Angiotensin-converting Enzyme Gene Insertion／Deletion Polymorphism in Children with Henoch-Schonlein Purpua Nephritis

• Published in: Current medical science Vol. 24; no. 2; pp. 158 - 161
• Main Author: 周建华 田雪飞 徐钦儒
• Format: Journal Article
• Language: English
• Published: China Departmemt of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 2004
• Subjects: Adolescent; Alleles; Child; Child, Preschool; Female; Gene Deletion; Genotype; Humans; IgA Vasculitis - complications; IgA Vasculitis - enzymology; IgA Vasculitis - genetics; Male; Mutagenesis, Insertional; Nephritis - enzymology; Nephritis - etiology; Nephritis - genetics; Peptidyl-Dipeptidase A - genetics; Polymorphism, Genetic; Prognosis; 基因多态性; 病理机制; 血管紧张素转化酶; 过敏性紫癜性肾炎; angiotensin-converting enzyme gene; insertion/deletion polymorphism,Henoch-Schonlein purura nephritis,children
• ISSN: 1672-0733; 2096-5230; 1993-1352; 2523-899X
• DOI: 10.1007/BF02885418

This study investigated the relationship between angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and the occurrence, severity, prognosis of HSPN. The polymorphism of ACE gene in 103 HSPN cases and 100 healthy children was studied by using the poly-merase chain reactions (PCR). Its relation to the clinical manifestation, pathological classification and prognosis of HSPN was analyzed accordingly. The results showed that: (1) there was a significantly higher frequency for DD genotype in HSPN children (P＜0.01) ; (2) DD genotype was more frequently seen in HSPN children with gross hematuria and massive proteinuria (P＜0.05), while DI genotype was more common in HSPN children group with renal insufficiency (P＜0.05); (3)although mesangial proliferative lesion was most frequently observed in 21 biopsied HSPN children,and DD genotype frequency was still higher in children with severe pathology (Class Ⅲ Ⅳ) ; (4)Ⅱ genotype was significantly frequent in HSPN children with complete remission in the follow-up of 32 HSPN children. It was concluded that the deletion allele of ACE gene might play a role, at least to some extent,in the occurrence,deterioration and progression in juvenile HSPN.