A CASE OF MIXED GONADAL DYSGENESIS ACCIDENTALLY DETECTED DURING TREATMENT FOR INGUINAL HERNIA

Mixed gonadal dysgenesis has a chromosomal aberration mainly due to 45X/46XY chromosomal mosaic, so the lateral gonad may be a testis and the contralateral a linear gonad with Müllerian duct rests including an undifferentiated vagina, uterus, and oviduct. Mixed gonadal dysgenesis is also associated...

Full description

Saved in:
Bibliographic Details
Published inNihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 65; no. 8; pp. 2210 - 2215
Main Authors KITAO, Yoshitaka, NAKAMURA, Ryuichi, MIYAGAKI, Takuya, YASUOKA, Rie, KADOTANI, Yoichi
Format Journal Article
LanguageEnglish
Published Japan Surgical Association 2004
Online AccessGet full text
ISSN1345-2843
1882-5133
DOI10.3919/jjsa.65.2210

Cover

Abstract Mixed gonadal dysgenesis has a chromosomal aberration mainly due to 45X/46XY chromosomal mosaic, so the lateral gonad may be a testis and the contralateral a linear gonad with Müllerian duct rests including an undifferentiated vagina, uterus, and oviduct. Mixed gonadal dysgenesis is also associated with certain physical features. Although it is principally treated by pediatric physicians and surgeons, we found it accidently in a 45-year-old patient being treated for inguinal hernia. After getting sufficiently informed consent, we successfully removed the linear gonad and Müllerian duct.
AbstractList Mixed gonadal dysgenesis has a chromosomal aberration mainly due to 45X/46XY chromosomal mosaic, so the lateral gonad may be a testis and the contralateral a linear gonad with Müllerian duct rests including an undifferentiated vagina, uterus, and oviduct. Mixed gonadal dysgenesis is also associated with certain physical features. Although it is principally treated by pediatric physicians and surgeons, we found it accidently in a 45-year-old patient being treated for inguinal hernia. After getting sufficiently informed consent, we successfully removed the linear gonad and Müllerian duct.
Author YASUOKA, Rie
KADOTANI, Yoichi
MIYAGAKI, Takuya
NAKAMURA, Ryuichi
KITAO, Yoshitaka
Author_xml – sequence: 1
  fullname: KITAO, Yoshitaka
  organization: Department of Surgery, Kyoto Nishijin Hospital
– sequence: 1
  fullname: NAKAMURA, Ryuichi
  organization: Department of Surgery, Kyoto Nishijin Hospital
– sequence: 1
  fullname: MIYAGAKI, Takuya
  organization: Department of Surgery, Kyoto Nishijin Hospital
– sequence: 1
  fullname: YASUOKA, Rie
  organization: Department of Surgery, Akashi City Hospital
– sequence: 1
  fullname: KADOTANI, Yoichi
  organization: Department of Surgery, Akashi City Hospital
BookMark eNo9kMtugzAQRa0qlZqm3fUD_AEl9YOHvbTAIUgEJCBSs6iQY-w0KCUVZNO_LyhRNjNzZ86dxX0Gs-7cGQDeMFpSjvlH2w5q6XtLQjB6AHPMGHE8TOlsnKnrOYS59Ak8D0OLkI85QnPwJWAoSgnzFdwknzKCcZ6JSKQw2pWxzGSZlFCEYRLJrBJpuoORrGRYjWC0LZIshlUhRbUZr3CVF3DcbJNstK9lkSXiBTxadRrM660vwHYlq3DtpHmchCJ1NOYechqOmaYY77WrG58TFigbNJrsrUaGauQTRgLPWGWJYaNWgasspb7LSYOtR-gCvF__6v48DL2x9W9__FH9X41RPUVTT9HUvldP0Yz46oq3w0UdzB1W_eWoT6buj93BYM7Z5LiVyXgH9Lfqa9PRf7K2adU
ContentType Journal Article
