New concept for neutron dosimetry in ion beam radiotherapy: Feasibility study

In ion beam radiotherapy (IBRT), the secondary neutrons contribute to whole-body exposure, potentially increasing the risk of radiation-induced cancer. The energy range of neutrons generated in the IBRT treatment room spreads from thermal to a few hundred MeV, with those between 0.1 and a few hundre...

Full description

Saved in:
Bibliographic Details
Published inRadiation physics and chemistry (Oxford, England : 1993) Vol. 223; p. 112014
Main Authors Aoki, Katsumi, Yonai, Shunsuke
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.10.2024
Subjects
Online AccessGet full text

Cover

Loading…
Abstract In ion beam radiotherapy (IBRT), the secondary neutrons contribute to whole-body exposure, potentially increasing the risk of radiation-induced cancer. The energy range of neutrons generated in the IBRT treatment room spreads from thermal to a few hundred MeV, with those between 0.1 and a few hundred MeV playing a crucial role in the ambient dose equivalent. This study introduces a novel approach for measuring the ambient dose equivalent that focuses on the neutron energy spectrum in the IBRT treatment room. Distinguished by the use of a hydrogen-filled proportional counter and a single moderator, this new method overcomes the weakness of the traditional Bonner Sphere Spectrometer by reducing the complexity and time required for measurements. By deriving the neutron energy spectrum, the neutron ambient dose equivalent can be accurately calculated. Our validation demonstrated that the neutron ambient dose equivalents derived using our method closely agree with the actual values, with discrepancies within 4%, underscoring the feasibility of this innovative approach to neutron dosimetry in the IBRT treatment room. •A new concept for the experimental determination of neutron H*(10) is proposed.•The H*(10) is determined based on the energy spectrum through a single measurement.•This method overcomes the weakness of the conventional measurement method.•Our validation showed that this method reproduces the actual values well.•These findings affirm the practicality of the method in the IBRT treatment room.
AbstractList In ion beam radiotherapy (IBRT), the secondary neutrons contribute to whole-body exposure, potentially increasing the risk of radiation-induced cancer. The energy range of neutrons generated in the IBRT treatment room spreads from thermal to a few hundred MeV, with those between 0.1 and a few hundred MeV playing a crucial role in the ambient dose equivalent. This study introduces a novel approach for measuring the ambient dose equivalent that focuses on the neutron energy spectrum in the IBRT treatment room. Distinguished by the use of a hydrogen-filled proportional counter and a single moderator, this new method overcomes the weakness of the traditional Bonner Sphere Spectrometer by reducing the complexity and time required for measurements. By deriving the neutron energy spectrum, the neutron ambient dose equivalent can be accurately calculated. Our validation demonstrated that the neutron ambient dose equivalents derived using our method closely agree with the actual values, with discrepancies within 4%, underscoring the feasibility of this innovative approach to neutron dosimetry in the IBRT treatment room. •A new concept for the experimental determination of neutron H*(10) is proposed.•The H*(10) is determined based on the energy spectrum through a single measurement.•This method overcomes the weakness of the conventional measurement method.•Our validation showed that this method reproduces the actual values well.•These findings affirm the practicality of the method in the IBRT treatment room.
