Experimental study on the effect of long-term ethanol intake on the rat parotid glands
To elucidate the effect of long-term intake of ethanol on the parotid gland, observations of parotid glands from male Wistar Strain rats given 20% ethanol ad lib. instead of water were performed, using light and electron microscopy. Results were as follows:(1) Under the light microscope, 3 rats (11%...
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| Published in | Japanese Journal of Oral and Maxillofacial Surgery Vol. 35; no. 4; pp. 820 - 835 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Japanese Society of Oral and Maxillofacial Surgeons
1989
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| Subjects | |
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| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.35.820 |
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| Abstract | To elucidate the effect of long-term intake of ethanol on the parotid gland, observations of parotid glands from male Wistar Strain rats given 20% ethanol ad lib. instead of water were performed, using light and electron microscopy. Results were as follows:(1) Under the light microscope, 3 rats (11%) demonstrated several lesions involving complete lobular units, and (2) under the electron microscope, the earliest and most consistent changes after ethanol intake were the irregular formation of microvilli and interdigitation between parenchymal cells. These were accompanied by widening of the intercellular spaces and disappearance of the basal infolding structure with severe mitochondrial alteration in striated duct cells. Tortous proliferation of intercalated duct cells was observed after 4 months of ethanol intake. These results suggest that the intake of ethanol leads to injury of the inter-parenchymal cell membranes and to the basal membranes of striated duct cells. Repeated degeneration and regeneration of duct cells during the repair process results in deformation of ductal structure at the level of the intercalated ducts, followed by the degeneration and subsequent atrophy of the acini. |
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| AbstractList | To elucidate the effect of long-term intake of ethanol on the parotid gland, observations of parotid glands from male Wistar Strain rats given 20% ethanol ad lib. instead of water were performed, using light and electron microscopy. Results were as follows:(1) Under the light microscope, 3 rats (11%) demonstrated several lesions involving complete lobular units, and (2) under the electron microscope, the earliest and most consistent changes after ethanol intake were the irregular formation of microvilli and interdigitation between parenchymal cells. These were accompanied by widening of the intercellular spaces and disappearance of the basal infolding structure with severe mitochondrial alteration in striated duct cells. Tortous proliferation of intercalated duct cells was observed after 4 months of ethanol intake. These results suggest that the intake of ethanol leads to injury of the inter-parenchymal cell membranes and to the basal membranes of striated duct cells. Repeated degeneration and regeneration of duct cells during the repair process results in deformation of ductal structure at the level of the intercalated ducts, followed by the degeneration and subsequent atrophy of the acini. |
| Author | MATSUO, Masaatsu |
