CD138-directed adoptive immunotherapy of chimeric antigen receptor (CAR)-modified T cells for multiple myeloma

• Published in: Journal of cellular immunotherapy Vol. 2; no. 1; pp. 28 - 35
• Main Authors: Guo, Bo, Chen, Meixia, Han, Qingwang, Hui, Fan, Dai, Hanren, Zhang, Wenying, Zhang, Yajing, Wang, Yao, Zhu, Hongli, Han, Weidong
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2016
• Subjects: CD138; Chimeric antigen receptor-modified T cells; Multiple myeloma; Chimeric antigen receptor-modified T cells; CD138; Multiple myeloma

Adoptive immunotherapy with T cells expressing a tumor-associated chimeric antigen receptor (CAR) provides a promising approach for tumor therapy. We designed a clinical trial for multiple myeloma (MM) treatment with CAR-modified T cells recognizing CD138 (CART-138). Five patients diagnosed with che...