ArticleNumber 112014
Author Aoki, Katsumi
Yonai, Shunsuke
Author_xml – sequence: 1
  givenname: Katsumi
  orcidid: 0009-0007-1918-2253
  surname: Aoki
  fullname: Aoki, Katsumi
  email: katsumi.aoki@riken.jp
– sequence: 2
  givenname: Shunsuke
  surname: Yonai
  fullname: Yonai, Shunsuke
BookMark eNqN0M9KAzEQBvAgCrbVd4gPsGv-7XbjTYpVoepFwVtIshOa0t0sSars27ulHjx6Ghj4vhl-c3Tehx4QuqGkpITWt7sy6nbYjsluoSsZYaKklBEqztCMNktZkEZW52hGZC2LhtSfl2ie0o4QsmwqPkMvr_CNbegtDBm7EHEPhxxDj9uQfAc5jtj32E8LA7rD0zEf8haiHsY7vAadvPF7n0ec8qEdr9CF0_sE179zgT7WD--rp2Lz9vi8ut8UlsoqF8YYK1xlWkMFVKC5tiAEGEmdlERbXlNnBHADjRCcshpYRcE4wUndEMb4AslTr40hpQhODdF3Oo6KEnV0UTv1x0UdXdTJZcquTlmYHvzyEFWyHiaA1kewWbXB_6PlBxQhdcE
Cites_doi 10.1080/00223131.2023.2275736
10.1016/j.radmeas.2022.106755
10.1259/bjr.20130626
10.1016/j.radphyschem.2020.108787
10.1016/j.radonc.2007.12.003
10.1118/1.2989019
10.1016/j.ejmp.2017.04.022
10.1016/j.ijrobp.2006.01.027
10.1097/00004032-200008000-00010
10.1016/j.radmeas.2010.08.015
10.1002/mp.13864
10.1016/j.ejmp.2018.04.391
10.1016/j.radmeas.2010.05.006
10.1118/1.4736823
10.1016/S1470-2045(06)70795-1
10.1038/nrc3069
10.1093/rpd/ncaa166
10.1002/mp.12462
10.1118/1.4916667
10.1016/S0168-9002(01)01379-1
10.1093/rpd/nct251
10.1093/rpd/ncm154
10.14407/jrpr.2020.00276
10.1118/1.3458721
10.1088/0031-9155/54/7/009
10.1080/18811248.2011.9711675
ContentType Journal Article
Copyright 2024 Elsevier Ltd
Copyright_xml – notice: 2024 Elsevier Ltd
DBID AAYXX
CITATION
DOI 10.1016/j.radphyschem.2024.112014
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
Physics
EISSN 1879-0895
ExternalDocumentID 10_1016_j_radphyschem_2024_112014
S0969806X24005061
GroupedDBID ---
--K
--M
.~1
0R~
123
1B1
1RT
1~.
1~5
29P
4.4
457
4G.
53G
5VS
7-5
71M
8P~
8WZ
9JN
A6W
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AAXUO
ABFNM
ABJNI
ABMAC
ABNEU
ABXDB
ACDAQ
ACFVG
ACGFS
ACIWK
ACNCT
ACNNM
ACRLP
ADBBV
ADEZE
ADMUD
AEBSH
AEKER
AENEX
AFKWA
AFTJW
AGHFR
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AIVDX
AJOXV
AKRWK
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BBWZM
BKOJK
BLXMC
CS3
EBS
EFJIC
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
HMV
HVGLF
HZ~
IHE
J1W
KOM
M38
M41
MO0
N9A
NDZJH
O-L
O9-
OAUVE
OGIMB
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
RNS
ROL
RPZ
SDF
SDG
SDP
SES
SEW
SPC
SPCBC
SPD
SPG
SSQ
SSZ
T5K
WUQ
XPP
~G-
AAXKI
AAYXX
CITATION
ID FETCH-LOGICAL-c195t-bbbc4f5bdb14e5ea3ace44eb91f990ac361fb4e3be8443126e251ebf430680223
IEDL.DBID .~1
ISSN 0969-806X
IngestDate Thu Sep 12 21:16:55 EDT 2024
Sat Jul 27 15:42:00 EDT 2024
IsPeerReviewed true
IsScholarly true
Keywords Neutron energy spectrum
Carbon-ion radiotherapy
Secondary neutron
Neutron dosimetry
Hydrogen-filled proportional counter
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c195t-bbbc4f5bdb14e5ea3ace44eb91f990ac361fb4e3be8443126e251ebf430680223
ORCID 0009-0007-1918-2253
ParticipantIDs crossref_primary_10_1016_j_radphyschem_2024_112014
elsevier_sciencedirect_doi_10_1016_j_radphyschem_2024_112014
PublicationCentury 2000
PublicationDate October 2024
2024-10-00
PublicationDateYYYYMMDD 2024-10-01
PublicationDate_xml – month: 10
  year: 2024
  text: October 2024
PublicationDecade 2020
PublicationTitle Radiation physics and chemistry (Oxford, England : 1993)
PublicationYear 2024
Publisher Elsevier Ltd
Publisher_xml – name: Elsevier Ltd
References Halperin (bib7) 2006; 7
Yonai, Matsumoto (bib31) 2021; 46
Farah, Mares, Romero‐Expósito, Trinkl, Domingo, Dufek, Klodowska, Kubancak, Knežević, Liszka, Majer, Miljanić, Ploc, Schinner, Stolarczyk, Trompier, Wielunski, Olko, Harrison (bib3) 2015; 42
Thomas, Alevra (bib21) 2002; 476