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| References | 33) Sharawy, M., Schuster, G., etal. Association of mitochondria with the plasma mem. brane of the acinar cells of thc mouse submaxillary glands. Actaanat 102: 440-446 1978. 23) Minaire, Y., Descos, L., et al. Chronic pancreatitis, alcoholic liver cirrhosis and salivary secretion. Digestion 12: 57-60 1975. 37) Noronha, M., Dreiling, D. A., et al.: The parotid and pancreas. IV Parotid secretion after secretin stimulation as a screening test of pancreatic dysfunction. Am J Gastroenterol 70: 282-285 1978. 28) Kakizaki, G., Sasahara, M., eta L: Onthe pathogenesis of chronic alcoholic pancreatitis from the viewpoint of experimental results in rats. Int J Pancreatol 2: 101-116 1987. 1) Borsanyi, S. J. and Blanchard, C.: Asymptomatic enlargement of the parotid gland in alcoholic cirrhosis. South Med J 54: 678-682 1961. 43) Baratti, C. M., Rubio, M. C., et al.: Effect of chronic alcohol feeding on adrenergic and cholinergic neurotransmission mechanism. Am J Gastroenterol 73: 21-27 1980. 41) Kakizaki, G., Sasahara, M., et al. Mechanism of the pancreas-parotid gland interaction. Am J Gastroenterol 70: 635-644 1978. 35) Schneyer, L., Young, I. A., et al.: Salivary secretion of electrolytes. Physiol Rev 52: 720-777 1972. 18) Sarles, H., Lebreuil, G., et al.: A comparison of alcoholic pancreatitis in rat and man. Gut 12: 377-388 1971. 20) Luft, J. H.: Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol 9: 409-414 1961. 5) Borsanyi, S. J.: Chronic asymptomatic enlargement of the parotid glands. Ann Otol Rhinol Laryngol 71: 857-867 1962. 13) Russotto, S. B. Asymptomatic parotid gland enlargement in diabetes mellitus. Oral Surg 52: 594-598 1981. 46) Rubin, E. and Rottenberg, H.: Ethanolinduced injury and adaptation in biological membranes. Federation Proceedings 41: 2465-2471 1982. 48) Nakamura, T., Nakayama, Y., et al.: Reci-procal modulation of growth and liver functions of mature rat hepatocytes in primary culture by an extract of hepatic plasma membranes. J Biol Chem 259: 8056-8058 1984. 3) Hemenway, W. G. and Allen, G. W.: Chronic enlargement of the parotid gland: Hypertrophy and fatty infiltration. Laryngoscope 69: 1508-1522 1959. 31) Pinkstaff, C. A.: The cytology of salivary glands. Int Rev Cyto1 63: 141-261 1980. 27) 池田浩之, 今野陽三, 他: アルコール依存症における耳下腺病変. 内科56: 163-167 1985. 9) Katsilambros, L.: Asymptomatic enlargement of the parotid glands. JAMA 178: 513-514 1961. 6) Wolfe, S. J., Summerskill, W. H. J., et al.: Parotid swelling, alcoholism and cirrhosis. N Engl J Med 256: 491-495 1957. 24) Grimmel, K., Rossbach, G., et al.: Amylase activity of parotid saliva in acute and chronic pancreatitis. Acta Hepato-Gastroenterol 23: 334-344 1976. 7) Mandel, L. and Baurmash, H.: Parotid enlargement due to alcoholism. JADA 82: 369-373 1971. 47) Nakamura, T., Yoshimoto, K., et al.: Reciprocal modulation of growth and differentiated functions of mature rat hepatocytes in primary culture by cell-cell contact and cell membranes. Proc Natl Acad Sci USA 80: 7229-7233 1983. 14) Seifert, G.: Zur Pathogenese der Speicheldrüsenschwellung (Sialadenose). Verh Dtsch Ges Pathol 46: 250-256 1962. 44) Friedemann, T. E., Motel, W. G., et al.: The excretion of ingested ethyl alcohol in saliva J Lab Clin Med 23: 1007-1013 1938. 42) Perec, C. J., Celener, D., et al. Effects of chronic ethanol administration on the autonomic innervation of salivary glands, pancreas and heart. Am J Gastroenterol 72: 46-59 1979. 21) 峯川宏一: アルコール性肝障害時における顎下腺の変化. 日大医誌43: 459-473 1984. 38) Kakizaki, G., Noto, N., et al.: Histologic findings of the parotid gland and bicarbonate content in parotid saliva of dogs with experimentally produced pancreatitis. Tohoku J Exp Med 108: 165-177 1972. 