The molecular mechanism of ambrosin-induced cytotoxicity of human breast cancer and bladder cancer cells

• Published in: The Journal of biological chemistry Vol. 301; no. 9; p. 110531
• Main Authors: El-Sawy, Layla, Rubin, John R., Broses, Luke, Patsalis, Christopher, Henderson, Marian L., Wilson, Steven J., Glase, Shelly A., Munson, Katherine A., Hiles, Guadalupe Lorenzatti, Cates, Angelica, Emamdjomeh, Amir, Chou, Andrew, Farber, Joseph, Kampf, Jeff W., Magnuson, Brian, Liebert, Monica, Paulsen, Michelle T., Van Golen, Kenneth, Ljungman, Mats, Bankhead, Armand, Palmbos, Phillip L., Day, Kathleen C., Day, Mark L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2025
• Subjects: ambrosin; bladder cancer; breast cancer; cancer stem cells; cancer therapy; glutamine; mitochondrial apoptosis; natural product; STLs; BC; natural product; mitochondrial apoptosis; breast cancer; ambrosin; glutamine; STLs; EGFR; cancer therapy; BrC; bladder cancer; cancer stem cells; TNBC; GSH

Sesquiterpene lactones (STL) are lipophilic compounds synthesized as secondary metabolites in species across the plant kingdom, most notably in the family Asteraceae. One STL, found in North African Ambrosia maritima (A. maritima), and Caribbean Ambrosia hispida (A. hispida), is the compound ambrosi...