Risk factors and crucial prognostic indicators of mortality in liver transplant recipients with bloodstream infections: A comprehensives study of 1049 consecutive liver transplants over an 11-year period

• Published in: Journal of microbiology, immunology and infection Vol. 57; no. 5; pp. 771 - 781
• Main Authors: Lee, Ing-Kit, Chang, Po-Hsun, Yeh, Cheng-Hsi, Li, Wei-Feng, Yin, Shih-Min, Lin, Yu-Cheng, Tzeng, Wei-Juo, Chen, Chao-Long, Lin, Chih-Che, Wang, Chih-Chi
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.10.2024
• Subjects: Adult; Aged; Bacteremia - microbiology; Bacteremia - mortality; Bloodstream infections; End Stage Liver Disease - mortality; End Stage Liver Disease - surgery; Female; Hospital Mortality; Humans; Liver transplantation; Liver Transplantation - adverse effects; Liver Transplantation - mortality; Male; Middle Aged; Mortality; Postoperative Complications - epidemiology; Postoperative Complications - mortality; Prognosis; Retrospective Studies; Risk factor; Risk Factors; Transplant Recipients - statistics & numerical data; Bloodstream infections; Mortality; Risk factor; Liver transplantation
• ISSN: 1684-1182; 1995-9133; 1995-9133
• DOI: 10.1016/j.jmii.2024.06.002

Liver transplantation (LT) is a pivotal treatment for end-stage liver disease. However, bloodstream infections (BSI) in the post-operative period present a significant threat to patient survival. This study aims to identify risk factors for post-LT BSI and crucial prognostic indicators for mortality among affected patients. We conducted a retrospective study of adults diagnosed with end-stage liver disease who underwent their initial LT between 2010 and 2021. Those who developed BSI post-LT during the same hospital admission were classified into the BSI group. In this cohort of 1049 patients, 89 (8.4%) developed BSI post-LT, while 960 (91.5%) did not contract any infection. Among the BSI cases, 17 (19.1%) patients died. The average time to BSI onset was 48 days, with 46% occurring within the first month post-LT. Of the 123 isolated microorganisms, 97 (78.8%) were gram-negative bacteria. BSI patients had significantly longer stays in the intensive care unit and hospital compared to non-infected patients. The 90-day and in-hospital mortality rates for recipients with BSI were significantly higher than those without infections. Multivariate analysis indicated heightened BSI risk in patients with blood loss >3000 mL during LT (odds ratio [OR] 2.128), re-operation within 30 days (OR 2.341), post-LT bile leakage (OR 3.536), and graft rejection (OR 2.194). Additionally, chronic kidney disease (OR 6.288), each 1000 mL increase in intraoperative blood loss (OR 1.147) significantly raised mortality risk in BSI patients, whereas each 0.1 mg/dL increase in albumin levels correlated with a lower risk of death from BSI (OR 0.810). This study underscores the need for careful monitoring and management in the post-LT period, especially for patients at higher risk of BSI. It also suggests that serum albumin levels could serve as a valuable prognostic indicator for outcomes in LT recipients experiencing BSI.