4) Kaltreider, H. B. and Talal, N.: Bilateral parotid gland enlargement and hyperlipoproteinemia. JAMA 210: 2067-2070 1969. 32) Smith, P. H. and Petel, D. G. Immunochemical studies of the insulin-like material in the parotid gland of rats. diabetes 33: 661-666 1984. 40) Ludwig, H., Schernthaner, G., et al.: Antibodies to pancreatic duct cells in Sjögren's syndrome and rheumatoid arthritis. Gut 18: 311-315 1977. 30) Sarles, H., Muratore, R., etal. Aetiology and pathology of chronic pancreatitis. Bib I Gastroenterol 7: 75-120 1965. 16) Rubin, E. and Lieber, C. S. Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates. N Engl J Med 290: 128-135 1974. 34) Katsuyama, T. and Spicer, S. S.: The surface characteristics of the plasma membrane of the exocrine pancreas. Am JAnat 148: 535-554 1977. 36) Cantin, M., Gutkowska, J., et al. Immunocytochemical localization of atrial natriuretic factor in the heart and salivary glands. Histochemistry 80: 80: 113-127 1984. 19) Maier, H., Born, I. A., et al.: The effect of chronic ethanol consumption on salivary gland morphology and function in the rat. Alcoholism: Clinical and Experimental Research 10: 425-429 1986. 22) Alappatt, J. L. and Ananthachari, M. D.: A. preliminary study of the structure and function of enlarged parotid glands in chronic relapsing pancreatitis by sialography and biopsy methods. Gut 8: 42-45 1967. 15) Lieber, C. S., Jones, D. P., et al.: Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest 44: 1009-1021 1965. 11) Davidson, D., Leibel, B.S., et al.: Asymptomatic parotid gland enlargement in diabetes mellitus. Ann Intern Med 70: 31-38 1969. 10) Duggan, J. J. and Rothbell, E. N.: Asymptomatic enlargement of the parotid glands. N Engl J Med 257: 1262-1267 1957. 45) Mc Coll, K. E. L., Whiting, B., et al.: Correlation of ethanol concentrations in blood and saliva. Clin Sci 56: 283-286 1979. 8) Du Plessis, D. J.: Parotid enlargement in malnutrition. S Afr Med J 28: 700-703 1956. 49) Traub, O., Drüge, P. M., et al.: Degradation and resynthesis of gap junction protein in plasma membranes of regenerating liver after partial hepatectomy or cholestasis. Proc Natl Acad Sci USA 80: 755-759 1983. 25) Mc Coll, K. E. L., Brodie, M. J., et al. Parotid salivary gland function in patients with exocrine pancreatic insufficiency. Acta Hepato-Gastroenterol 26: 407-412 1979. 39) Ishidate, T., Senoo, A., et al. An electron microscopic study of the pancreas and parotid gland of rats with experimental acute pancreatitis. Tohoku J Exp Med 113: 213-223 1974. 17) Dreiling, D. A., Richman, A., et al.: The role of alcohol in the etiology of acute pancreatitis. The effect of intravenous alcohol on the external secretion of the pancreas. Gastroenterology 20: 636-646 1952. 26) Takeuchi, T., Kameya, T., et al. Development of exocrine cells of the pancreas and parotid gland in rats. Digestion 18: 266-279 1978. 2) Abelson, D. C., Mandel, J. D., et al.: Salivary studies in alcoholic cirrhosis. Oral Surg 41: 188-192 1976. 29) Edmondson, H. A., Bullock, W. K., etal.: Chronic pancreatitis and lithiasis. A clinicopathologic study of 62 cases of chronic pancreatitis. Am J pathol 25: 1227-1247 1949. 12) 平田幸正, 西村ひろみ, 他: 糖尿病における耳下腺腫大とDupuytren拘縮. Diabetes Journal 1: 75-77 1973. |
