Continuous flow coupling reaction of bromopyridine and styrene catalyzed by amidoxime fiber supported-palladium

Polyacrylonitrile (PAN) fibers were modified by hydroxylamine to obtain amidoxime fibers (AOFs) as the carrier, which was coordinated with PdCl2 solution to prepare amidoxime fibers supported Pd(II) [AOFs-Pd(II)] catalyst. A continuous flow reaction device was established to explore the coupling rea...

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Bibliographic Details
Published inTetrahedron Vol. 152; pp. 133816 - 133821
Main Authors Ding, Zhen, Xu, Maodong, Xie, Jiaxin, Zhang, Yilin, Lu, Xiaohan, Lu, Siyu, Tao, Tingxian, Wu, Zhichuan
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 15.02.2024
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Amidoxime fiber
Palladium catalyst
Coupling reaction
Continuous flow
Kinetic equation
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Summary:Polyacrylonitrile (PAN) fibers were modified by hydroxylamine to obtain amidoxime fibers (AOFs) as the carrier, which was coordinated with PdCl2 solution to prepare amidoxime fibers supported Pd(II) [AOFs-Pd(II)] catalyst. A continuous flow reaction device was established to explore the coupling reaction of bromopyridine with styrene catalyzed by AOFs-Pd(II). The optimization was carried out to obtain the optimal process conditions, including temperature, flow rate, substrate concentration, catalyst stability, substrate applicability. The kinetic equations under continuous flow were obtained by fitting the data from the experiments using Matlab, and the reaction was determined to be a first-order reaction. Using the Arrhenius equation, the activation energy (Ea) was determined to be 7.65 kJ/mol.
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2023.133816