The kinetics of focal and circulating inflammatory cytokines in a case (TSLS)
We report a 68-year old woman with streptococcal toxic shock-like syndrome (TSLS), who survived after disarticulation of left arm and was analyzed for the focal and circulating levels of inflammatory cytokines. She was admitted because of narcotizing f asciitis of left forearm and a profound shock....
Saved in:
| Published in | Ensho Saisei Vol. 21; no. 5; pp. 593 - 598 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japanese Society of Inflammation and Regeneration
2001
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1346-8022 1880-5795 |
| DOI | 10.2492/jsir.21.593 |
Cover
| Abstract | We report a 68-year old woman with streptococcal toxic shock-like syndrome (TSLS), who survived after disarticulation of left arm and was analyzed for the focal and circulating levels of inflammatory cytokines. She was admitted because of narcotizing f asciitis of left forearm and a profound shock. We carried out disarticulation because erythematous rash of left arm progressively expanded to the trunk despite antimicrobial chemotherapy. After operation, she rapidly recovered from shock.Streptococcus pyogeneswas isolated from the exudates of the left forearm. We found increased levels of IL-8 and MCP-1 in sera, and also detected increased levels of IL-1β and TNF-α as well as these chamomiles in the exudate of the left forearm before disarticulation. After operation ohe circulating levels of IL-8 and MCP-1 rapidly decreased. A rapid growth of S. pyogenesand released streptococcal pyogenic exotoxin B strongly induce IL-8 and IL-1β production in the left forearm, and a massive release of neutrophil proteases might develop a fluminant fasciitis. |
|---|---|
| AbstractList | We report a 68-year old woman with streptococcal toxic shock-like syndrome (TSLS), who survived after disarticulation of left arm and was analyzed for the focal and circulating levels of inflammatory cytokines. She was admitted because of narcotizing f asciitis of left forearm and a profound shock. We carried out disarticulation because erythematous rash of left arm progressively expanded to the trunk despite antimicrobial chemotherapy. After operation, she rapidly recovered from shock.Streptococcus pyogeneswas isolated from the exudates of the left forearm. We found increased levels of IL-8 and MCP-1 in sera, and also detected increased levels of IL-1β and TNF-α as well as these chamomiles in the exudate of the left forearm before disarticulation. After operation ohe circulating levels of IL-8 and MCP-1 rapidly decreased. A rapid growth of S. pyogenesand released streptococcal pyogenic exotoxin B strongly induce IL-8 and IL-1β production in the left forearm, and a massive release of neutrophil proteases might develop a fluminant fasciitis. |
| Author | Oishi, Kazunori Tomonaga, Takumi Eto, Masao Nagatake, Tsuyoshi Yamaryo, Tsuyoshi Watanabe, Kiwao Senba, Masataka Nakagawa, Kiyoko Amano, Hideaki |