Brenner, Hall (bib1) 2008; 86
(bib9) 2014
Gómez-Ros, Bedogni, Domingo, Eakins, Roberts, Tanner (bib5) 2022; 153
Yonai, Matsufuji, Kanai, Matsui, Matsushita (bib26) 2010; 45
(bib8) 1996; 26
Kunieda, Iwamoto, Iwamoto, Minato, Okamoto, Sato, Nakashima, Iwamoto, Iwamoto, Kitatani, Fukahori, Watanabe, Shigyo, Chiba, Yamano, Hagiwara, Niita, Kosako, Hirayama, Murata (bib11) 2016
Yonai, Matsufuji, Akahane (bib29) 2018; 51
Olsher, Hsu, Beverding, Kleck, Casson, Vasilik, Devine (bib16) 2000; 79
Trompier, Delacroix, Vabre, Joussard, Proust (bib22) 2007; 125
Yonai, Kase, Matsufuji, Kanai, Nishio, Namba, Yamashita (bib25) 2010; 37
Yonai, Furukawa, Inaniwa (bib28) 2014; 161
Shibata, Iwamoto, Nakagawa, Iwamoto, Ichihara, Kunieda, Chiba, Furutaka, Otuka, Ohsawa, Murata, Matsunobu, Zukeran, Kamada, Katakura (bib19) 2011; 48
Sato, Endo, Zankl, Petoussi-Henss, Niita (bib17) 2009; 54
Sato, Iwamoto, Hashimoto, Ogawa, Furuta, Abe, Kai, Matsuya, Matsuda, Hirata, Sekikawa, Yao, Tsai, Ratliff, Iwase, Sakaki, Sugihara, Shigyo, Sihver, Niita (bib18) 2024; 61
Garny, Mares, Roos, Wagner, Rühm (bib4) 2011; 46
Yonai, Matsumoto (bib30) 2020; 172
Stokkevåg, Schneider, Muren, Newhauser (bib20) 2017; 42
Wiegel, Alevra (bib23) 2002
Durante (bib2) 2014; 87
Matsumoto, Yonai (bib13) 2020; 191
Yonai, Matsufuji, Kanai, Matsui, Matsushita, Yamashita, Numano, Sakae, Terunuma, Nishio, Kohno, Akagi (bib24) 2008; 35
Matsumoto, Yonai, Bolch (bib12) 2019; 46
Kry, Bednarz, Howell, Dauer, Followill, Klein, Paganetti, Wang, Wuu, George Xu (bib10) 2017; 44
Matzke (bib14) 1994
Newhauser, Durante (bib15) 2011; 11
Yonai, Matsufuji, Namba (bib27) 2012; 39
Hall (bib6) 2006; 65
Kunieda (10.1016/j.radphyschem.2024.112014_bib11) 2016
Hall (10.1016/j.radphyschem.2024.112014_bib6) 2006; 65
Yonai (10.1016/j.radphyschem.2024.112014_bib28) 2014; 161
Gómez-Ros (10.1016/j.radphyschem.2024.112014_bib5) 2022; 153
Farah (10.1016/j.radphyschem.2024.112014_bib3) 2015; 42
(10.1016/j.radphyschem.2024.112014_bib9) 2014
Newhauser (10.1016/j.radphyschem.2024.112014_bib15) 2011; 11
Matsumoto (10.1016/j.radphyschem.2024.112014_bib12) 2019; 46
Yonai (10.1016/j.radphyschem.2024.112014_bib27) 2012; 39
Thomas (10.1016/j.radphyschem.2024.112014_bib21) 2002; 476
Shibata (10.1016/j.radphyschem.2024.112014_bib19) 2011; 48
Trompier (10.1016/j.radphyschem.2024.112014_bib22) 2007; 125
Matzke (10.1016/j.radphyschem.2024.112014_bib14) 1994
Yonai (10.1016/j.radphyschem.2024.112014_bib24) 2008; 35
Durante (10.1016/j.radphyschem.2024.112014_bib2) 2014; 87
Yonai (10.1016/j.radphyschem.2024.112014_bib30) 2020; 172
Olsher (10.1016/j.radphyschem.2024.112014_bib16) 2000; 79
Sato (10.1016/j.radphyschem.2024.112014_bib17) 2009; 54
Garny (10.1016/j.radphyschem.2024.112014_bib4) 2011; 46
Sato (10.1016/j.radphyschem.2024.112014_bib18) 2024; 61
Matsumoto (10.1016/j.radphyschem.2024.112014_bib13) 2020; 191
(10.1016/j.radphyschem.2024.112014_bib8) 1996; 26
Wiegel (10.1016/j.radphyschem.2024.112014_bib23) 2002
Yonai (10.1016/j.radphyschem.2024.112014_bib29) 2018; 51
Brenner (10.1016/j.radphyschem.2024.112014_bib1) 2008; 86
Halperin (10.1016/j.radphyschem.2024.112014_bib7) 2006; 7
Stokkevåg (10.1016/j.radphyschem.2024.112014_bib20) 2017; 42
Yonai (10.1016/j.radphyschem.2024.112014_bib31) 2021; 46
Yonai (10.1016/j.radphyschem.2024.112014_bib26) 2010; 45
Kry (10.1016/j.radphyschem.2024.112014_bib10) 2017; 44
Yonai (10.1016/j.radphyschem.2024.112014_bib25) 2010; 37
References_xml – volume: 61
  start-page: 127
  year: 2024
  end-page: 135
  ident: bib18
  article-title: Recent improvements of the particle and heavy ion transport code system – PHITS version 3.33
  publication-title: J. Nucl. Sci. Technol.
