Assessment of Atrial Fibrillation–Specific Symptoms Before and 2 Years After Atrial Fibrillation Ablation

• Published in: JACC. Clinical electrophysiology Vol. 3; no. 10; pp. 1168 - 1176
• Main Authors: Björkenheim, Anna, Brandes, Axel, Magnuson, Anders, Chemnitz, Alexander, Svedberg, Lena, Edvardsson, Nils, Poçi, Dritan
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2017
• Subjects: atrial fibrillation; catheter ablation; symptoms; symptoms; atrial fibrillation; EHRA; AF; catheter ablation; IQR; ILR
• ISSN: 2405-500X; 2405-5018
• DOI: 10.1016/j.jacep.2017.04.003

The aim of this study was to evaluate patient-reported and physician-assessed atrial fibrillation (AF)–related symptoms after AF ablation. Success of AF ablation is usually defined as freedom from AF, although symptom relief is often patients’ desire. Symptom relief was assessed as perceived by patients using the short, validated, AF-specific symptom questionnaire AF6 and as classified by physicians using the European Heart Rhythm Association (EHRA) classification at baseline and 6, 12, and 24 months after AF ablation. Recurrence of arrhythmia was documented by continuous electrocardiographic monitoring. In total, 54 patients completed the 24-month follow-up. All 6 items on the AF6, AF6 sum score, and EHRA class improved significantly over time. The greatest improvement was seen during the first 6 months after ablation, but AF6 scores showed continued improvement up to 12 months, in contrast to EHRA class. There was a low correlation between AF6 score and EHRA class, but the predictive ability was low. Both AF6 scores and EHRA class were significantly correlated with AF burden at all times after ablation. A change of >9 points in AF6 sum score corresponded to a meaningful reduction in symptom severity. Patient-reported and physician-assessed outcomes were both useful in assessing symptom relief after AF ablation, although patient-reported outcomes were more sensitive tools. There was also a discrepancy between patient-reported and physician-assessed outcomes after ablation. Freedom from AF and a low AF burden most often resulted in a reduction of symptoms, but symptom relief also occurred despite little effect on the arrhythmia. [Display omitted]