Investigating the potential of minocycline in reducing brain inflammation in chronic low back pain: a randomized, placebo-controlled mechanistic clinical trial

• Published in: Pain (Amsterdam) Vol. 166; no. 9; pp. 2044 - 2053
• Main Authors: Mohammadian, Mehrbod, Morrissey, Erin J., Knight, Paulina C., Brusaferri, Ludovica, Kim, Minhae, Efthimiou, Nikolaos, Murphy, Jennifer P., Alshelh, Zeynab, Grmek, Grace, Schnieders, Jack H., Chane, Courtney A., Sandström, Angelica, Catana, Ciprian, Gilman, Jodi M., Locascio, Joseph J., Edwards, Robert R., Zhang, Yi, Napadow, Vitaly, Loggia, Marco L.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Wolters Kluwer 01.09.2025
• Subjects: Minocycline; Neuroinflammation; Chronic low back pain; Positron emission tomography; Translocator protein

Supplemental Digital Content is Available in the Text.Minocycline, a tetracycline antibiotic, may neither reduce translocator protein positron emission tomography signal nor clinical pain in adults with chronic low back pain compared with a placebo comparator. AbstractOur group has shown that transl...