  contributor:
    fullname: Niita
– volume: 46
  start-page: 5824
  year: 2019
  end-page: 5832
  ident: bib12
  article-title: Monte Carlo study of out-of-field exposure in carbon-ion radiotherapy: organ doses in pediatric brain tumor treatment
  publication-title: Med. Phys.
  contributor:
    fullname: Bolch
– volume: 51
  start-page: 48
  year: 2018
  end-page: 55
  ident: bib29
  article-title: Monte Carlo study of out-of-field exposure in carbon-ion radiotherapy with a passive beam: organ doses in prostate cancer treatment
  publication-title: Phys. Med.
  contributor:
    fullname: Akahane
– volume: 11
  start-page: 438
  year: 2011
  end-page: 448
  ident: bib15
  article-title: Assessing the risk of second malignancies after modern radiotherapy
  publication-title: Nat. Rev. Cancer
  contributor:
    fullname: Durante
– volume: 191
  start-page: 310
  year: 2020
  end-page: 318
  ident: bib13
  article-title: Evaluation of neutron ambient dose equivalent in carbon-ion radiotherapy with energy scanning
  publication-title: Radiat. Protect. Dosim.
  contributor:
    fullname: Yonai
– volume: 35
  start-page: 4782
  year: 2008
  end-page: 4792
  ident: bib24
  article-title: Measurement of neutron ambient dose equivalent in passive carbon‐ion and proton radiotherapies
  publication-title: Med. Phys.
  contributor:
    fullname: Akagi
– volume: 46
  start-page: 39
  year: 2021
  end-page: 47
  ident: bib31
  article-title: Secondary neutron dose in carbon-ion radiotherapy: investigations in QST–NIRS
  publication-title: Journal of Radiation Protection and Research
  contributor:
    fullname: Matsumoto
– volume: 37
  start-page: 4046
  year: 2010
  end-page: 4055
  ident: bib25
  article-title: Measurement of absorbed dose, quality factor, and dose equivalent in water phantom outside of the irradiation field in passive carbon‐ion and proton radiotherapies
  publication-title: Med. Phys.
  contributor:
    fullname: Yamashita
– volume: 86
  start-page: 165
  year: 2008
  end-page: 170
  ident: bib1
  article-title: Secondary neutrons in clinical proton radiotherapy: a charged issue
  publication-title: Radiother. Oncol.
  contributor:
    fullname: Hall
– start-page: 41
  year: 2016
  end-page: 46
  ident: bib11
  article-title: Overview of JENDL-4.0/HE and benchmark calculations
  publication-title: JAEA-conf 2016–004
  contributor:
    fullname: Murata
– volume: 65
  start-page: 1
  year: 2006
  end-page: 7
  ident: bib6
  article-title: Intensity-modulated radiation therapy, protons, and the risk of second cancers
  publication-title: Int. J. Radiat. Oncol. Biol. Phys.
  contributor:
    fullname: Hall
– volume: 26
  year: 1996
  ident: bib8
  article-title: Conversion coefficients for use in radiological protection against external radiation. ICRP publication 74
  publication-title: Ann. ICRP
– year: 1994
  ident: bib14
  article-title: Unfolding of Pulse Height Spectra: the HEPRO Program System
  contributor:
    fullname: Matzke
– volume: 42
  start-page: 259
  year: 2017
  end-page: 262
  ident: bib20
  article-title: Radiation-induced cancer risk predictions in proton and heavy ion radiotherapy
  publication-title: Phys. Med.
  contributor:
    fullname: Newhauser
– volume: 46
  start-page: 92
  year: 2011
  end-page: 97
  ident: bib4
  article-title: Measurement of neutron spectra and neutron doses at the Munich FRM II therapy beam with Bonner spheres
  publication-title: Radiat. Meas.
