POS1008 INVESTIGATING ANTIGEN SPECIFIC T CELLS AND THEIR CITRULLINATED PROTEIN TARGETS IN SYNOVIAL TISSUE

• Published in: Annals of the rheumatic diseases Vol. 82; no. Suppl 1; p. 820
• Main Authors: James, E.A., Rims, C., Posso, S., Carlin, J., Kwok, W., Ong, S.E., Buckner, J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.06.2023; Elsevier Limited
• Subjects: Adaptive immunity; Aggrecan; Antigens; Arthritis; Autoantigens; Autoimmune diseases; Caspase; CD4 antigen; CD69 antigen; CD8 antigen; CD95 antigen; Cell suspensions; Citrulline; Collagen; Collagenase; Fibrinogen; Fibroblasts; Fibronectin; Flow cytometry; Immunogenicity; Lymphocytes; Lymphocytes B; Lymphocytes T; Lysis; Peptides; Phenotypes; Proteins; Proteoglycans; Rheumatoid arthritis; Synovium; Rheumatoid arthritis; Adaptive immunity; Synovium

Rheumatoid arthritis (RA) is a T cell mediated autoimmune disease in which citrullinated self-antigens are recognized by anti-citrullinated protein antibodies (ACPA) and T cells. To date, the majority of T cell studies have been performed using peripheral blood and have focused on well-documented AC...