| Author_xml | – sequence: 1 fullname: Yamaryo, Tsuyoshi organization: Department of Internal Medicine, Institute of Tropical Medicine – sequence: 1 fullname: Watanabe, Kiwao organization: Department of Internal Medicine, Institute of Tropical Medicine – sequence: 1 fullname: Eto, Masao organization: Department of Orthopedics, Nagasaki University – sequence: 1 fullname: Amano, Hideaki organization: Department of Internal Medicine, Institute of Tropical Medicine – sequence: 1 fullname: Oishi, Kazunori organization: Department of Internal Medicine, Institute of Tropical Medicine – sequence: 1 fullname: Nakagawa, Kiyoko organization: Department of Internal Medicine, Institute of Tropical Medicine – sequence: 1 fullname: Senba, Masataka organization: Department of Pathology, Institute of Tropical Medicine – sequence: 1 fullname: Nagatake, Tsuyoshi organization: Department of Internal Medicine, Institute of Tropical Medicine – sequence: 1 fullname: Tomonaga, Takumi organization: Department of Orthopedics, Nagasaki University |
| BookMark | eNo9kE1PAjEQhhuDiYic_AM9asxiP5fu0SB-JBgP4LmZdlsoLl3Trgf-vQsYLjOTmed9k3mv0SC20SF0S8mEiYo9bnNIE0YnsuIXaEiVIoWcVnLQz1yUhSKMXaFxzsEQQtSUUVoO0cdq4_B3iK4LNuPWY99aaDDEGtuQ7G8DXYhrHKJvYLeDrk17bPdde5Dkfo0BW8gO362Wi-X9Dbr00GQ3_u8j9PUyX83eisXn6_vsaVFYWlFecAAPHJi0U0ZqpZgqhaFM8FJWBhyraOmV4xUx0jEpnABpvCK1MMTWxnE-Qg8nX5vanJPz-ieFHaS9pkQfwtCHMDSjug-jp59P9DZ3sHZnFlL_dOOOLCOEHvlT6WXns91A0i7yP5dgbD8 |
| ContentType | Journal Article |
| Copyright | The Japanese Society of Inflammation and Regeneration |
| Copyright_xml | – notice: The Japanese Society of Inflammation and Regeneration |
| DBID | AAYXX CITATION |
| DOI | 10.2492/jsir.21.593 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1880-5795 |
| EndPage | 598 |
| ExternalDocumentID | 10_2492_jsir_21_593 article_jsir2001_21_5_21_5_593_article_char_en |
| GroupedDBID | 5GY AAFWJ ALMA_UNASSIGNED_HOLDINGS AMTXH CS3 JSF KQ8 OK1 RJT AAYXX BAPOH CITATION |
| ID | FETCH-LOGICAL-c1913-3aafa3a25c720d882864b1243659bae2916f8e390b5e254e4a5bf80d4b0cdbe33 |
| ISSN | 1346-8022 |
| IngestDate | Tue Jul 01 00:34:36 EDT 2025 Wed Sep 03 06:30:07 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 5 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c1913-3aafa3a25c720d882864b1243659bae2916f8e390b5e254e4a5bf80d4b0cdbe33 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jsir2001/21/5/21_5_593/_article/-char/en |
| PageCount | 6 |
| ParticipantIDs | crossref_primary_10_2492_jsir_21_593 jstage_primary_article_jsir2001_21_5_21_5_593_article_char_en |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2001 |
| PublicationDateYYYYMMDD | 2001-01-01 |
| PublicationDate_xml | – year: 2001 text: 2001 |
| PublicationDecade | 2000 |
| PublicationTitle | Ensho Saisei |
| PublicationTitleAlternate | Inflammation and Regeneration |
| PublicationYear | 2001 |
| Publisher | The Japanese Society of Inflammation and Regeneration |
| Publisher_xml | – name: The Japanese Society of Inflammation and Regeneration |
| References | 2) Vivec K, Majesky MW, Ling-Ling Li, Black RA, Musser JM : Cleavage of interleukin 1 R (IL-1 β) precursor to produce active IL-1 β by a conserved extracellular cysteine protease from Streptococcus pyogenes. Proc Natl Acad Sci USA 90 : 7676-7680, 1993. 4) Hack CE, Hart M, van Schijndel RJMS, Eerenberg AJM, Nuijens JH, Thijs LG, Aarden LA : Interleukin-8 in sepsis : Relation to shock and inflammatory mediators. 60 : 2835-2842, 1992. 1) The Working Group on Severe Streptococcal Infections : Defining the group A streptococcal toxic shock syndrome. JAMA 269 : 390-391, 1993. 