Copyright Japan Surgical Association
Copyright_xml – notice: Japan Surgical Association
DBID AAYXX
CITATION
DOI 10.3919/jjsa.65.2210
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
EISSN 1882-5133
EndPage 2215
ExternalDocumentID 10_3919_jjsa_65_2210
article_ringe1998_65_8_65_8_2210_article_char_en
GroupedDBID ALMA_UNASSIGNED_HOLDINGS
CS3
JSF
KQ8
RJT
123
2WC
AAYXX
CITATION
ID FETCH-LOGICAL-c1950-d918c311bc4cd69287af7dc2bfc0e3c0628275efaf2e83c0a74af336492d1f523
ISSN 1345-2843
IngestDate Tue Jul 01 03:24:14 EDT 2025
Wed Sep 03 06:28:54 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Issue 8
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c1950-d918c311bc4cd69287af7dc2bfc0e3c0628275efaf2e83c0a74af336492d1f523
OpenAccessLink https://www.jstage.jst.go.jp/article/ringe1998/65/8/65_8_2210/_article/-char/en
PageCount 6
ParticipantIDs crossref_primary_10_3919_jjsa_65_2210
jstage_primary_article_ringe1998_65_8_65_8_2210_article_char_en
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2004
PublicationDateYYYYMMDD 2004-01-01
PublicationDate_xml – year: 2004
  text: 2004
PublicationDecade 2000
PublicationTitle Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
PublicationTitleAlternate Nihon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc)
PublicationYear 2004
Publisher Japan Surgical Association
Publisher_xml – name: Japan Surgical Association
References 10) Sohval AR: “Mixed” gonadal dysgenesis: A variety of hermoaphroditism. Am J Hum Genet 15: 155-158, 1962
5) Siiteri PK, Wilson JD: Testosterone formation and metabolism during male sexual differentiation in the human embryo. J Clin Endocrinol Metab 38: 113-125, 1974
8) 梅原次男,熊本悦明,丸田 浩 他:尿道下裂及び男性半陰陽におけるvaginal rest (残存膣)の形態学的検討.日泌会誌 76: 635-644, 1985
4) Berta P, Hawkins JR, Sinclair AH, et al: Genetic evidence equating SRY and the testis-determining factor. Nature 348: 448-450, 1990
3) 岩動孝一郎:男性仮性半陰陽.日泌会誌 85: 1189-1212, 1994
11) Mendez JP, Ulloa-Aguirre A, Kofman-Alfaro S, et al: Mixed gonadal dysgenesis: Clinical, cytogenetic, endocrinolo gical, and histopathological findings in 16patients. Amer J Med Genet 46: 263-267, 1993
7) 榊原尚行,野々村克也,小柳知彦 他:尿道下裂の臨床的,内分泌学的検討.日泌会誌 76: 716-722, 1985
13) 鞁嶋有紀,花木啓一,澤田宏志 他: Y染色体成分を含んだ性腺形成不全の2例.小児臨 53: 1623-1626, 2000
2) 島 博基,生駒文彦: Müller管退縮物質について.日泌会誌 84: 1747-1758, 1993
14) 島本良子,大隅 昇,石川 正:仮性半陰陽2例に対する治療経験.形成外科 42: 39-49, 1999
6) 小柳知彦,野々村克也:尿道下裂.日泌会誌 81: 1609-1617, 1990
1) 藤本昌敏:卒後教育シリーズ 第4回 性分化異常の診断と治療.小児診療 50: 164-171, 1987
9) 福谷恵子:男性仮性半陰陽.日臨 55: 120-124, 1997
12) 服部重人,高橋洋子,三宅 浩他: 45, X/46, XY性腺形成不全症の3例.ホルモンと臨 48: 1033-1037, 2000
References_xml – reference: 8) 梅原次男,熊本悦明,丸田 浩 他:尿道下裂及び男性半陰陽におけるvaginal rest (残存膣)の形態学的検討.日泌会誌 76: 635-644, 1985
– reference: 3) 岩動孝一郎:男性仮性半陰陽.日泌会誌 85: 1189-1212, 1994
– reference: 9) 福谷恵子:男性仮性半陰陽.日臨 55: 120-124, 1997
– reference: 5) Siiteri PK, Wilson JD: Testosterone formation and metabolism during male sexual differentiation in the human embryo. J Clin Endocrinol Metab 38: 113-125, 1974
– reference: 6) 小柳知彦,野々村克也:尿道下裂.日泌会誌 81: 1609-1617, 1990
– reference: 1) 藤本昌敏:卒後教育シリーズ 第4回 性分化異常の診断と治療.小児診療 50: 164-171, 1987
