AB0127 ANTIGENIC ASSESSMENT FOR THE Β2GPIOX-PF4 COMPLEX IN A MONOCENTRIC COHORT OF PATIENTS WITH APS, THROMBOSIS DURING SARS-COV-2 INFECTION AND VITT

• Published in: Annals of the rheumatic diseases Vol. 82; no. Suppl 1; p. 1243
• Main Authors: Ucci, F.M., Villani, F., Capozzi, A., De Michele, M., Truglia, S., Mancuso, S., Rapino, L., Tripodi, G., Manganelli, V., Riitano, G., Misasi, R., Sorice, M., Conti, F., Alessandri, C.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.06.2023; Elsevier Limited
• Subjects: Anti-phospholipid syndrome; Antibodies; Antiphospholipid syndrome; Autoantibodies; Autoantigens; Clotting; COVID-19; COVID-19 vaccines; Dimerization; Enzyme-linked immunosorbent assay; Glycoprotein I; Glycosaminoglycans; Heparin; Immune response; Immunogenicity; Infections; Phospholipids; Platelet factor 4; Platelets; Severe acute respiratory syndrome coronavirus 2; Thrombocytopenia; Thrombosis; Vaccination/Immunization; Vaccines; Anti-phospholipid syndrome; Autoantibodies; Vaccination/Immunization

Platelet factor 4 (PF4) is a protein with a pro-clotting function expressed by activated platelets with a high affinity for anionic glycosaminoglycans present on the platelet surface. It has been shown that the positively charged surface of PF4 tetramer interacts with the negatively charged regions...