Clinicopathological studies of oral lichen planus improving after removal of intraoral dental metals
A relation between oral lichen planus (OLP) and oral prosthetic metals has been reported because OLP may improve after their removal. However, the criteria for evaluating their involvement in the clinical and histopathological signs of OLP have not been established. We compared the clinical and hist...
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| Published in | Japanese Journal of Oral and Maxillofacial Surgery Vol. 45; no. 7; pp. 445 - 452 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japanese Society of Oral and Maxillofacial Surgeons
1999
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.45.445 |
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| Abstract | A relation between oral lichen planus (OLP) and oral prosthetic metals has been reported because OLP may improve after their removal. However, the criteria for evaluating their involvement in the clinical and histopathological signs of OLP have not been established. We compared the clinical and histological features of 18 cases of OLP that improved after removal of dental metals with those of 18 cases that did not improve clinically after removal. All patients were positive to dental metals on patch testing and had OLP refractory to conventional therapy. Improved cases of OLP were characterized by unilateral involvement of the buccal mucosa, showing a reticular pattern with the formation of erosions and ulcers. Histologically, most cases had remarkable humoral degeneration of the basal cell layer, lymphocytic invasion of the lamina propria, and spongiosis. |
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| AbstractList | A relation between oral lichen planus (OLP) and oral prosthetic metals has been reported because OLP may improve after their removal. However, the criteria for evaluating their involvement in the clinical and histopathological signs of OLP have not been established. We compared the clinical and histological features of 18 cases of OLP that improved after removal of dental metals with those of 18 cases that did not improve clinically after removal. All patients were positive to dental metals on patch testing and had OLP refractory to conventional therapy. Improved cases of OLP were characterized by unilateral involvement of the buccal mucosa, showing a reticular pattern with the formation of erosions and ulcers. Histologically, most cases had remarkable humoral degeneration of the basal cell layer, lymphocytic invasion of the lamina propria, and spongiosis. |
| Author | FUKUNAGA, Syuichi HAYASHI, Emiko TATSUTA, Tsuneyasu SHIMADA, Jun YAMAMOTO, Yoshiro MORI, Kazumasa TAKESHIMA, Hiroshi KIKUCHI, Kentaro YAMAZAKI, Yasuyuki NAKANISHI, Tohru NAMIKI, Ichiro |