4) Standiford TJ, Arenberg DA, Danforth JM, Kunkel SL, VanOtteren GM, Strieter RM : Lipoteicoic acid induces secretiion of ineerleukin-8 from human blood manocytes : a cellular and molecular analysis. Infect Immun 62 : 119-125, 1994. 12) Stevens DL, Bryant AE, Hackett SP, Cahng A, Peer G, Kosanke S, Emerson T, Hinshow L : Group A streptococcal bacteremia : the role of tumor necrosis factor in shock and organ failure. J Infect Dis 173 : 619-626, 1996. 10) Miller EJ, Cohen AB, Matthay MA : Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med 24 1448-1454, 1996. 9) Muller-Alouf H, Alouf J, Gerlach D, Ozegowski J-H, Fitting C : Comparative study of cytokine release by human peripheral blood mononuclear cells stimulated with Streptococcus pyogenes super-antigenic erythrogenic toxins, heat killed Streptococci, and lipopolysaccharide. Infect Immun 62 : 4915-4921, 1994. 11) Bossik AWJ, Paemen L, Jansen PM : Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. Blood 86: 3841-3847, 1995. 3) 赤池孝章, 岡本竜哉: A群レンサ球菌の毒素と病原性. 劇症A群レンサ球菌感染症. 渡辺治雄, 清水可方編. 近代出版, 東京, 1997, p149-158. 13) Matsushima K, Oppenheim JJ, Interleukin-8. MCAF : novel inducible inflammatory cytokines inducible by IL-1 and TNF. Cytokine 1: 2-13, 1989. 6) Oishi K, Sonoda F, Kobayashi S, Iwagaki A, Nagatake T, Matsushima K, Matsumoto K : Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases. Infect Immun 62 : 4145-4152, 1994. 5) Chollet-Martin S, Montravers P, Gilbert C, Desmonys JM, Fagon JY, Gougerot-Pocidalo MA : High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. Infect Immun 61: 4553-4559, 1993. 8) Soto A, Evans TJ, Cohen J : Proinflammatory cytokine production by human peripheral blood mononuclear cells stimulated with cell free supernatants of viridans streptococci. Cytokine 8 : 300-304, 1996. |
| References_xml | – reference: 10) Miller EJ, Cohen AB, Matthay MA : Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med 24 1448-1454, 1996. – reference: 1) The Working Group on Severe Streptococcal Infections : Defining the group A streptococcal toxic shock syndrome. JAMA 269 : 390-391, 1993. – reference: 11) Bossik AWJ, Paemen L, Jansen PM : Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. Blood 86: 3841-3847, 1995. – reference: 12) Stevens DL, Bryant AE, Hackett SP, Cahng A, Peer G, Kosanke S, Emerson T, Hinshow L : Group A streptococcal bacteremia : the role of tumor necrosis factor in shock and organ failure. J Infect Dis 173 : 619-626, 1996. – reference: 13) Matsushima K, Oppenheim JJ, Interleukin-8. MCAF : novel inducible inflammatory cytokines inducible by IL-1 and TNF. Cytokine 1: 2-13, 1989. – reference: 4) Hack CE, Hart M, van Schijndel RJMS, Eerenberg AJM, Nuijens JH, Thijs LG, Aarden LA : Interleukin-8 in sepsis : Relation to shock and inflammatory mediators. 60 : 2835-2842, 1992. – reference: 3) 赤池孝章, 岡本竜哉: A群レンサ球菌の毒素と病原性. 劇症A群レンサ球菌感染症. 渡辺治雄, 清水可方編. 