  contributor:
    fullname: Rühm
– volume: 39
  start-page: 5028
  year: 2012
  end-page: 5039
  ident: bib27
  article-title: Calculation of out-of-field dose distribution in carbon-ion radiotherapy by Monte Carlo simulation
  publication-title: Med. Phys.
  contributor:
    fullname: Namba
– volume: 54
  start-page: 1997
  year: 2009
  end-page: 2014
  ident: bib17
  article-title: Fluence-to-dose conversion coefficients for neutrons and protons calculated using the PHITS code and ICRP/ICRU adult reference computational phantoms
  publication-title: Phys. Med. Biol.
  contributor:
    fullname: Niita
– volume: 172
  year: 2020
  ident: bib30
  article-title: Monte Carlo study toward the development of a radiation field to simulate secondary neutrons produced in carbon-ion radiotherapy
  publication-title: Radiat. Phys. Chem.
  contributor:
    fullname: Matsumoto
– volume: 125
  start-page: 349
  year: 2007
  end-page: 354
  ident: bib22
  article-title: Secondary exposure for 73 and 200 MeV proton therapy
  publication-title: Radiat. Protect. Dosim.
  contributor:
    fullname: Proust
– year: 2014
  ident: bib9
  article-title: Medical electrical equipment. Part 2–64
  publication-title: Particular Requirements for the Basic Safety and Essential Performance of Light Ion Beam Medical Electrical Equipment
– volume: 7
  start-page: 676
  year: 2006
  end-page: 685
  ident: bib7
  article-title: Particle therapy and treatment of cancer
  publication-title: Lancet Oncol.
  contributor:
    fullname: Halperin
– volume: 79
  start-page: 170
  year: 2000
  end-page: 181
  ident: bib16
  article-title: WENDI: an improved neutron rem meter
  publication-title: Health Phys.
  contributor:
    fullname: Devine
– volume: 48
  start-page: 1
  year: 2011
  end-page: 30
  ident: bib19
  article-title: JENDL-4.0: a new library for nuclear science and engineering
  publication-title: J. Nucl. Sci. Technol.
  contributor:
    fullname: Katakura
– year: 2002
  ident: bib23
  article-title: NEMUSFthe PTB Neutron Multisphere Spectrometer: Bonner Spheres and More
  contributor:
    fullname: Alevra
– volume: 42
  start-page: 2572
  year: 2015
  end-page: 2584
  ident: bib3
  article-title: Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems
  publication-title: Med. Phys.
  contributor:
    fullname: Harrison
– volume: 153
  year: 2022
  ident: bib5
  article-title: Results of the EURADOS international comparison exercise on neutron spectra unfolding in Bonner spheres spectrometry
  publication-title: Radiat. Meas.
  contributor:
    fullname: Tanner
– volume: 87
  year: 2014
  ident: bib2
  article-title: New challenges in high-energy particle radiobiology
  publication-title: Br. J. Radiol.
  contributor:
    fullname: Durante
– volume: 45
  start-page: 1369
  year: 2010
  end-page: 1373
  ident: bib26
  article-title: Comparison of measured and calculated in-air secondary neutrons in passive carbon-ion radiotherapy
  publication-title: Radiat. Meas.
  contributor:
    fullname: Matsushita
– volume: 476
  start-page: 12
  year: 2002
  end-page: 20
  ident: bib21
  article-title: Bonner sphere spectrometers—a critical review
  publication-title: Nucl. Instrum. Methods Phys. Res., Sect. A: Accelerators, Spectrometers, Detectors and Associated Equipment, Int. Workshop on Neutron Field Spectrometry in Science, Technolog y and Radiation Protection
  contributor:
    fullname: Alevra
– volume: 44
  start-page: e391
  year: 2017
  end-page: e429
  ident: bib10
  article-title: Aapm tg 158: measurement and calculation of doses outside the treated volume from external-beam radiation therapy
  publication-title: Med. Phys.
  contributor:
    fullname: George Xu
– volume: 161
  start-page: 433
  year: 2014
  end-page: 436
  ident: bib28
  article-title: Measurement of neutron ambient dose equivalent in carbon-ion radiotherapy with an active scanned delivery system
  publication-title: Radiat. Protect. Dosim.
  contributor:
    fullname: Inaniwa
– year: 2014
  ident: 10.1016/j.radphyschem.2024.112014_bib9
  article-title: Medical electrical equipment. Part 2–64
– volume: 61
  start-page: 127
  year: 2024
  ident: 10.1016/j.radphyschem.2024.112014_bib18
  article-title: Recent improvements of the particle and heavy ion transport code system – PHITS version 3.33
  publication-title: J. Nucl. Sci. Technol.
