GPX4 Downregulation Induces Platelet Ferroptosis in Systemic Lupus Erythematosus

• Published in: Journal of clinical rheumatology and immunology (Online) Vol. 24; no. supp01; p. 42
• Main Authors: Zhou, Zhirui, Yang, Fangyuan, Huang, Ying, Zhuang, Jian, Yuan, Yuxuan, Wei, Jinli, He, Yi
• Format: Journal Article
• Language: English
• Published: World Scientific Publishing Company 2024; World Scientific Publishing

Background: Ferroptosis is a recently discovered type of regulated necrosis and glutathione peroxidase 4 (GPX4) has been recognized as a key enzyme that protects against ferroptosis. However, the role of platelet GPX4 in systemic lupus erythematosus (SLE) has not been explored. In this study, GPX4 l...