Stimulation of H2O2 production by human peripheral blood neutrophils due to serum or synovial fluid from rheumatoid arthritis patients
To investigate the role of anti-neutrophil cytoplasmic antibodies (ANCA) from patients with rheumatoid arthritis (RA) in neutrophil activation, we examined the effects of serum and synovial fluid (SF) from 10 RA and 9 osteoarthritis (OA) patients and serum from 10 healthy controls on H2O2 production...
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| Published in | Japanese Journal of Clinical Immunology Vol. 17; no. 5; pp. 633 - 637 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
The Japan Society for Clinical Immunology
1994
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0911-4300 1349-7413 |
| DOI | 10.2177/jsci.17.633 |
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| Abstract | To investigate the role of anti-neutrophil cytoplasmic antibodies (ANCA) from patients with rheumatoid arthritis (RA) in neutrophil activation, we examined the effects of serum and synovial fluid (SF) from 10 RA and 9 osteoarthritis (OA) patients and serum from 10 healthy controls on H2O2 production by normal peripheral blood neutrophils (Nt). H2O2 was measured by the flow cytometry method described by Bass et al., 1983. The mean intensity fluorescence (MIF) of Nt with RA serum (mean=13.953, n=10) or SF (18.501, 10) and OA SF (14.017, 8) was significantly higher than that with control serum (9.749, 10). MIF was not correlated with the presence of ANCA. Thus, ANCA in RA had no pivotal role in the stimulation of H2O2 production by Nt. |
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| AbstractList | To investigate the role of anti-neutrophil cytoplasmic antibodies (ANCA) from patients with rheumatoid arthritis (RA) in neutrophil activation, we examined the effects of serum and synovial fluid (SF) from 10 RA and 9 osteoarthritis (OA) patients and serum from 10 healthy controls on H2O2 production by normal peripheral blood neutrophils (Nt). H2O2 was measured by the flow cytometry method described by Bass et al., 1983. The mean intensity fluorescence (MIF) of Nt with RA serum (mean=13.953, n=10) or SF (18.501, 10) and OA SF (14.017, 8) was significantly higher than that with control serum (9.749, 10). MIF was not correlated with the presence of ANCA. Thus, ANCA in RA had no pivotal role in the stimulation of H2O2 production by Nt. |
| Author | Hashimoto, Kozo Nishiya, Koji Ooishi, Naofumi Sasaki, Masahide |
| Author_xml | – sequence: 1 fullname: Ooishi, Naofumi organization: Clinical Laboratory Medicine, Kochi Medical School – sequence: 1 fullname: Hashimoto, Kozo organization: Second Department of Internal Medicine, Kochi Medical School – sequence: 1 fullname: Sasaki, Masahide organization: Clinical Laboratory Medicine, Kochi Medical School – sequence: 1 fullname: Nishiya, Koji organization: Second Department of Internal Medicine, Kochi Medical School |
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| References | 4) Wiik, A.: Delineation of a standard procedure for indirect immunofluorescence detection of ANCA. Acta Pathol. Microbiol. Immunol. Scand., 97 (suppl. 6): 12-13, 1989. 6) Brouwer, E., Huitema, M. G., Klok, P. A. et al.: Antimyeloperoxidase-associated proliferative glomerulonephritis: An animal model. J. Exp. Med., 177: 905-914, 1993. 7) De Clerck, L. S., Struyf, N. J., Bridts, C. H. et al.: Activation of inflammatory cells by immune complexes containing IgE in serum and synovial fluid of patients with rheumatoid arthritis: a study using flow cytometric analysis. Ann. Rheum. Dis., 50: 379-382, 1991. 3) Falk, R. J., Terrell, R. S., Charles, L. A. et al.: Antineutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc. Natl. Acad. Sci. USA, 87: 4115-4119, 1990. 5) Bass, D. A., Parce J. W., DeChatelet L. R. et al.: Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J. Immunol., 130: 1910-1917, 1983. 1) 有村義宏・長沢俊彦:抗好中球細胞質抗体.臨床病理, 41: 866～875, 1993. 2) 西谷皓次・大原栄二・大石尚文・他4名:間接蛍光抗体法による慢性関節リウマチ患者血清中の抗好中球細胞質抗体の検索.臨床病理, 42: 176～182, 1994. |
| References_xml | – reference: 4) Wiik, A.: Delineation of a standard procedure for indirect immunofluorescence detection of ANCA. Acta Pathol. Microbiol. Immunol. Scand., 97 (suppl. 6): 12-13, 1989. – reference: 3) Falk, R. J., Terrell, R. S., Charles, L. A. et al.: Antineutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc. Natl. Acad. Sci. USA, 87: 4115-4119, 1990. – reference: 5) Bass, D. A., Parce J. W., DeChatelet L. R. et al.: Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J. Immunol., 130: 1910-1917, 1983. – reference: 1) 有村義宏・長沢俊彦:抗好中球細胞質抗体.臨床病理, 41: 866～875, 1993. – reference: 7) De Clerck, L. S., Struyf, N. J., Bridts, C. H. et al.: Activation of inflammatory cells by immune complexes containing IgE in serum and synovial fluid of patients with rheumatoid arthritis: a study using flow cytometric analysis. Ann. Rheum. Dis., 50: 379-382, 1991. – reference: 2) 西谷皓次・大原栄二・大石尚文・他4名:間接蛍光抗体法による慢性関節リウマチ患者血清中の抗好中球細胞質抗体の検索.臨床病理, 42: 176～182, 1994. – reference: 6) Brouwer, E., Huitema, M. G., Klok, P. A. et al.: Antimyeloperoxidase-associated proliferative glomerulonephritis: An animal model. J. Exp. Med., 177: 905-914, 1993. |
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| Title | Stimulation of H2O2 production by human peripheral blood neutrophils due to serum or synovial fluid from rheumatoid arthritis patients |
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