| References_xml | – reference: 29) Edmondson, H. A., Bullock, W. K., etal.: Chronic pancreatitis and lithiasis. A clinicopathologic study of 62 cases of chronic pancreatitis. Am J pathol 25: 1227-1247 1949. – reference: 46) Rubin, E. and Rottenberg, H.: Ethanolinduced injury and adaptation in biological membranes. Federation Proceedings 41: 2465-2471 1982. – reference: 5) Borsanyi, S. J.: Chronic asymptomatic enlargement of the parotid glands. Ann Otol Rhinol Laryngol 71: 857-867 1962. – reference: 7) Mandel, L. and Baurmash, H.: Parotid enlargement due to alcoholism. JADA 82: 369-373 1971. – reference: 40) Ludwig, H., Schernthaner, G., et al.: Antibodies to pancreatic duct cells in Sjögren's syndrome and rheumatoid arthritis. Gut 18: 311-315 1977. – reference: 10) Duggan, J. J. and Rothbell, E. N.: Asymptomatic enlargement of the parotid glands. N Engl J Med 257: 1262-1267 1957. – reference: 8) Du Plessis, D. J.: Parotid enlargement in malnutrition. S Afr Med J 28: 700-703 1956. – reference: 25) Mc Coll, K. E. L., Brodie, M. J., et al. Parotid salivary gland function in patients with exocrine pancreatic insufficiency. Acta Hepato-Gastroenterol 26: 407-412 1979. – reference: 32) Smith, P. H. and Petel, D. G. Immunochemical studies of the insulin-like material in the parotid gland of rats. diabetes 33: 661-666 1984. – reference: 22) Alappatt, J. L. and Ananthachari, M. D.: A. preliminary study of the structure and function of enlarged parotid glands in chronic relapsing pancreatitis by sialography and biopsy methods. Gut 8: 42-45 1967. – reference: 42) Perec, C. J., Celener, D., et al. Effects of chronic ethanol administration on the autonomic innervation of salivary glands, pancreas and heart. Am J Gastroenterol 72: 46-59 1979. – reference: 43) Baratti, C. M., Rubio, M. C., et al.: Effect of chronic alcohol feeding on adrenergic and cholinergic neurotransmission mechanism. Am J Gastroenterol 73: 21-27 1980. – reference: 41) Kakizaki, G., Sasahara, M., et al. Mechanism of the pancreas-parotid gland interaction. Am J Gastroenterol 70: 635-644 1978. – reference: 16) Rubin, E. and Lieber, C. S. Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates. N Engl J Med 290: 128-135 1974. – reference: 34) Katsuyama, T. and Spicer, S. S.: The surface characteristics of the plasma membrane of the exocrine pancreas. Am JAnat 148: 535-554 1977. – reference: 23) Minaire, Y., Descos, L., et al. Chronic pancreatitis, alcoholic liver cirrhosis and salivary secretion. Digestion 12: 57-60 1975. – reference: 28) Kakizaki, G., Sasahara, M., eta L: Onthe pathogenesis of chronic alcoholic pancreatitis from the viewpoint of experimental results in rats. Int J Pancreatol 2: 101-116 1987. – reference: 15) Lieber, C. S., Jones, D. P., et al.: Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest 44: 1009-1021 1965. – reference: 49) Traub, O., Drüge, P. M., et al.: Degradation and resynthesis of gap junction protein in plasma membranes of regenerating liver after partial hepatectomy or cholestasis. Proc Natl Acad Sci USA 80: 755-759 1983. – reference: 19) Maier, H., Born, I. A., et al.: The effect of chronic ethanol consumption on salivary gland morphology and function in the rat. Alcoholism: Clinical and Experimental Research 10: 425-429 1986. – reference: 24) Grimmel, K., Rossbach, G., et al.: Amylase activity of parotid saliva in acute and chronic pancreatitis. Acta Hepato-Gastroenterol 23: 334-344 1976. – reference: 44) Friedemann, T. E., Motel, W. G., et al.: The excretion of ingested ethyl alcohol in saliva J Lab Clin Med 23: 1007-1013 1938. – reference: 27) 池田浩之, 今野陽三, 他: アルコール依存症における耳下腺病変. 