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| References | 11) James, J.: Orallichenoid reactions related to mercury sensitivit.: Br J Oral Maxillofac surg 25: 474-480 1987. 21) 浅田光一, 山本英雄, 他: 口腔扁平苔癬の臨床病態の検討. 日口外誌 39: 462-468 1993. 27) 中山秀夫, 禾紀子, 他: アレルギーと歯の金属. 日歯医師会誌40: 893-903 1987. 31) 石川梧朗: 口腔病理学II, 改訂版, 永末書店, 京都, 1982,215-219頁. 4) Lind, P.O., Hurlen, B., et al.: Amalgamrelated oral lichenoid reaction. Scand J Dent Res 94: 448-451 1986. 33) 鈴木真理, 荻野泰子, 他: パッチテスト反応の組織所見のまとめ. 皮膚31, 増刊号: 241-250 1989. 15) 池村邦男: 口腔粘膜の扁平苔癬に関する臨床的ならびに病理学的研究. 口科誌 21: 555-581 1972. 2) 山本美朗, 永峰浩一郎, 他: 口腔の愁訴と金属アレルギー. 東京都歯科医師会雑誌 44: 675-681 1997. 20) 藤本和久, 玉城広保: 口腔粘膜扁平苔癬32例の臨床的検討. 医療 46: 252-257 1992. 25) 禾紀子: 金属アレルギー患者における口腔内電流測定による歯科金属溶出傾向の検討. 日皮会誌 99: 1243-1254 1989. 7) 本多章乃, 宮川かおり, 他: 金属義歯床による口唇, 口腔粘膜の扁平苔癬. 皮膚臨床 34: 199-202 1992. 12) Skoglund, A.: Hypersensitivity reaction to dental materials in patients withlichenoid oral mucosal lesions and in patients with burning mouth syndrome.: Scand J Dent Res 99: 320-328 1991. 16) Eisenberg, E.: Clinicopathological patterns of oral lichenoid lesions. Oral and Maxillofacial Surgery Clinics of North America 1994, p455-463. 13) 井上昌幸, 中山秀夫: 歯科と金属アレルギー. デンタルダイヤモンド社, 東京, 1994, 54-61頁. 32) 菅原由美子, 古内寿, 他: 口腔粘膜疾患の臨床病態と粘膜表面微細構造に関する診断学的研究第2報扁平苔癬. 日口診誌 4: 108-115 1991. 1) 中山秀夫, 大城晶子, 他: 歯科金属のアレルギーによると思われる扁平苔癬の2例について. 耳喉 44: 239-247 1972. 5) 金友仁成, 濱田稔夫, 他: 歯科金属 (金) によると考えられた口腔内扁平苔癬の1例. 皮膚34 (増刊号14): 271-274 1992. 24) Shklar, G. McCarthy, P.L.: The oral lesions of lichen planus. Observations on 100 cases. Oral Surg 14: 164 1961. 17) 橋本和明: 口腔粘膜の扁平紅色苔癬に関する研究. 口科誌 18: 660-685 1969. 30) Lever, W. F., Schaumburg-Lever, G.: Histopathology of the Skin, ed. 5, J.B. Lippencott, Philadelphia, 1975, P147-149. 34) Medenica, M., Rostenberg, A.: A comparative light and electron microscopic study of primary irritant contact dermatitis and allergic contact dermatitis, J. Invest. Dermatol., 56: 259-271 1971. 28) 栗原誠一: 金属による扁平苔癬. 医薬の門 35: 51-53 1995. 10) 林原利朗, 大山勝郎, 他: 歯科用コバルトによる口腔粘膜扁平苔癬. 臨床皮膚 36: 481-485 1982. 22) 岩田政裕, 西嶋寛, 他: 口腔扁平苔癬の臨床的検討. 日口粘膜誌 2: 95-101 1996. 19) 小川裕三, 足立寛, 他: 口腔粘膜の扁平苔癬65例の臨床病理学的検討. 口科誌 33: 1-8 1984. 23) Andreasen, J. O.: Oral lichen planus. I, A clinical evaluation of 115 cases. Oral Surg 25: 31 1968. 6) 禾紀子, 中山秀夫: 歯科用パラジュウム合金によると思われる扁平苔癬の1例. 臨皮 43: 269-273 1989. 14) 井上昌幸, 中山秀夫: 歯科と金属アレルギー. デンタルダイヤモンド社, 東京, 1994, 86-97頁. 8) 藤好ふみ子, 中村尚, 他: 歯科用金属が誘因と思われる扁平苔癬の1例. 逓信医学 45: 817-819 1993. 18) 井ノ上俊郎, 杉原一正, 他: 口腔扁平苔癬の臨床統計的観察. 日口外誌 28: 1571-1576 1982. 26) 中山秀夫, 村田真道, 他: 歯科金属による感作の可能性について. 歯界展望 43: 382-389 1974. 9) Wood, J.F.: Mucosal reaction to cobaltchromium alloy.: Br Dent J 136: 423-4241974. 35) Lachapelle, J. M.: Comparative histopathology of allergic and irritant reactions in man. Arch. Belg. Dermatol. 28: 83-92 1973. 3) Kaj, Finne., Kerstin, Goransson. et al.: Oral lichen planus and contact allergy to mercury. Int J Oral Surg 11: 236-239 1982. 29) 栗原誠一: 金属アレルギーによる皮膚粘膜疾患. 歯科と金属アレルギー 38-53 1993. |
| References_xml | – reference: 4) Lind, P.O., Hurlen, B., et al.: Amalgamrelated oral lichenoid reaction. Scand J Dent Res 94: 448-451 1986. – reference: 16) Eisenberg, E.: Clinicopathological patterns of oral lichenoid lesions. Oral and Maxillofacial Surgery Clinics of North America 1994, p455-463. – reference: 20) 藤本和久, 玉城広保: 口腔粘膜扁平苔癬32例の臨床的検討. 医療 46: 252-257 1992. – reference: 3) Kaj, Finne., Kerstin, Goransson. et al.: Oral lichen planus and contact allergy to mercury. Int J Oral Surg 11: 236-239 1982. – reference: 7) 本多章乃, 宮川かおり, 他: 金属義歯床による口唇, 口腔粘膜の扁平苔癬. 