Cycles of Transcription and Translation Do Not Comprise the Gonadotropin-Releasing Hormone Pulse Generator in GT1 Cells

• Published in: Endocrinology (Philadelphia) Vol. 142; no. 5; pp. 1858 - 1864
• Main Authors: Pitts, Gilbert R., Nunemaker, Craig S., Moenter, Suzanne M.
• Format: Journal Article
• Language: English
• Published: 01.05.2001

Abstract Neural control of reproduction is achieved through episodic GnRH secretion, but little is known about the molecular mechanisms underlying pulse generation. The ultradian time domain of GnRH release suggests mechanisms ranging from macromolecular synthesis to posttranslational modification c...