Influence of oipA Phase Variation on Virulence Phenotypes Related to Type IV Secretion System in Helicobacter pylori

• Published in: Helicobacter (Cambridge, Mass.) Vol. 29; no. 5; pp. e13140 - n/a
• Main Authors: Lai, Jing, Angulmaduwa, Sacheera, Kim, Myeong‐A, Kim, Aeryun, Tissera, Kavinda, Cho, Yong‐Joon, Cha, Jeong‐Heon
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2024
• Subjects: Antigens, Bacterial - genetics; Antigens, Bacterial - metabolism; Bacteria; Bacterial Outer Membrane Proteins - genetics; Bacterial Outer Membrane Proteins - metabolism; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Cell morphology; Complementation; Elongation; Gastric cancer; Gene sequencing; Genetic diversity; H. pylori; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - pathogenicity; Helicobacter pylori - physiology; Humans; In vitro methods and tests; Interleukin-8 - genetics; Interleukin-8 - metabolism; Molecular modelling; oipA; OipA gene; Outer membrane proteins; Pathogenicity; Pathogens; phase variation; Phase variations; Phenotype; Phenotypes; Phenotypic variations; Phosphorylation; T4SS; Type IV Secretion Systems - genetics; Type IV Secretion Systems - metabolism; Virulence; Virulence - genetics; Virulence Factors - genetics; Virulence Factors - metabolism; Whole genome sequencing; H. pylori; T4SS; oipA; phase variation

ABSTRACT Background oipA, an outer membrane protein of Helicobacter pylori, is linked to IL‐8 induction and gastric inflammation, but its role is debated due to inconsistent findings. This study aims to explore the role of oipA phase variation in modulating the virulence traits of H. pylori, a bacte...