  doi: 10.1080/00223131.2023.2275736
  contributor:
    fullname: Sato
– volume: 153
  year: 2022
  ident: 10.1016/j.radphyschem.2024.112014_bib5
  article-title: Results of the EURADOS international comparison exercise on neutron spectra unfolding in Bonner spheres spectrometry
  publication-title: Radiat. Meas.
  doi: 10.1016/j.radmeas.2022.106755
  contributor:
    fullname: Gómez-Ros
– start-page: 41
  year: 2016
  ident: 10.1016/j.radphyschem.2024.112014_bib11
  article-title: Overview of JENDL-4.0/HE and benchmark calculations
  publication-title: JAEA-conf 2016–004
  contributor:
    fullname: Kunieda
– volume: 87
  year: 2014
  ident: 10.1016/j.radphyschem.2024.112014_bib2
  article-title: New challenges in high-energy particle radiobiology
  publication-title: Br. J. Radiol.
  doi: 10.1259/bjr.20130626
  contributor:
    fullname: Durante
– volume: 172
  year: 2020
  ident: 10.1016/j.radphyschem.2024.112014_bib30
  article-title: Monte Carlo study toward the development of a radiation field to simulate secondary neutrons produced in carbon-ion radiotherapy
  publication-title: Radiat. Phys. Chem.
  doi: 10.1016/j.radphyschem.2020.108787
  contributor:
    fullname: Yonai
– volume: 86
  start-page: 165
  year: 2008
  ident: 10.1016/j.radphyschem.2024.112014_bib1
  article-title: Secondary neutrons in clinical proton radiotherapy: a charged issue
  publication-title: Radiother. Oncol.
  doi: 10.1016/j.radonc.2007.12.003
  contributor:
    fullname: Brenner
– volume: 26
  issue: 3–4
  year: 1996
  ident: 10.1016/j.radphyschem.2024.112014_bib8
  article-title: Conversion coefficients for use in radiological protection against external radiation. ICRP publication 74
  publication-title: Ann. ICRP
– volume: 35
  start-page: 4782
  year: 2008
  ident: 10.1016/j.radphyschem.2024.112014_bib24
  article-title: Measurement of neutron ambient dose equivalent in passive carbon‐ion and proton radiotherapies
  publication-title: Med. Phys.
  doi: 10.1118/1.2989019
  contributor:
    fullname: Yonai
– volume: 42
  start-page: 259
  year: 2017
  ident: 10.1016/j.radphyschem.2024.112014_bib20
  article-title: Radiation-induced cancer risk predictions in proton and heavy ion radiotherapy
  publication-title: Phys. Med.
  doi: 10.1016/j.ejmp.2017.04.022
  contributor:
    fullname: Stokkevåg
– volume: 65
  start-page: 1
  year: 2006
  ident: 10.1016/j.radphyschem.2024.112014_bib6
  article-title: Intensity-modulated radiation therapy, protons, and the risk of second cancers
  publication-title: Int. J. Radiat. Oncol. Biol. Phys.
  doi: 10.1016/j.ijrobp.2006.01.027
  contributor:
    fullname: Hall
– volume: 79
  start-page: 170
  year: 2000
  ident: 10.1016/j.radphyschem.2024.112014_bib16
  article-title: WENDI: an improved neutron rem meter
  publication-title: Health Phys.
  doi: 10.1097/00004032-200008000-00010
  contributor:
    fullname: Olsher
– volume: 46
  start-page: 92
  year: 2011
  ident: 10.1016/j.radphyschem.2024.112014_bib4
  article-title: Measurement of neutron spectra and neutron doses at the Munich FRM II therapy beam with Bonner spheres
  publication-title: Radiat. Meas.
  doi: 10.1016/j.radmeas.2010.08.015
  contributor:
    fullname: Garny
– volume: 46
  start-page: 5824
  year: 2019
  ident: 10.1016/j.radphyschem.2024.112014_bib12
  article-title: Monte Carlo study of out-of-field exposure in carbon-ion radiotherapy: organ doses in pediatric brain tumor treatment
  publication-title: Med. Phys.
  doi: 10.1002/mp.13864
  contributor:
    fullname: Matsumoto
– volume: 51
  start-page: 48
  year: 2018
  ident: 10.1016/j.radphyschem.2024.112014_bib29
  article-title: Monte Carlo study of out-of-field exposure in carbon-ion radiotherapy with a passive beam: organ doses in prostate cancer treatment
  publication-title: Phys. Med.
