Caracterización epidemiológica e histopatológica de metástasis cutáneas en la población consultante de 2 hospitales de Santiago durante los años 2005 a 2017
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| Published in | Actas dermo-sifiliográficas Vol. 110; no. 3; pp. 220 - 226 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Spanish |
| Published |
Elsevier España, S.L.U
01.04.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Graphical abstract |
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Las metástasis cutáneas (MC) constituyen el 2% de los tumores cutáneos, y su incidencia varía entre el 0,7% y el 9% de los pacientes con cáncer. El objetivo de este estudio es describir y analizar las características demográficas, clínicas e histopatológicas de las MC en población consultante de 2 hospitales de la Región Metropolitana.
Estudio retrospectivo, descriptivo, analítico, observacional y transversal. Se revisaron los informes histopatológicos, fichas, láminas histopatológicas y fechas de defunción de los casos con diagnóstico de MC del servicio de anatomía patológica de 2 hospitales de la Región Metropolitana entre los años 2005 y 2017.
Se incluyeron 96 casos de MC. El 60,42% fueron mujeres y el 39,58% hombres. La edad promedio al momento del diagnóstico fue de 67,95±13,74 años, con un rango de 28 a 96 años. La fuente neoplásica primaria más frecuente fue melanoma en el 27,08% (n=26), seguido de carcinoma de mama 18,75% (n=18) y adenocarcinoma 15,63% (n=15). La mediana de tiempo entre el diagnóstico del tumor y la metástasis cutánea fue de 9 meses. Los pacientes con MC de melanoma presentaron una mayor sobrevida que aquellos con metástasis de otro origen (p<0,05). El examen histopatológico de 91 láminas mostró con mayor frecuencia una infiltración difusa del tejido con células tumorales y con baja frecuencia la presencia de permeación vascular.
Los resultados obtenidos se asemejan a la realidad internacional. Las MC son poco frecuentes, constituyendo una rara manifestación de neoplasias internas, se presentan principalmente a edades avanzadas y en ambos sexos por igual.
Cutaneous metastases (CMs) account for 2% of skin tumors and their incidence varies between 0.7% and 9% in patients with cancer. The objective of this study was to describe and analyze the demographic, clinical, and histopathologic characteristics of CM in patients who visited 2 hospitals in the Santiago de Chile metropolitan region.
We performed a retrospective, descriptive, analytical, observational, cross-sectional study. We reviewed the pathology reports, patient records, pathology slides, and dates of death for diagnosed cases of CM from the anatomic pathology departments of 2 hospitals in the Santiago de Chile metropolitan region between 2015 and 2017.
Ninety-six patients with CM were included in the study; 60.42% were women and 39.58% were men. The mean (SD) age was 67.95 (13.74) years, with a range of 28 to 96 years. The most common primary tumor was melanoma in 27.08% of cases (n=26), followed by breast cancer (18.75%, n=18), and adenocarcinoma (15.63%, n=15). The median time between diagnosis of the tumor and cutaneous metastasis was 9 months. Patients with CM of melanoma had a higher survival rate than patients with metastasis of other primary tumors (P<.05). A histopathologic study of 91 slides showed that diffuse infiltration of the tissue with tumor cells was the most common pattern and vascular invasion was rare.
The results are similar to those found worldwide. CM is a rare manifestation of internal tumors. It presents mainly at an advanced age and is equally prevalent in both sexes. Graphical abstract |
| Author | Vera, V Morales, C Sanhueza, I Segovia, L Bobadilla, F Kaplan, V Fernández, J |
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| DocumentTitleAlternate | Epidemiologic and Histopathologic Characterization of Cutaneous Metastases in Patients Who Visited 2 Hospitals in Santiago de Chile Between 2005 and 2017 |
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| Keywords | Epidemiología Clínica Histopathology Histopatología Clinical Cutaneous metastasis Metástasis cutánea Sobrevida Epidemiology Survival |
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| Snippet | Graphical abstract [Display omitted] Las metástasis cutáneas (MC) constituyen el 2% de los tumores cutáneos, y su incidencia varía entre el 0,7% y el 9% de los pacientes con... |
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| SubjectTerms | Clinical Clínica Cutaneous metastasis Dermatology Epidemiology Epidemiología Histopathology Histopatología Metástasis cutánea Sobrevida Survival |
| Title | Caracterización epidemiológica e histopatológica de metástasis cutáneas en la población consultante de 2 hospitales de Santiago durante los años 2005 a 2017 |
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