New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses

• Published in: Mendeleev communications Vol. 35; no. 2; pp. 145 - 147
• Main Authors: Zhupikova, Olga A., Yarovaya, Olga Ivanovna, Marenina, Mariya K., Meshkova, Yulia V., Belenkaya, Svetlana V., Shcherbakov, Dmitriy N., Zaykovskaya, Anna V., Pyankov, Oleg V., Zarubaev, Vladimir V., Mikhalsky, Mikhail G., Fedorov, Alexey Yu, Arkhipov, Sergey G., Potkin, Vladimir Ivanovich, Kolesnik, Irina A., Ivanov, Andrey Viktorovich, Salakhutdinov, Nariman Faridovich, Khvostov, Mikhail V.
• Format: Journal Article
• Language: English; Russian
• Published: 01.03.2025

New thiosemicarbazones based on 5-arylisoxazole-3-carbaldehyde and substituted pyrrolecarbaldehydes have been obtained. The test for ability to inhibit the main viral protease 3Clpro of SARS-CoV-2 virus revealed a compound with activity against both corona- and influenza viruses.