皮膚臨床 34: 199-202 1992. – reference: 2) 山本美朗, 永峰浩一郎, 他: 口腔の愁訴と金属アレルギー. 東京都歯科医師会雑誌 44: 675-681 1997. – reference: 26) 中山秀夫, 村田真道, 他: 歯科金属による感作の可能性について. 歯界展望 43: 382-389 1974. – reference: 23) Andreasen, J. O.: Oral lichen planus. I, A clinical evaluation of 115 cases. Oral Surg 25: 31 1968. – reference: 9) Wood, J.F.: Mucosal reaction to cobaltchromium alloy.: Br Dent J 136: 423-4241974. – reference: 14) 井上昌幸, 中山秀夫: 歯科と金属アレルギー. デンタルダイヤモンド社, 東京, 1994, 86-97頁. – reference: 30) Lever, W. F., Schaumburg-Lever, G.: Histopathology of the Skin, ed. 5, J.B. Lippencott, Philadelphia, 1975, P147-149. – reference: 28) 栗原誠一: 金属による扁平苔癬. 医薬の門 35: 51-53 1995. – reference: 13) 井上昌幸, 中山秀夫: 歯科と金属アレルギー. デンタルダイヤモンド社, 東京, 1994, 54-61頁. – reference: 19) 小川裕三, 足立寛, 他: 口腔粘膜の扁平苔癬65例の臨床病理学的検討. 口科誌 33: 1-8 1984. – reference: 24) Shklar, G. McCarthy, P.L.: The oral lesions of lichen planus. Observations on 100 cases. Oral Surg 14: 164 1961. – reference: 33) 鈴木真理, 荻野泰子, 他: パッチテスト反応の組織所見のまとめ. 皮膚31, 増刊号: 241-250 1989. – reference: 5) 金友仁成, 濱田稔夫, 他: 歯科金属 (金) によると考えられた口腔内扁平苔癬の1例. 皮膚34 (増刊号14): 271-274 1992. – reference: 21) 浅田光一, 山本英雄, 他: 口腔扁平苔癬の臨床病態の検討. 日口外誌 39: 462-468 1993. – reference: 15) 池村邦男: 口腔粘膜の扁平苔癬に関する臨床的ならびに病理学的研究. 口科誌 21: 555-581 1972. – reference: 6) 禾紀子, 中山秀夫: 歯科用パラジュウム合金によると思われる扁平苔癬の1例. 臨皮 43: 269-273 1989. – reference: 25) 禾紀子: 金属アレルギー患者における口腔内電流測定による歯科金属溶出傾向の検討. 日皮会誌 99: 1243-1254 1989. – reference: 29) 栗原誠一: 金属アレルギーによる皮膚粘膜疾患. 歯科と金属アレルギー 38-53 1993. – reference: 31) 石川梧朗: 口腔病理学II, 改訂版, 永末書店, 京都, 1982,215-219頁. – reference: 18) 井ノ上俊郎, 杉原一正, 他: 口腔扁平苔癬の臨床統計的観察. 日口外誌 28: 1571-1576 1982. – reference: 27) 中山秀夫, 禾紀子, 他: アレルギーと歯の金属. 日歯医師会誌40: 893-903 1987. – reference: 17) 橋本和明: 口腔粘膜の扁平紅色苔癬に関する研究. 口科誌 18: 660-685 1969. – reference: 34) Medenica, M., Rostenberg, A.: A comparative light and electron microscopic study of primary irritant contact dermatitis and allergic contact dermatitis, J. Invest. Dermatol., 56: 259-271 1971. – reference: 11) James, J.: Orallichenoid reactions related to mercury sensitivit.: Br J Oral Maxillofac surg 25: 474-480 1987. – reference: 35) Lachapelle, J. M.: Comparative histopathology of allergic and irritant reactions in man. Arch. Belg. Dermatol. 28: 83-92 1973. – reference: 22) 岩田政裕, 西嶋寛, 他: 口腔扁平苔癬の臨床的検討. 日口粘膜誌 2: 95-101 1996. – reference: 8) 藤好ふみ子, 中村尚, 他: 歯科用金属が誘因と思われる扁平苔癬の1例. 逓信医学 45: 817-819 1993. – reference: 1) 中山秀夫, 大城晶子, 他: 歯科金属のアレルギーによると思われる扁平苔癬の2例について. 耳喉 44: 239-247 1972. – reference: 32) 菅原由美子, 古内寿, 他: 口腔粘膜疾患の臨床病態と粘膜表面微細構造に関する診断学的研究第2報扁平苔癬. 日口診誌 4: 108-115 1991. – reference: 10) 林原利朗, 大山勝郎, 他: 歯科用コバルトによる口腔粘膜扁平苔癬. 臨床皮膚 36: 481-485 1982. – reference: 12) Skoglund, A.: Hypersensitivity reaction to dental materials in patients withlichenoid oral mucosal lesions and in patients with burning mouth syndrome.: Scand J Dent Res 99: 320-328 1991. |
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| Title | Clinicopathological studies of oral lichen planus improving after removal of intraoral dental metals |
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