  doi: 10.1016/j.ejmp.2018.04.391
  contributor:
    fullname: Yonai
– volume: 45
  start-page: 1369
  year: 2010
  ident: 10.1016/j.radphyschem.2024.112014_bib26
  article-title: Comparison of measured and calculated in-air secondary neutrons in passive carbon-ion radiotherapy
  publication-title: Radiat. Meas.
  doi: 10.1016/j.radmeas.2010.05.006
  contributor:
    fullname: Yonai
– volume: 39
  start-page: 5028
  year: 2012
  ident: 10.1016/j.radphyschem.2024.112014_bib27
  article-title: Calculation of out-of-field dose distribution in carbon-ion radiotherapy by Monte Carlo simulation
  publication-title: Med. Phys.
  doi: 10.1118/1.4736823
  contributor:
    fullname: Yonai
– volume: 7
  start-page: 676
  year: 2006
  ident: 10.1016/j.radphyschem.2024.112014_bib7
  article-title: Particle therapy and treatment of cancer
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(06)70795-1
  contributor:
    fullname: Halperin
– volume: 11
  start-page: 438
  year: 2011
  ident: 10.1016/j.radphyschem.2024.112014_bib15
  article-title: Assessing the risk of second malignancies after modern radiotherapy
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3069
  contributor:
    fullname: Newhauser
– volume: 191
  start-page: 310
  year: 2020
  ident: 10.1016/j.radphyschem.2024.112014_bib13
  article-title: Evaluation of neutron ambient dose equivalent in carbon-ion radiotherapy with energy scanning
  publication-title: Radiat. Protect. Dosim.
  doi: 10.1093/rpd/ncaa166
  contributor:
    fullname: Matsumoto
– volume: 44
  start-page: e391
  year: 2017
  ident: 10.1016/j.radphyschem.2024.112014_bib10
  article-title: Aapm tg 158: measurement and calculation of doses outside the treated volume from external-beam radiation therapy
  publication-title: Med. Phys.
  doi: 10.1002/mp.12462
  contributor:
    fullname: Kry
– volume: 42
  start-page: 2572
  year: 2015
  ident: 10.1016/j.radphyschem.2024.112014_bib3
  article-title: Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems
  publication-title: Med. Phys.
  doi: 10.1118/1.4916667
  contributor:
    fullname: Farah
– volume: 476
  start-page: 12
  year: 2002
  ident: 10.1016/j.radphyschem.2024.112014_bib21
  article-title: Bonner sphere spectrometers—a critical review
  publication-title: Nucl. Instrum. Methods Phys. Res., Sect. A: Accelerators, Spectrometers, Detectors and Associated Equipment, Int. Workshop on Neutron Field Spectrometry in Science, Technolog y and Radiation Protection
  doi: 10.1016/S0168-9002(01)01379-1
  contributor:
    fullname: Thomas
– year: 2002
  ident: 10.1016/j.radphyschem.2024.112014_bib23
  contributor:
    fullname: Wiegel
– volume: 161
  start-page: 433
  year: 2014
  ident: 10.1016/j.radphyschem.2024.112014_bib28
  article-title: Measurement of neutron ambient dose equivalent in carbon-ion radiotherapy with an active scanned delivery system
  publication-title: Radiat. Protect. Dosim.
  doi: 10.1093/rpd/nct251
  contributor:
    fullname: Yonai
– year: 1994
  ident: 10.1016/j.radphyschem.2024.112014_bib14
  contributor:
    fullname: Matzke
– volume: 125
  start-page: 349
  year: 2007
  ident: 10.1016/j.radphyschem.2024.112014_bib22
  article-title: Secondary exposure for 73 and 200 MeV proton therapy
  publication-title: Radiat. Protect. Dosim.
  doi: 10.1093/rpd/ncm154
  contributor:
    fullname: Trompier
– volume: 46
  start-page: 39
  year: 2021
  ident: 10.1016/j.radphyschem.2024.112014_bib31
  article-title: Secondary neutron dose in carbon-ion radiotherapy: investigations in QST–NIRS
  publication-title: Journal of Radiation Protection and Research
  doi: 10.14407/jrpr.2020.00276
  contributor:
    fullname: Yonai
– volume: 37
  start-page: 4046
  year: 2010
  ident: 10.1016/j.radphyschem.2024.112014_bib25
  article-title: Measurement of absorbed dose, quality factor, and dose equivalent in water phantom outside of the irradiation field in passive carbon‐ion and proton radiotherapies
  publication-title: Med. Phys.
  doi: 10.1118/1.3458721
  contributor:
    fullname: Yonai
– volume: 54
  start-page: 1997
  year: 2009
  ident: 10.1016/j.radphyschem.2024.112014_bib17
  article-title: Fluence-to-dose conversion coefficients for neutrons and protons calculated using the PHITS code and ICRP/ICRU adult reference computational phantoms
  publication-title: Phys. Med. Biol.