– reference: 11) Mendez JP, Ulloa-Aguirre A, Kofman-Alfaro S, et al: Mixed gonadal dysgenesis: Clinical, cytogenetic, endocrinolo gical, and histopathological findings in 16patients. Amer J Med Genet 46: 263-267, 1993
– reference: 12) 服部重人,高橋洋子,三宅 浩他: 45, X/46, XY性腺形成不全症の3例.ホルモンと臨 48: 1033-1037, 2000
– reference: 10) Sohval AR: “Mixed” gonadal dysgenesis: A variety of hermoaphroditism. Am J Hum Genet 15: 155-158, 1962
– reference: 14) 島本良子,大隅 昇,石川 正:仮性半陰陽2例に対する治療経験.形成外科 42: 39-49, 1999
– reference: 2) 島 博基,生駒文彦: Müller管退縮物質について.日泌会誌 84: 1747-1758, 1993
– reference: 7) 榊原尚行,野々村克也,小柳知彦 他:尿道下裂の臨床的,内分泌学的検討.日泌会誌 76: 716-722, 1985
– reference: 13) 鞁嶋有紀,花木啓一,澤田宏志 他: Y染色体成分を含んだ性腺形成不全の2例.小児臨 53: 1623-1626, 2000
– reference: 4) Berta P, Hawkins JR, Sinclair AH, et al: Genetic evidence equating SRY and the testis-determining factor. Nature 348: 448-450, 1990
SSID ssj0061900
ssib002484630
ssib002484631
Score 1.5339631
Snippet Mixed gonadal dysgenesis has a chromosomal aberration mainly due to 45X/46XY chromosomal mosaic, so the lateral gonad may be a testis and the contralateral a...
SourceID crossref
jstage
SourceType Index Database
Publisher
StartPage 2210
Title A CASE OF MIXED GONADAL DYSGENESIS ACCIDENTALLY DETECTED DURING TREATMENT FOR INGUINAL HERNIA
URI https://www.jstage.jst.go.jp/article/ringe1998/65/8/65_8_2210/_article/-char/en
Volume 65
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 2004/08/25, Vol.65(8), pp.2210-2215
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELaWhQMXBALE8pIP9BSlNO_khKwk24aWVLSp1B5Q5DiJ-pC6iG0P7M_gFzMTJ2lAPSxcrNrxo818Hc9Y34wJ-ZBZ7qDUDEvVNVuopumUKuhAW7UL7rluVsCWVmX7jO3Rwvy8tJYXF786rKXjIeuLu7NxJf8jVWgDuWKU7D9Itp0UGuAzyBdKkDCU95IxU3w2D5G48yVahoEynMYsYBMlWM2RkjaP5grz_SgI44RNJislCJPQB1WlBAskQSjJLGQJZvNXwBdUoGURIRFoFM7iiHXN1nizBpTMNvvbdc-3ei4sVey4MuS7Hd8od2CArzet_gBNPR0zGbV_YtZGKzZk46jCB98df7bbwThK2LTaCW5glgPfnZ6wYJqwOJIPN6JeozmjMDsK1TABB65MxdQvZBta9XivTFcLyxsjarS5XZWq17zXoqla51S_4WmYOXW7veV92-qfRnUzbP-187V8RPCEcHyKo1PbSnH0A_JQdxwNaaLjr10XDSy2jssl6y2tCPzRgYxMr3-3DLbA2T92v9sfZtCjLXgCDYuwMmySp-RJ7ZFQJuH1jFwU--fkG6MILTq9phW0aA0teoIW7UKLNtCiElq0hRYFaNEGWlRC6wVZXIeJP1LrmzhUgdcEq7mnucLQtEyYIrc98LJ56eRCz0oxKAyBcbi6YxUlL_XChTp3TF4ahm16eq6Vlm68JJf7m33xitBM4MGZq2GKbLMEZ9zNwekQusgNkRUevyK95sWk32XClfSceK7IJ_nW2l713zCtzsMxdBS71gWOaDtgPCOoj9f3XOkNeSzpWnju9pZcHn4ci3dgiR6y9xU0fgNLeHNb
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+CASE+OF+MIXED+GONADAL+DYSGENESIS+ACCIDENTALLY+DETECTED+DURING+TREATMENT+FOR+INGUINAL+HERNIA&rft.jtitle=Nihon+Rinsh%C5%8D+Geka+Gakkai+zasshi&rft.au=YASUOKA%2C+Rie&rft.au=MIYAGAKI%2C+Takuya&rft.au=KITAO%2C+Yoshitaka&rft.au=KADOTANI%2C+Yoichi&rft.date=2004&rft.issn=1345-2843&rft.eissn=1882-5133&rft.volume=65&rft.issue=8&rft.spage=2210&rft.epage=2215&rft_id=info:doi/10.3919%2Fjjsa.65.2210&rft.externalDBID=n%2Fa&rft.externalDocID=10_3919_jjsa_65_2210
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1345-2843&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1345-2843&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1345-2843&client=summon