Efficacy and Safety of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil Fumarate (TDF) Followed by TAF in Chronic Hepatitis B Patients of East Asian Ethnicity Following 5 Years of Treatment

• Published in: Alimentary pharmacology & therapeutics
• Main Authors: Wong, Grace Lai‐Hung, Gane, Edward, Pan, Calvin Q., Fung, Scott, Ma, Mang M., Izumi, Namiki, Shalimar, Lim, Seng Gee, Chuang, Wan‐Long, Mehta, Rajiv, Lim, Young‐Suk, Yee, Leland J., Flaherty, John F., Abramov, Frida, Wang, Hongyuan, Buti, Maria
• Format: Journal Article
• Language: English
• Published: England 12.08.2025
• Subjects: ALT normalisation; tenofovir alafenamide; tenofovir disoproxil fumarate; hepatitis B

Tenofovir alafenamide (TAF) has shown non-inferior efficacy to tenofovir disoproxil fumarate (TDF), with superior bone and renal safety. To characterise 5-year TAF efficacy and safety in patients of East Asian ethnicity from pivotal Phase 3 studies. Patients were randomised (2:1) to receive TAF or T...