Altered expression of specific antioxidant (SOD1 and SOD2) and DNA repair (XRCC1 and OGG1) genes in patients with newly diagnosed type-2 diabetes mellitus

• Published in: Minerva endocrinology Vol. 49; no. 4; p. 398
• Main Authors: Suri, Smriti, Mitra, Prasenjit, Abhilasha, Abhilasha, Saxena, Indu, Garg, M K, Bohra, Gopal K, Sharma, Praveen
• Format: Journal Article
• Language: English
• Published: Italy 23.06.2021
• Subjects: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - genetics; DNA Glycosylases - genetics; DNA Repair - genetics; DNA-Binding Proteins - genetics; Female; Humans; Male; Middle Aged; Superoxide Dismutase - blood; Superoxide Dismutase - genetics; Superoxide Dismutase-1 - genetics; X-ray Repair Cross Complementing Protein 1 - genetics

Uncontrolled increase in reactive oxygen species (ROS) leads to the release of free radicals. Additionally, when antioxidants go below a certain level, major molecules of our system such as DNA, proteins, and many other macromolecules get damaged, leading to cancer, heart diseases, and metabolic syn...