EFFICIENT APPROACH TOWARDS THE POLYSUBSTITUTED 4H-PYRAN HYBRID QUINOLONE DERIVATIVES AND SUBSEQUENT COPPER-CATALYZED HYDROXYLATION OF HALOARENES
A proficient and feasible approach towards polysubstituted quinolone conjugated 4H-pyrans has been elucidated. The illustrated phenomenon concern with the base-mediated multicomponent reaction and subsequent copper-catalyzed hydroxylation of C-X bond emerging in an amide functionality. The developed...
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Published in | Heterocycles Vol. 102; no. 3; pp. 465 - 479 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
01.01.2021
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Subjects | |
Online Access | Get more information |
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Summary: | A proficient and feasible approach towards polysubstituted quinolone conjugated 4H-pyrans has been elucidated. The illustrated phenomenon concern with the base-mediated multicomponent reaction and subsequent copper-catalyzed hydroxylation of C-X bond emerging in an amide functionality. The developed reaction conditions showcased considerable substrate scope and functional group tolerance by giving the desired products in good yields. |
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ISSN: | 0385-5414 1881-0942 |
DOI: | 10.3987/COM-20-14383 |