146
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Chemistry
Pharmacy, Therapeutics, & Pharmacology
ExternalDocumentID 3520474
Genre Journal Article
Review
GroupedDBID -IN
123
203
28-
29~
2J2
2KG
5QI
95-
95.
95~
96X
ABJNI
ABQSL
ACGFS
ADHKG
AEFIE
AJRNO
ALMA_UNASSIGNED_HOLDINGS
AMKLP
ASPBG
AVWKF
AZFZN
B-.
BA0
BBWZM
CGR
CS3
CUY
CVF
ECM
EIF
F5P
GQ8
I~Z
KOW
MA-
N2Q
NPM
PF0
QOK
QOR
RHV
ROL
SAP
SZN
TSV
TUC
WK6
ID FETCH-LOGICAL-c197t-b677c77cea1a3cbf77546a5fbbc730ceabaf7fce6a610620836d00975d4a1d792
ISSN 0167-6555
IngestDate Tue Aug 05 11:34:36 EDT 2025
IsPeerReviewed false
IsScholarly false
Issue 2
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c197t-b677c77cea1a3cbf77546a5fbbc730ceabaf7fce6a610620836d00975d4a1d792
PMID 3520474
ParticipantIDs pubmed_primary_3520474
PublicationCentury 1900
PublicationDate 1986-Apr-25
PublicationDateYYYYMMDD 1986-04-25
PublicationDate_xml – month: 04
  year: 1986
  text: 1986-Apr-25
  day: 25
PublicationDecade 1980
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Pharmaceutisch weekblad. Scientific edition
PublicationTitleAlternate Pharm Weekbl Sci
PublicationYear 1986
SSID ssj0000502655
Score 1.237181
SecondaryResourceType review_article
Snippet A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic...
SourceID pubmed
SourceType Index Database
StartPage 109
SubjectTerms Adsorption
Antibiotics, Antineoplastic - analysis
Chemical Phenomena
Chemistry
Chemistry, Physical
Chromatography, High Pressure Liquid
Drug Stability
Metals - analysis
Naphthacenes - analysis
Solubility
Spectrophotometry
Title Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties
URI https://www.ncbi.nlm.nih.gov/pubmed/3520474
Volume 8
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9tAEF4FEIJLVV6iLa32gLgkjmzj9eOYoFaIA-IQVG5odr0rWvIScVS5N_45sw_HTmgRIEWWtatYiefzemZ2vm8IOWYgQz_izFOpwAAlOvU9wLDAC1QkhM-k9G21xWV8fh1d3LCbVuuxyS4peFf8_Sev5D1WxTG0q2bJvsGyi4viAJ6jffGIFsbjq2xsuhyAKIXxFUEzbucYyj-0QROmZl186mtqis1h6AZZRiHAlm3CsCwWegHoKJpS2VJXbU11wbUrMHTO69XdIv-NMXH7j5T3fAh51y4Qpuioje_C5tZ-fzIfwdLuU1_--j12jJCaGdGfD4ulzKrpx1TVnv10X88tXS-N9UaLZTJXCUtciGNmpXirFTdtACtsrJ6BUUp4vqr7Va16iAGYS1k2zDsdGfuiK-lHtuXPi5Mr-tpuZo2sYaChO6e6dI8Vh8cQlbFKH17_j2WJW_eDtsmmu8xKdGK8lMFH8sGFF7RnsbJDWnK8S7bOqq5-u-TEGbHs0EFNvZt16Am9qlXMyz0CS-CiNbioAxftUQsuOlF0BVwdWkMLT3O6gBatobVPrn98H5yde64fhyeCLCk8HieJwI-EAE4FV1o8MQamOBf4nsBhDipRQsaAPnkcat3zXPOEWB5BkCdZeEDWx5OxPCQ0ZxlPFQ_RU-CRYgA-Tqciw0tngDH1J3Jgb-Pt1Iqu3Lr7-_l_E1_Ido2_I7Kh8BmXX9FhLPg3Y9QnVZ5uCA
linkProvider National Library of Medicine
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Anthracycline+antitumour+agents.+A+review+of+physicochemical%2C+analytical+and+stability+properties&rft.jtitle=Pharmaceutisch+weekblad.+Scientific+edition&rft.au=Bouma%2C+J&rft.au=Beijnen%2C+J+H&rft.au=Bult%2C+A&rft.au=Underberg%2C+W+J&rft.date=1986-04-25&rft.issn=0167-6555&rft.volume=8&rft.issue=2&rft.spage=109&rft_id=info:doi/10.1007%2FBF02086146&rft_id=info%3Apmid%2F3520474&rft_id=info%3Apmid%2F3520474&rft.externalDocID=3520474
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0167-6555&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0167-6555&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0167-6555&client=summon