Pharmacokinetics of reshaped MAb 425 in three animal species

• Published in: Cell biophysics Vol. 26; no. 3; p. 167
• Main Authors: Haunschild, J, Steiner, K, Faro, H P, Senekowitsch, R
• Format: Journal Article
• Language: English
• Published: United States 01.06.1995
• Subjects: Animals; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacokinetics; Autoradiography; Half-Life; Haplorhini; Humans; Iodine Radioisotopes; Mice; Mice, Nude; Rats; Receptor, Epidermal Growth Factor - immunology; Species Specificity; Tissue Distribution; Tumor Cells, Cultured

The murine monoclonal antibody (MAb) 425 (mMAb 425) directed against the human EGFR (epidermal growth factor receptor) was reshaped (rMAb 425) in order to improve its therapeutical potential in humans. The pharmacokinetic properties of [125I]-mMAb and [125I]-rMAb 425 were compared in three animal sp...