近代出版, 東京, 1997, p149-158. – reference: 6) Oishi K, Sonoda F, Kobayashi S, Iwagaki A, Nagatake T, Matsushima K, Matsumoto K : Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases. Infect Immun 62 : 4145-4152, 1994. – reference: 8) Soto A, Evans TJ, Cohen J : Proinflammatory cytokine production by human peripheral blood mononuclear cells stimulated with cell free supernatants of viridans streptococci. Cytokine 8 : 300-304, 1996. – reference: 9) Muller-Alouf H, Alouf J, Gerlach D, Ozegowski J-H, Fitting C : Comparative study of cytokine release by human peripheral blood mononuclear cells stimulated with Streptococcus pyogenes super-antigenic erythrogenic toxins, heat killed Streptococci, and lipopolysaccharide. Infect Immun 62 : 4915-4921, 1994. – reference: 4) Standiford TJ, Arenberg DA, Danforth JM, Kunkel SL, VanOtteren GM, Strieter RM : Lipoteicoic acid induces secretiion of ineerleukin-8 from human blood manocytes : a cellular and molecular analysis. Infect Immun 62 : 119-125, 1994. – reference: 5) Chollet-Martin S, Montravers P, Gilbert C, Desmonys JM, Fagon JY, Gougerot-Pocidalo MA : High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. Infect Immun 61: 4553-4559, 1993. – reference: 2) Vivec K, Majesky MW, Ling-Ling Li, Black RA, Musser JM : Cleavage of interleukin 1 R (IL-1 β) precursor to produce active IL-1 β by a conserved extracellular cysteine protease from Streptococcus pyogenes. Proc Natl Acad Sci USA 90 : 7676-7680, 1993. |
| SSID | ssib000872116 ssib029852164 ssib002822089 ssj0056297 ssib053390299 ssib005901891 ssib022574980 |
| Score | 1.286586 |
| Snippet | We report a 68-year old woman with streptococcal toxic shock-like syndrome (TSLS), who survived after disarticulation of left arm and was analyzed for the... |
| SourceID | crossref jstage |
| SourceType | Index Database Publisher |
| StartPage | 593 |
| SubjectTerms | inflammatory cytokine interleukin (IL) -8 neutrophils storeptococcal exotoxin (SPE) B streptococcal toxic shock-like syndrome (TSLS) |
| Title | The kinetics of focal and circulating inflammatory cytokines in a case (TSLS) |
| URI | https://www.jstage.jst.go.jp/article/jsir2001/21/5/21_5_593/_article/-char/en |
| Volume | 21 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Ensho Saisei, 2001/09/28, Vol.21(5), pp.593-598 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9swFBdZN8YuY5-s-0KHHjaKM9uSYvuwQxkbYSODsRR6M5IsrV6oXZKYkf71e0-yhVN66AZBBFnPTvx-fvpJfh-EHFlm4ypJWMRnqYl4UWVRMdN5pPJYVVmRy1xjNPLi-2x-yr-eibPJ5HLktdRt1VRf3RhX8j9ahT7QK0bJ_oNmw0mhA76DfqEFDUN7ax2vgCa6VMvA-mw7hP7req1dYS4XsWJB7Rf-dbrebVsUcW6w8ljDJIYkc_kTffiKvX36ZnPedqiCDb5eqsO2sVzJX_KPDyWrd-2qDRu1uJ_lXTSuuqZdB5GTC-kqfB_P68oAZQ2mRmLgnDuy3HS7FsT3diGSkclkHFMa--jiqfF9YBUikfnymYOdTZMRnsTIaApfI7Gff4WvSn3dtGNmQzTtm3o9TZNpkBkn0L42sQV3Q1jooHiJwmWalCB8h9xNsyxBJ9BvP4IFAu5bxCku0PxcDuTQl-cZ_qOP8MSTfRj9kj1Oc-830PrBJdCxlOUj8rBfXtATj5XHZGKaJ-T-onegeEoWABk6QIa2ljrIUIAMHUGGjiFDA2Sgm0qKkKHvEDDvn5HTL5-Xn-ZRX1Ej0rAuZxGT0komU6GzNK5yTCHAFTA8NhOFkiaFtYLNDdwDJUwquOFSKJvHFVexrpRh7Dk5aNrGvCA0hydZCWZVViRcFbrIjWCVVEaqKrFcH5Kj4Z6Ulz5xSnmDHg7JR3-_wqD-aXKDEGluoG9gfDiMQYlgA17e7jKvyAPvPIif1-Rgu-7MG2CTW_XWAeAvlLp2ng |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+kinetics+of+focal+and+circulating+inflammatory+cytokines+in+a+case+%28TSLS%29&rft.jtitle=Enshou%2C+saisei&rft.au=Nakagawa%2C+Kiyoko&rft.au=Oishi%2C+Kazunori&rft.au=Amano%2C+Hideaki&rft.au=Yamaryo%2C+Tsuyoshi&rft.date=2001&rft.issn=1346-8022&rft.eissn=1880-5795&rft.volume=21&rft.issue=5&rft.spage=593&rft.epage=598&rft_id=info:doi/10.2492%2Fjsir.21.593&rft.externalDBID=n%2Fa&rft.externalDocID=10_2492_jsir_21_593 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1346-8022&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1346-8022&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1346-8022&client=summon |