Interferon ɛ restricts Zika virus infection in the female reproductive tract

• Published in: PNAS nexus Vol. 2; no. 11; p. pgad350
• Main Authors: Xu, Chuan, Wang, Annie, Ebraham, Laith, Sullivan, Liam, Tasker, Carley, Pizutelli, Vanessa, Couret, Jennifer, Hernandez, Cyril, Kolli, Priyanka, Deb, Pratik Q, Fritzky, Luke, Subbian, Selvakumar, Gao, Nan, Lo, Yungtai, Salvatore, Mirella, Rivera, Amariliz, Lemenze, Alexander, Fitzgerald-Bocarsly, Patricia, Tyagi, Sanjay, Lu, Wuyuan, Beaulieu, Aimee, Chang, Theresa L
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2023
• Subjects: Biological, Health, and Medical Sciences

Interferon ɛ (IFNɛ) is a unique type I IFN that has been implicated in host defense against sexually transmitted infections. Zika virus (ZIKV), an emerging pathogen, can infect the female reproductive tract (FRT) and cause devastating diseases, particularly in pregnant women. How IFNɛ contributes to...