A proposed clinical tool to identify high-risk patients for monogenic lupus: a pilot study

• Published in: Clinical and experimental rheumatology Vol. 43; no. 3; p. 538
• Main Authors: Al-Mayouf, Sulaiman M, Hadef, Djohra, Aljaberi, Najla, Movahedi, Nasim, AlEed, Ashwaq, Almutairi, Abdulaziz, Asiri, Abdulrahman, Volpi, Stefano, Gattorno, Marco, Wu, Chao-Yi, Tamim, Hani, Al-Saleem, Alhanouf
• Format: Journal Article
• Language: English
• Published: Italy 01.03.2025
• Subjects: Adolescent; Age of Onset; Antibodies, Antinuclear - blood; Case-Control Studies; Child; Child, Preschool; Decision Support Techniques; Female; Genetic Predisposition to Disease; Genetic Testing; Humans; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Male; Phenotype; Pilot Projects; Predictive Value of Tests; Risk Assessment; Risk Factors; ROC Curve
• ISSN: 0392-856X
• DOI: 10.55563/clinexprheumatol/tjt58t

To develop an easy-to-use and efficient clinical score to identify monogenic lupus based on clinical presentations and to stratify patients who may benefit from confirmatory molecular genetic testing. A comprehensive literature review identified 55 distinct items across 12 clinical and laboratory do...