  doi: 10.1088/0031-9155/54/7/009
  contributor:
    fullname: Sato
– volume: 48
  start-page: 1
  year: 2011
  ident: 10.1016/j.radphyschem.2024.112014_bib19
  article-title: JENDL-4.0: a new library for nuclear science and engineering
  publication-title: J. Nucl. Sci. Technol.
  doi: 10.1080/18811248.2011.9711675
  contributor:
    fullname: Shibata
SSID ssj0007853
Score 2.4337177
Snippet In ion beam radiotherapy (IBRT), the secondary neutrons contribute to whole-body exposure, potentially increasing the risk of radiation-induced cancer. The...
SourceID crossref
elsevier
SourceType Aggregation Database
Publisher
StartPage 112014
SubjectTerms Carbon-ion radiotherapy
Hydrogen-filled proportional counter
Neutron dosimetry
Neutron energy spectrum
Secondary neutron
Title New concept for neutron dosimetry in ion beam radiotherapy: Feasibility study
URI https://dx.doi.org/10.1016/j.radphyschem.2024.112014
Volume 223
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEB5KxcdFtCrWR1nB69qku9k24qUUS1XaixZ6C5nNBiI0LX0cevG3O5sHrSB48JaEXVi-2cx8u3wzA3BPe9b4kas4xkpwqToOx9B4PFQe2oe2H9qD4nCkBmP5OvEmFeiVuTBWVln4_tynZ966-NIs0GzOk6T5TuTb7zhqYlWQnpMdgSQFI9rTD19bmUe7k1eipMHcjj6Au63GaxFG9gKB4LFJ6S1pE2ocV_4eo3biTv8EjgvCyLr5mk6hYtIaHPbKPm012M9EnHp5BkPyWEzneYiMyChLzdredLNotkymhkazJGVkCIYmnDJaVlLkX20eGXHBQim7YVnN2XMY958_egNetEvg2vW9FUdELWMPI3Sl8UwoQm2kNOi7MYWcUAvlxiiNQNORRBtayhC3MRhLYftvEE24gGo6S80lMBS-iDS5AqF8Sfai3z6SytFkcRQq1nVolQAF87wqRlDKxT6DHVQDi2qQo1qHpxLK4IeJA_Lef0-_-t_0aziyb7kO7waqq8Xa3BKfWGEj2zAN2Ou-vA1G385czNk
link.rule.ids 315,786,790,4521,24144,27957,27958,45620,45714
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LSwMxEB5KxcdFtCrWZwSvsbtNNt0VL1IsVdtebKG3sMlmYYVuSx-HXvztTvZBKwgevC27EwjfZCdfwjczAPe4Zk0QuYKqWDDKhe9QFRqPhsJT9qEVhPag2B-I7oi_jb1xBdplLoyVVRaxP4_pWbQu3jQKNBuzJGl8IPkOfEeMrQrSc-wRaMfSedu_4eFro_No-XkpSrSm1nwP7jYir3kY2RsExMdmpTe5zahxXP77JrW18XSO4LBgjOQ5n9QxVExag_122aitBruZilMvTqCPIYvoPBGRIBslqVnZq24STRfJxKA1SVKCniDKhBOC00qKBKz1I0EyWEhl1yQrOnsKo87LsN2lRb8Eqt3AW1KllOaxpyLlcuOZkIXacG5U4Ma454SaCTdW3DBlfI68oSkMkhujYs5sAw7kCWdQTaepOQeiWMAijbGAiYCjw_C_j7hwNLpcMRHrOjRLgOQsL4shS73Yp9xCVVpUZY5qHZ5KKOUPH0sM338Pv_jf8FvY7w77Pdl7HbxfwoH9kovyrqC6nK_MNZKLpbrJFs83tlTOaw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=New+concept+for+neutron+dosimetry+in+ion+beam+radiotherapy%3A+Feasibility+study&rft.jtitle=Radiation+physics+and+chemistry+%28Oxford%2C+England+%3A+1993%29&rft.au=Aoki%2C+Katsumi&rft.au=Yonai%2C+Shunsuke&rft.date=2024-10-01&rft.pub=Elsevier+Ltd&rft.issn=0969-806X&rft.eissn=1879-0895&rft.volume=223&rft_id=info:doi/10.1016%2Fj.radphyschem.2024.112014&rft.externalDocID=S0969806X24005061
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0969-806X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0969-806X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0969-806X&client=summon