Differential effects of the D1-DA receptor antagonist SCH39166 on positive and negative symptoms of schizophrenia

• Published in: Psychopharmacology Vol. 121; no. 3; p. 317
• Main Authors: Den Boer, J A, van Megen, H J, Fleischhacker, W W, Louwerens, J W, Slaap, B R, Westenberg, H G, Burrows, G D, Srivastava, O N
• Format: Journal Article
• Language: English
• Published: Germany 01.10.1995
• Subjects: Administration, Oral; Adult; Antipsychotic Agents - pharmacology; Dopamine Antagonists - therapeutic use; Female; Humans; Male; Psychiatric Status Rating Scales; Receptors, Dopamine D1 - antagonists & inhibitors; Schizophrenia - drug therapy

In the present open study the effects of the D1-dopamine antagonist SCH 39166 on positive and negative symptoms of schizophrenia (DSM-IIIR) were investigated. SCH 39166 was given orally according to a fixed dosage schedule (day 1: 25 mg b.i.d; day 4: 50 mg b.i.d.; day 7: 100 mg b.i.d.; day 18: 200 m...