内科56: 163-167 1985. – reference: 9) Katsilambros, L.: Asymptomatic enlargement of the parotid glands. JAMA 178: 513-514 1961. – reference: 1) Borsanyi, S. J. and Blanchard, C.: Asymptomatic enlargement of the parotid gland in alcoholic cirrhosis. South Med J 54: 678-682 1961. – reference: 13) Russotto, S. B. Asymptomatic parotid gland enlargement in diabetes mellitus. Oral Surg 52: 594-598 1981. – reference: 30) Sarles, H., Muratore, R., etal. Aetiology and pathology of chronic pancreatitis. Bib I Gastroenterol 7: 75-120 1965. – reference: 11) Davidson, D., Leibel, B.S., et al.: Asymptomatic parotid gland enlargement in diabetes mellitus. Ann Intern Med 70: 31-38 1969. – reference: 17) Dreiling, D. A., Richman, A., et al.: The role of alcohol in the etiology of acute pancreatitis. The effect of intravenous alcohol on the external secretion of the pancreas. Gastroenterology 20: 636-646 1952. – reference: 45) Mc Coll, K. E. L., Whiting, B., et al.: Correlation of ethanol concentrations in blood and saliva. Clin Sci 56: 283-286 1979. – reference: 33) Sharawy, M., Schuster, G., etal. Association of mitochondria with the plasma mem. brane of the acinar cells of thc mouse submaxillary glands. Actaanat 102: 440-446 1978. – reference: 3) Hemenway, W. G. and Allen, G. W.: Chronic enlargement of the parotid gland: Hypertrophy and fatty infiltration. Laryngoscope 69: 1508-1522 1959. – reference: 39) Ishidate, T., Senoo, A., et al. An electron microscopic study of the pancreas and parotid gland of rats with experimental acute pancreatitis. Tohoku J Exp Med 113: 213-223 1974. – reference: 47) Nakamura, T., Yoshimoto, K., et al.: Reciprocal modulation of growth and differentiated functions of mature rat hepatocytes in primary culture by cell-cell contact and cell membranes. Proc Natl Acad Sci USA 80: 7229-7233 1983. – reference: 4) Kaltreider, H. B. and Talal, N.: Bilateral parotid gland enlargement and hyperlipoproteinemia. JAMA 210: 2067-2070 1969. – reference: 20) Luft, J. H.: Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol 9: 409-414 1961. – reference: 37) Noronha, M., Dreiling, D. A., et al.: The parotid and pancreas. IV Parotid secretion after secretin stimulation as a screening test of pancreatic dysfunction. Am J Gastroenterol 70: 282-285 1978. – reference: 6) Wolfe, S. J., Summerskill, W. H. J., et al.: Parotid swelling, alcoholism and cirrhosis. N Engl J Med 256: 491-495 1957. – reference: 38) Kakizaki, G., Noto, N., et al.: Histologic findings of the parotid gland and bicarbonate content in parotid saliva of dogs with experimentally produced pancreatitis. Tohoku J Exp Med 108: 165-177 1972. – reference: 31) Pinkstaff, C. A.: The cytology of salivary glands. Int Rev Cyto1 63: 141-261 1980. – reference: 36) Cantin, M., Gutkowska, J., et al. Immunocytochemical localization of atrial natriuretic factor in the heart and salivary glands. Histochemistry 80: 80: 113-127 1984. – reference: 26) Takeuchi, T., Kameya, T., et al. Development of exocrine cells of the pancreas and parotid gland in rats. Digestion 18: 266-279 1978. – reference: 35) Schneyer, L., Young, I. A., et al.: Salivary secretion of electrolytes. Physiol Rev 52: 720-777 1972. – reference: 18) Sarles, H., Lebreuil, G., et al.: A comparison of alcoholic pancreatitis in rat and man. Gut 12: 377-388 1971. – reference: 14) Seifert, G.: Zur Pathogenese der Speicheldrüsenschwellung (Sialadenose). Verh Dtsch Ges Pathol 46: 250-256 1962. – reference: 21) 峯川宏一: アルコール性肝障害時における顎下腺の変化. 日大医誌43: 459-473 1984. – reference: 48) Nakamura, T., Nakayama, Y., et al.: Reci-procal modulation of growth and liver functions of mature rat hepatocytes in primary culture by an extract of hepatic plasma membranes. J Biol Chem 259: 8056-8058 1984. – reference: 2) Abelson, D. C., Mandel, J. D., et al.: Salivary studies in alcoholic cirrhosis. Oral Surg 41: 188-192 1976. – reference: 12) 平田幸正, 西村ひろみ, 他: 糖尿病における耳下腺腫大とDupuytren拘縮. Diabetes Journal 1: 75-77 1973. |
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