New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses

New thiosemicarbazones based on 5-arylisoxazole-3-carbaldehyde and substituted pyrrolecarbaldehydes have been obtained. The test for ability to inhibit the main viral protease 3Clpro of SARS-CoV-2 virus revealed a compound with activity against both corona- and influenza viruses.

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Bibliographic Details
Published inMendeleev communications Vol. 35; no. 2; pp. 145 - 147
Main Authors Zhupikova, Olga A., Yarovaya, Olga Ivanovna, Marenina, Mariya K., Meshkova, Yulia V., Belenkaya, Svetlana V., Shcherbakov, Dmitriy N., Zaykovskaya, Anna V., Pyankov, Oleg V., Zarubaev, Vladimir V., Mikhalsky, Mikhail G., Fedorov, Alexey Yu, Arkhipov, Sergey G., Potkin, Vladimir Ivanovich, Kolesnik, Irina A., Ivanov, Andrey Viktorovich, Salakhutdinov, Nariman Faridovich, Khvostov, Mikhail V.
Format Journal Article
LanguageEnglish
Russian
Published 01.03.2025
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Summary:New thiosemicarbazones based on 5-arylisoxazole-3-carbaldehyde and substituted pyrrolecarbaldehydes have been obtained. The test for ability to inhibit the main viral protease 3Clpro of SARS-CoV-2 virus revealed a compound with activity against both corona- and influenza viruses.
ISSN:0959-9436
1364-551X
DOI:10.71267/mencom.7578